Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Marine Natural Products"”.
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Marine natural products as antimicrobial chemical defenses and sources of potential drugs
Marine organisms are widely recognized sources of an impressive array of structurally unusual compounds. Marine natural products have exhibited interesting biomedical activities, provided targets for synthetic organic chemists, and afforded opportunities for elucidation of enzymatic mechanisms …
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Marine Natural Products Chemistry of a Caribbean Tunicate and a Palau Sponge
Finally, new bromotyrosine-derived metabolites of the spirocyclohexadiene-isoxazoline class, named subereamides, have been isolated from the Palau sponge Suberea laboutei along with known psammaplysins A, B and D, and ceratinamide B. In addition, a new cytotoxic dibromotyramine derivative, …
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The Synthesis-Enabled Stereochemical Elucidation of the Marine Natural Products Hemicalide and Phormidolide A
… structural complexity and biological activity of marine natural products have made them attractive targets for synthetic chemists. In cases where their relative and/or absolute configuration is unknown, total synthesis becomes a powerful method to enable their structural elucidation, as …
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Characterization of Neuromodulatory and Neurotoxic Marine Natural Products Using Microseparations, NMR and Mass Spectrometry
… of different neuromodulatory compounds from marine species are examined including toxins from venomous cone snails. Conotoxins represent a wealth of neuropharmacologically active peptides as well as tools for basic research and a review of cone snails and their toxins is included.
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Structure Elucidation and Biosynthesis of Selected Bioactive Marine Natural Products (Bromophenols, Aplysina, Fistularis, Kelletia)
The biosynthesis of bromophenols in Aplysina fistularis has been reinvestigated, making use of liposome-encapsulated precursors. The incorporation of both phenylalanine and tyrosine into two antimicrobial sponge metabolites, 2,6-dibromo-4-hydroxy-2,5-cyclohexadienone-4-acetamide and …
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Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tuberculosis and malaria
… and/or cure diseases. A greater number of these natural products have not progressed to the latter stages of development as drugs largely due to the drawbacks of toxicity, limited supply, growing concerns to conserve terrestrial and marine ecosystems and their biodiversity, which impedes sample …
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Synthesis of Dimeric Pyrrole-Imidazole Alkaloids
… as oroidin family of alkaloids, are a class of marine natural products with unique structural diversity and complexity. Focusing on the synthesis of the higher order dimeric pyrrole-imidazole alkaloids, my graduate work comprises two components: a synthetic study of massadine and the total …
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Untersuchungen auf Sekundärstoffproduktion und physiologische Charakterisierung von marinen heterotrophen Bakterien aus dem deutschen Wattenmeer
Within the investigation of novel marine natural products from previously uncultered bacteria, over 90 isolates from the german Wadden Sea were screened for their potential for secondary metabolite production. 16 S rRNA gene analysis revealed, that 56 strains affiliated with Gram positive bacteria …
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Continued Progress Towards Efficient Syntheses Of Cephalostatin North 1 Analogs
… ritterazines represent an intriguing class of marine natural products in both structure and biological activity, and the progress towards the synthesis of high valued analogs with a focus on process orientated methodology is described herein. Included in the pages to follow, is the further …
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Synthesis of Novel Chiral Heterocyclic Compounds for Antibacterial Agents and Peptidomimetics
… are the Aeruginosins. They are a family of marine natural products isolated from a blue-green algae, which display inhibitory activity against serine proteases such as thrombin, trypsin, and factor VIIa. Most aeruginosins contain an heterocyclic moiety called the …
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Synthesis and biological evaluation of aeruginosin based compounds and self-assembly of glucosamine based compounds
<p>Aeruginosins are a family of marine natural products containing mostly non-proteogenic amino acids. These compounds contain a common 2-carboxy-6-hydroxy-octaindole (Choi) rigid bicyclic structure. Many aeruginosins are inhibitors for enzymes involved in the blood coagulation cascade, such as …
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Mangrolide A, A Novel Marine Derived Polyketide with Selective Antibiotic Activity
… and new techniques and sources are required. The marine environment contains novel natural product-producing bacteria and has yielded new compounds with potent activity. This dissertation represents work towards new antibiotic discovery from marine natural products. Chapter 1 provides an …
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Strategies for the synthesis of bioactive compounds: biomimetic approaches to the Salinosporamides and the hexadehydro-Diels-Alder reaction
… are a subset of polyketide-derived marine natural products that have as their key structural feature a fused γ-lactam/β-lactone moiety. These molecules are known to inhibit the 20S proteasome (20SP) by utilizing the β-lactone reactivity, a promising target for cancer therapeutics. We …
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Development and Application of a Novel Assay for Rapid Identification of Cellular Prion Protein Modulators
… screening (HCS) to identify small molecules, natural compounds, and genetic modulators capable of downregulating PrPC levels. A broad range of chemical libraries, including FDA/EMA-approved drugs and computationally selected candidates, were screened, leading to the identification of promising …
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Designed analogues of the aplyronines for use in antibody-drug conjugates
… aplyronines are a family of structurally complex marine macrolides, isolated from the sea hare Aplysia kurodai, that exhibit picomolar growth inhibitory activity in the NCI 60 cell line panel. An unprecedented heterotrimeric complex has been observed to form between aplyronine A and actin and …
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Towards the Structural Elucidation and Total Synthesis of Hemicalide: Assignment of the C29-C46 Region
Marine natural products are a known source of novel bioactive compounds. However, in many cases, low isolation yields and lack of full structural information necessitate total synthesis to achieve their structural elucidation, and produce sufficient material for biological studies. This thesis …
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Functional Studies of Novel Bioactives From Complex Host-Microbiomes as Drug Leads for Cancer, Infectious Disease, Depression and Pain
… This evolution has helped diminish the stigma of natural products and compound supply issues. The issue of compound supply has also been addressed to some extent with the emergence of recombinant technologies and new synthetic methodology. With approximately 60 years of research performed after …
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Anticancer and antibiotic leads from marine organis
During the past three decades, the development of marine natural products as drug leads has become a promising avenue for research. As our efforts towards the discovery of anticancer and antibiotic drug leads from marine organisms, modifications of anticancer drug candidate kahalalide F, isolations …
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Synthesis and Evaluation of Naturally Occuring Halogenated Bipyrroles in a Relevant Marine Species, Fundulus Heteroclitus
… be biogenic in nature, derived from evidence of marine natural products that are persistent in the environment and widespread in the Pacific and Atlantic Ocean. The HDBPs exhibit chlorinated and brominated substitution patterns that closely resemble anthropogenic pollutants like the …
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Rationally designed aplyronine analogues for use in antibody-drug conjugates
The aplyronines are a family of antimitotic marine macrolides which show highly potent antiproliferative effects at picomolar concentrations in human cancer cell lines. Through a novel dual protein-targeting mechanism of action, their exquisite potency renders the aplyronines promising drug …
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