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Showing 1 to 12 of 12 for “"Mannich bases"”.
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CYTOTOXIC EVALUATION OF SOME MANNICH BASES OF CONJUGATED STYRYL KETONES
… activity. However their corresponding Mannich bases resulted in several analogs with antineoplastic activity and increased avidity for thiols compared to their precursors. Several analogs of Mannich bases were designed on the basis of some of the established approaches in rational drug …
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MANNICH BASES DERIVED FROM STYRYL ALKYL KETONES AND THEIR HYDRAZONE ANALOGS AS POTENTIAL ALKYLATING AGENTS
… for effective and selective anticancer drugs. Mannich bases have been found to display a wide range of biological activities. Earlier work from these laboratories have established the potential of some of these compounds as antineoplastic agents. Based on the kinetic and physicochemical …
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SYNTHESIS OF a,ß-UNSATURATED-1,3-DIKETONES AND RELATED MANNICH BASES FOR EVALUATION AGAINST VARIOUS NEOPLASMS
… toxicity for neoplasms than normal tissues. Mannich bases have been found to display a wide range of biological activities. Earlier workers from these laboratories have established the potentiality of some of these compounds as antineoplastic agents. Based on kinetic and physicochemical …
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A study of the mannich reaction with certain phenols, of the causes of formation of coloured products and the prevention of their occurence
Mannich bases from dimethylamine, formaldehyde and phenol, m-cresol, eugenol, p-tent-pentylphenol, p-tert butylphenol, p-iso-propylphenol, 3,1,5-trimetbylphenol, resorcinol, 3-pentadecylphenol and the component phenols of cashew nut shell liquid (CNSL) have been prepared. Mannich bases have also …
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Totarol as privileged natural product scaffold for antimalarial drug discovery
… of three different compound classes namely: Mannich bases, aminoalcohols and semicarbason derivatives. The aim was to incorporate important drug fragments into a natural product scaffold with intrinsic antiplasmodial activity, possibly leading to the discovery of new totarol based …
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Synthesis and biological evaluation of antiparasitic Cysteine protease inhibitors based on the Isatin Scaffold
… and also a series of isatin-based Schiff and Mannich bases were prepared by reacting selected isatin-3-thiosemicarbazones with formaldehyde and appropriate secondary amines. To compare the effects of replacing the Mannich bases, a similar series of aminoquinolineethylene isatin-based …
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In silico-guided design, synthesis and antimicrobial activity of piperazine-linked 8-hydroxyquinoline-isatin hybrids
… 5- (piperazin-1-ylmethyl)quinolin-8-ol 11. The Mannich reaction of unsubstituted/5- substituted isatin with 11, yielded Mannich bases 14a-c with yields ranging between 56 - 60%. Proposed structures of the novel hybrids, 14a-c were confirmed by means of infrared, 1H- and 13C-NMR spectroscopy. …
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Novel Antimalarial Compounds from the Optimization of the Malaria Box
… C3-ester, C-7 phenol, as well as the phenolic Mannich base moiety. Modifications at phenolic Mannich base moiety leads to the discovery of an analogue that is twice as potent toward cultured P. falciparum compared to MMV665831. We were worried the phenolic Mannich base moiety might act as the …
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Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tuberculosis and malaria
… activity. A fusidic acid anilide formed from the Mannich base, 3-((N,Ndiethylamino)methyl)-4-hydroxy aniline recorded the most potent antimycobacterial activity with MIC90 values of 0.40 µM and 10.35 µM in the 7H9/CAS and 7H9/ADC media, respectively. Meanwhile, multi-stage antiplasmodium activity …