Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Mapk activation"”.
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Age differentiation of rat smooth muscle cells : altered proliferation profile, cellular changes, and implications for atherosclerotic plaque destabilization
… FGF receptor production and expression, and MAPK production and activation. We found that the overall cellular production of receptor and MAPK in smooth muscle cells remains unaffected by aging. However, the proliferation response of aged smooth muscle cells was muted in response to …
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Development of a novel co-culture based in vitro model system to study the wound healing process
… marker. Treatment with 1 mM OTC reduced activation of ERK1/2 and p38 mitogen-activated protein kinases (MAPK) at 21 days post-surgery suggesting potential anti-scarring mechanism. However, large animal to animal variation in the expression levels of collagen biosynthesis markers made it …
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FUNCTIONAL ANALYSIS OF ANAPLASTIC LYMPHOMA KINASE DURING EMBRYONIC NEUROGENESIS IN ZEBRAFISH
… discovered as an oncogene. ALK kinase over-activation has been associated with human cancers, most importantly neuroblastoma. However, little is known about ALK¿s endogenous function in development. I identified an alk ortholog in zebrafish and used this model species to analyze the …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… its phosphorylation at S62 and T58 residues via activation of Erk1/2 and inhibition of PI3K/Akt along with subsequent activation of GSK-3β in response to low dose ATRA treatment. HL-60 cells treated with GSK-3β or proteosome inhibitors revealed marked accumulation of c-Myc both in the presence …
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DUSP5 Regulation of Inflammation and Insulin Signaling
… signaling of mitogen-activated protein kinases (MAPKs) within adipocytes (i.e. fat cells) and muscle cells that drive systemic inflammation and insulin resistance, leading to T2D. Until recently, most studies focused on the role of upstream kinases that link TNF? to MAPK activation (i.e. …
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Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia
… arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke. The more specific goals have been the …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… EGFR dimerization to stimulate downstream MAPK activation. We also investigated the consequences of PCDH7 loss of function in EGFR mutant human cells and mouse models. Knockout of PCDH7 sensitizes EGFR mutant cell lines to tyrosine kinase inhibitors (TKIs), the current method of treatment …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… EGFR dimerization to stimulate downstream MAPK activation. We also investigated the consequences of PCDH7 loss of function in EGFR mutant human cells and mouse models. Knockout of PCDH7 sensitizes EGFR mutant cell lines to tyrosine kinase inhibitors (TKIs), the current method of treatment …
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Identification of an extracellular adenosine 5'-triphosphate receptor in Arabidopsis thaliana
… do not show an ATP-induced calcium response, MAPK activation, or altered gene expression. Wounding of the plant can release up to 40 æM ATP in the wound site. Consistent with this, ectopic expression of DORN1 increased the plant response to physical wounding. We propose that DORN1 is essential …
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The impact of diabetes on cardiac remodelling after myocardial infarction: potential role of thyroid hormone signalling
… kinase hypertrophic signalling p38 MAPK. In contrast, ERK, p-ERK and p-p38 MAPK levels were not changed in DM+AMI as compared to non-infarcted hearts (DM+SHAM). TH administration after AMI prevented hypothyroidism and resulted in decreased β-MHC expression, increased wall thickening …
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Assessing eIF4E-S209 Signaling and Translationally Regulated Mechanisms in Neurodegeneration
… implicated mitogen activated protein kinase (MAPK) signaling cascades. The MAPKs extracellular signal-regulated kinase (ERK) and p38 can play an important role in translational control through the mRNA cap binding protein, eukaryotic translation initiation factor 4E (eIF4E). Downstream of …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… ATM to sCLU expression mediated by IGF-1/IGF-1R/MAPK activation was uncovered. IGF-1 ligand promoter activity, mRNA, and protein expression induced after exposure to ionizing radiation (IR), hydrogen peroxide, or topoisomerase I and II-alpha poisons matched sCLU expression. Elevated basal …
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STRUCTURE-FUNCTION STUDIES OF TRANSLOCATED EFFECTORS FROM THE LATE BLIGHT PATHOGEN
… four PexRD2-interacting host proteins, including MAPKKKε, a known positive regulator of plant immunity. MAP-kinase cascades transduce the perception of invading pathogens into effective defence responses, and MAPKKKε is involved in resistance against P. infestans. PexRD2 specifically suppresses …
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Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
… signaling cascade downstream of Dectin-2 activation in macrophages and to understand their importance in mediating the immune response to <em>C.</em> <em>albicans in vivo</em>. Using macrophages derived from Phospholipase-C-gamma 1 and 2 (PLCγ1and PLCγ2) knockout mice, we demonstrate that …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… the extent of intracellular signaling (MAPK activation) relative to sources of Fgf expression, and the transcriptional responses of cells to Fgf signaling during embryogenesis. By a macroarray analysis, I identified putative transcriptional targets of Fgf signaling in late gastrulation, …
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Characterisation of Anti-Apoptotic Signalling Pathways in Hepatocytes activated by alpha-Lipoic Acid and Atrial Natriuretic Peptide
… properties. In fact, the LA-mediated activation of the PI3-K/Akt survival pathway seemed to be responsible for the antiapoptotic properties of alpha-lipoic acid. Consequently, incubation with a specific PI3-K-inhibitor significantly reduced both, R-LA-mediated decrease in caspase …
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Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues
… was shown to inhibit TPA-induced AP-1 transactivation. Inhibition of AP-1 transactivation suggests the involvement of mitogen-activated protein kinase (MAPK) signaling pathways which are upstream effectors of AP-1 transactivation, and so the involvement of MAPKs was assessed in this study. …
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The Role of the Mitogen Activated Protein Kinase Pathway in Cisplatin and Noise-Induced Hearing Loss
… loss and the mitogen activated protein kinase (MAPK) pathway is one. The MAPK pathway consists of a phosphorylation cascade with RAF, MEK1/2, ERK1/2 as the main three kinases that effect a multitude of cellular processes. The MAPK pathway has been associated with hearing loss; however, its exact …
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Postembryonic Development and Adult Plasticity of the Mushroom Bodies in the Honey Bee Brain
… binding and dimerization regions. Vertebrate p38 MAPK activation sites are conserved in honey bee MEF2, indicating that insect MEF2 proteins are also regulated by p38 MAPK MAPKs have been shown to be involved in vertebrate learning and memory. Finally, Golgi analysis of the dendritic arbors of …
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