Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Map3k1"”.
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Identification and Characterisation of New Mouse Models for Hearing Loss
… mutation in the mitogen-activated protein kinase Map3k1 gene. In addition to an eyes-open-at-birth phenotype, Map3k1goya/goya mice initially develop supernumerary cochlear outer hair cells (OHCs) that subsequently degenerate, and a progressive profound hearing loss is observed by 9-weeks of age. …
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Protein-Protein Interactions in Cell Cycle Proteins: An <i>In silico</i> Investigation of Two Important Players
… protein kinase kinase kinase 1 (MAP3K1) and (2) Heat Shock Factor Binding Protein 1 (HSPB1). Our findings place both NEK10 – MAP3K1 and NEK10 – HSPB1 interactions in the context of ciliogenesis and provide valuable insights into the underlying mechanism and functional significance …
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Rare Genetic Variants and Cancer Susceptibility
… ATM, BRCA1, BRCA2, CHEK2 and PALB2 together with MAP3K1. Associations at P<1x10-4 were additionally identified for LZTR1, ATRIP and BARD1. For deleterious rare missense variants or protein-truncating variants, we additionally identified an association for CDKN2A at exome-wide significance. The …
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Identification and Characterization of Novel Kinases that Regulate BRCA1 Expression and Function
Transcriptional and functional regulation of the breast cancer susceptibility gene 1 (BRCA1) in the pathogenesis of sporadic breast cancers is poorly understood. We developed a functional assay, which assesses the ability of BRCA1 to localize to sites of DNA damage and form ionizing …