Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Mannosyltransferase"”.
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Congenital Disorder of Glycosylation (CDG) - Ih
… activity of the human ortholog of the yeast ALG2 mannosyltransferase which catalyses the transfer of mannose residues onto Man1GlcNAc2-PP-dolichyl at the cytosolic site of the endoplasmic reticulum in the early onset of glycoprotein biosynthesis. The patient presented normal at birth but developed …
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Chemical tools to probe carbohydrate recognition and glycoconjugate biosynthesis
… established radiolabelled assays to detect mannosyltransferase activities involved in the biosynthesis of lipoarabinomannan in Mycobacterium smegmatis and galactosyltransferase activities involved in the decoration of GPI anchor in Trypanosoma brucei. Further application of this methodology …
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Investigating the pathway of asparagine-linked glycoprotein biosynthesis
… pathway genes in yeast, the roles of two mannosyltransferases in the pathway, Alg2 and Algl 1, remained ambiguous. This thesis describes the biochemical studies that were carried out to clarify these roles. The substrate specificity of Algl, the first mannosyltransferase in the pathway, …
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Biochemical and molecular characterisation of cell wall glycosyltransferases in Mycobacterium tuberculosis
… identified to encode for an α(1\(\rightarrow\)6) mannosyltransferase [MptA] involved in the later stages of the biosynthesis of the α(1\(\rightarrow\)6) mannan core of LM/LAM, while Rv1459c/NCgl1505 [MptB] was shown to be involved in the early stages of the biosynthesis of the α(1\(\rightarrow\)6) …
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Characterisation of the cell wall protein Pga29p in the human pathogenic fungus <i>Candida albicans</i>
… O-Mannosylierung von Pga29p durch die Protein-O-mannosyltransferase 1 (Pmt1p) wurde durch Analyse von CWP-Extrakten von C. albicans Mutanten, die defizient sind in ihrer O-Glykosylierung, nachgewiesen. RHE, welches mit dem pga29/pga29 Stamm infiziert wurde, zeigte eine verringerte Expression von …