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Showing 1 to 20 of 166 for “"Map Kinase"”.

  1. The Regulation of Oncogenic MAP Kinase Signalling by Dual-Specificity MAP Kinase Phosphatases

    Kidger, Andrew M.University of Dundee2016

    … observed in human cancers. Dual-specificity MAP kinase phosphatases (DUSPs or MKPs) are important negative regulators of this pathway and could therefore play an important role in modulating the oncogenic potential of signalling. DUSP5 and DUSP6/MKP-3 are ERK-specific MKPs, which are …

    dundee Repository record

  2. Substrate Interaction and Sub-Cellular Localization in Map Kinase Pathways

    Ranganathan, Aarati2010

    Protein kinase cascades control responses to extracellular cues by transmitting signals throughout the cell. Prominent among multifunctional enzymes in kinase cascades are the mitogen-activated protein kinases (MAPKs). Among the various MAPKs identified, the extracellular signal-regulated kinases, …

    utswmed Repository record

  3. MAP kinase phosphatase-2 in vascular smooth cell muscle function

    Torrance, EmmaUniversity of Strathclyde2013

    … occurs involves ligand-induced activation of MAP kinase signalling (Schad et al., 2011). MAP kinases have been noteworthy but troublesome targets in cardiovascular therapeutics; thus exploration of targeting endogenous regulatory dual specificity proteins namely MAP kinase phosphatases has …

    strathclyde Repository record

  4. HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.

    Henry, Jason L.2002

    … TNFα). Cell lysate fractions were analyzed for MAP Kinase activity and NFκB activation, and culture supernatants were assayed for inflammatory cytokines (IL-6 and IL-8). The production of IL-6 and IL-8 was significantly enhanced by tat but not by gp120. Both gp120 and tat, however, induced …

    etsu Repository record

  5. The Role of Polarity Proteins in Regulating MAP Kinase Pathways in Saccharomyces cerevisiae

    Basu, SukanyaState University of New York at Buffalo2019

    Ph.D.

    buffalo Repository record

  6. The Oncogenic Map Kinase Signaling Pathway Modulates Mhc-I Surface Expression In Melanoma

    Bradley, Sherille Denae2014

    <p>The mitogen-activated protein kinase (MAPK) pathway is a cascade of serine-threonine kinases involved in cell growth, proliferation, and apoptosis; it is one of the most well-known pathways associated with melanoma progression. The MAPK pathway is constitutively activated in melanomas due to …

    uthsc Repository record

  7. Analysis of the regulation mechanism of LmxMPK1, a Leishmania mexicana MAP kinase homologue

    McAleer, Patrick PearseUniversity of Strathclyde2012

    … new treatment regimens. LmxMPK1 is an essential MAP kinase homologue in Leishmania mexicana.;Previous work had suggested that it might be regulated in a novel manner that differed from that of MAP kinases in higher eukaryotes. This study found evidence to support this theory, although a …

    strathclyde Repository record

  8. Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity

    Haagenson, Kelly2013

    … </p> <p> <strong>EXPRESSION AND REGULATION OF MAP KINASE PHOSPHATASES 1 and 2 IN BREAST CANCER TAMOXIFEN SENSITIVITY</strong> </p> <p>by</p> <p> <strong>KELLY K. HAAGENSON</strong> </p> <p> <strong>May 2013</strong> </p> <p> <strong>Advisor:</strong> Dr. Malathy Shekhar</p> <p> …

    wayne-thes Repository record

  9. REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5

    TANG PENG2014

    … INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES IN OBESITY-RELATED METABOLIC DISEASES. WE FOUND THAT IRF3 IS A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE DEVELOPMENT OF OBESITY AND TYPE 2 DIABETES. MICE …

    nus Repository record

  10. MAP kinaseカスケードにおける分子間相互作用の解析

    田ノ上, 拓自京都大学 (Kyoto University)2001

    本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである

    kyoto Repository record

  11. Investigating the role of a JNK-like MAP kinase signaling in regulating dauer developmental arrest in Caenorhabditis elegans

    Dogra, DeepshikhaMassachusetts Institute of Technology2021

    … the role of a stress-activated c-Jun Nterminal Kinase (JNK)-like mitogen activated protein kinase (MAPK), KGB-1, in dauer formation. In view of established roles of JNK MAPK in stress-activated signal transduction, the identification of the KGB-1 pathway in regulating dauer diapause is …

    mit Repository record

  12. The Roles of a Conserved MAP Kinase Pathway in the Regulation of Development and Secondary Metabolism in Aspergillus Species

    Frawley, DeanNational University of Ireland Maynooth2020

    … in eukaryotes are the mitogen-activated protein kinase (MAPK) pathways. MAPK pathways are responsible for the regulation of a diverse array of biological processes, such as cell proliferation, immune responses and metabolism, to name a few. In fungal organisms, MAPK pathways have been shown to be …

    maynooth Repository record

  13. Regulation and communication between the NRD kinase COT1, the MAK2 MAP kinase and the Striatin complex in Neurospora crassa

    Dettmann, Anne2012

    … filamentösen Pilz Neurospora crassa ist die NDR Kinase COT1 an der Koordination der polaren Verlängerung der Hyphenspitze beteiligt und der Verlust der Kinase COT1 führt zur Einstellung der Hyphenspitzenverlängerung und der Ausbildung eines hyperverzweigten Erscheinungsbildes. NDR Kinasen …

    goettingen Repository record

  14. Die Rolle einer konstitutiv-aktiven MAP-Kinase SAPK-Beta bei der zellulären Transformation, Proliferation und Apoptose von NIH-3T3-Fibroblasten

    Rennefahrt, UlrikeUniversität Würzburg

    Bei c-Jun N-terminalen Kinasen (JNKs) (auch als Stress-aktivierte Proteinkinasen SAPKs bezeichnet), handelt es sich um Mitglieder der Mitogen-aktivierten Proteinkinase Familie (MAPK), die die Genexpression als eine Antwort auf eine Vielzahl von physiologischen und nicht-physiologischen Stimuli …

    wurz-thes Repository record

  15. The Ups and Downs of MAP Kinase ERK: Modulation of Molecular Responses to Song in the Zebra Finch Auditory Forebrain

    Cheng, Hui-YunUniversity of Illinois at Urbana-Champaign2015

    These studies demonstrate that ERK activity in the auditory forebrain reflects information about the familiarity and significance of a specific birdsong stimulus. Moreover, ERK activation appears to be necessary, but perhaps not sufficient, for triggering of an IEG response to song presentation. …

    uiuc Repository record

  16. Ischämie- und Reperfusionsschaden im porcinen ex-vivo-Hämoperfusionsmodell unter Gabe eines p38-MAP-Kinase-Inhibitors - Verhalten der hämodynamischen und physiologischen Parameter

    Klöpfer, DésiréeUniversität Ulm

    ulm-diss Repository record

  17. The Cell Wall Integrity-Associated Map Kinase Homolog, AbSlt2 in the Necrotrophic fungus Alternaria brassicicola is Required for Pathogenicity of Brassicas

    Scott, Derrick CorneliusVirginia Tech2009

    … integrity-associated mitogen-activated protein (MAP) kinase, Slt2 in the yeast, Saccharomyces cerevisiae. This MAP kinase consists of a predicted 1,251-bp open reading frame, and encodes a 416-amino-acid protein weighing 47501 Da. This homolog was designated AbSlt2 (A. brassicicola Slt2) and gene …

    vt Repository record

  18. Macrophage migration inhibitory factor führt in humanen Endothelzellen zur Aktivierung der SRC-Kinase, der PI-3-Kinase und des MAP-Kinase Signalwegs

    Retzmann, DeniseUniversität Ulm

    ulm-diss Repository record

  19. Extracellular Signal-Regulated Kinase 7, A Fast Evolving Map Kinase Under Positive Selection, Is Associated With Multiple Levels Of Honeybee Behavioral Plasticity

    Ebaugh, Jason D.University of Illinois at Urbana-Champaign2009

    Submitted by Jason Ebaugh (ebaugh@illinois.edu) on 2009-07-04T21:26:59Z No. of bitstreams: 1 EbaughJasonDissertation.pdf: 9370507 bytes, checksum: 6fc1987ff7690d3a540912672da149c0 (MD5)

    uiuc Repository record

  20. Characterization of insulin-stimulated protein kinase cascade in normal and diabetic rats and the effects of vanadium

    Hei, Yong-jiangUniversity of British Columbia1993

    Multiple protein kinases acting in a sequential manner have been identified to constitute a kinase cascade that mediates growth factor or mitogen-activated signal transduction. The cascade is triggered at the cell membrane by the activation of receptor tyrosine kinases, which pass on the signal in …

    ubc Repository record

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