Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Marginal zone B cells"”.
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Alternations in the Splenic Marginal Zone with Age
<p>Splenic marginal zones are architecturally organized to generate a rapid response against blood- borne antigens entering the spleen. The marginal zone is a distinct anatomical micro-environment whose main components include the marginal zone macrophages, the marginal zone B cells, the marginal …
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Functional analysis of KLF2 and its lymphoma-derived mutants
Splenic marginal zone lymphoma is a low-grade B cell neoplasm, which originates from the splenic marginal zone B cells. Whole exome studies show recurrent somatic mutations in KLF2, and genes in the NOTCH2, NF-κB, BCR and TLR signalling pathways – pathways that are essential for the development and …
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Role of Notch Signaling and GATA-3 in Establishing T-lineage Commitment and Survival in Developing Thymocytes
… immune response, including antigen-specific T cells, is crucial in resolving infections and protecting against tumourigenesis. However, the precise molecular signals needed for the development of these cells are still not clearly defined. The Notch signaling pathway is required to commit …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
Large numbers of blood cells need to be continuously replaced in order to sustain the crucial functions of the immune system, oxygen transport and blood clotting. The large diversity of cell types required to maintain the integrity of the blood system are all produced from blood forming or …
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The role of antibodies in tuberculosis
… Fourthly, I tested whether unswitched memory B cells, and specifically the marginal zone B cells (MZB) subset, are impacted by ATB. MZB respond to capsular pathogens and could thus recognize the M.tb cell wall. MZB are found to be depleted in ATB but are not enriched at the site of disease in …
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Early Growth Response Protein 2 (EGR2) regulation of B cell differentiation in lupus-prone mice
… treatment. It involves abnormal activation of B cells, which produce pathogenic autoantibodies that contribute to inflammation and tissue damage in multiple organs. Therapeutic depletion of B cells in human lupus patients had mixed success due to the complex heterogeneity of B cell subsets, …
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The modulation of autoimmune disease progression in mouse models
B cells play crucial roles in the development of the two human autoimmune diseases, type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). In the past decade, numerous studies showed positive responses of B cell depletion therapies in these two diseases. However, the beneficial effects are …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte subsets in splenocytes and in peripheral blood. Genetic mapping and sequencing identified the two mutations. The first was a …
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The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice
… chabaudi AS (P. chabaudi) infected red blood cells with appropriate controls. The mice were euthanased at 7, 10, 17, 26 days after malaria infection for multiparameter flow cytometry analysis. We compared P. berghei and P. chabaudi, their effects on B cells, effector and memory T cells and the …