Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Mammary gland development"”.
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Role of Cuzd1 in mammary gland development and tumorigenesis
… the epidermal growth factor (EGF) family control mammary development are unclear. We have identified the CUB and zona pellucida-like domain containing protein-1 (CUZD1) as a target of estrogen regulation in the mouse mammary epithelium. Mice lacking Cuzd1 exhibited a striking impairment in …
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Regulation of Mammary Gland Development and Tumorigenesis By 14-3-3 Zeta
… pathways that play critical roles in organ development are often aberrantly regulated during cancer initiation and progression. 14-3-3z is overexpressed in more than 40% of breast cancers and is associated with poor patient prognosis. Therefore, the function of 14-3-3z in cancer and normal …
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The Role of Exogenous Somatotropin, Ovariectomy and Extracellular Matrix in Bovine Mammary Gland Development
The highly regulated maturation of the mammary gland is poorly understood. Our studies were designed to further characterize the role of ovarian hormones, growth hormone (GH)/IGF axis proteins and extracellular matrix (ECM) in the growth and development of prepubertal mammary glands. Prepubertal …
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Elucidation of mammary gland development: combination of novel techniques to study proliferation and stem cells
The mammary gland is a dynamic organ that undergoes many cycles of proliferation and death throughout both oestrus cycling and the gestation/lactation/involution cycle. Moreover, it is a unique tissue in that the majority of its development occurs postnatally coincident with the production of …
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Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
In the mammary gland, genetic circuits controlled by the hormones, estrogen, progesterone and prolactin (PRL), act in concert with pathways regulated by the epidermal growth factor (EGF) family to control the growth and morphogenesis of this tissue during puberty, pregnancy and lactation. However, …
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
The adult mammary gland is comprised of a bi-layered epithelium of luminal and myoepithelial cells surrounded by an adipocyte-rich fat pad, a highly collagenous extra-cellular matrix (ECM) and a number of other stromal and endothelial cell types. Mammary stem cells (MaSCs) reside within the …
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The Role of Insulin-like Growth Factor-I and IGF-binding Proteins in Mammary Gland Development
Development of the mammary gland is likely mediated by locally produced growth factors acting in concert with circulating mitogens. To investigate the importance of mammary synthesis of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBP), the initial objective was to evaluate the …
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The effects of dietary protein intake by the dam and by the offspring on mammary gland development in young female rats
… of dietary protein (casein) at different ages on mammary gland development in first generation female Sprague Dawley rats. Offspring were fed the same diet as fed to their dams during gestation and lactation, or offspring were crossed over at weaning to different protein intakes, from control dams …
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Detailed analysis of Lmx1b expression in multiple organs and its role in dorso-ventral patterning with emphasis on myogenic precursor cells
… expression is present throughout all stages of mammary gland development and restricted to luminal epithelial cells. Mice targeted for Lmx1b lack mammary glands. These findings indicate that Lmx1b plays a pivotal role in mammary gland development. Indeed, female patients with NPS display poor …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
… tissues are remodelled and repositioned during development. Previous studies have characterised the role of EMT regulators in epithelial plasticity observed during branching morphogenesis in the mammary gland. For example, a microarray analysis of gene expression in terminal end buds identified …
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The Expression of T-Box (Tbx3) in the Bovine Mammary Gland
<p>Development of the bovine mammary gland is a complex process that is regulated by several hormones, growth factors and transcription factors including but not limited to growth hormone (GH), insulin-like growth factor (IGF)-I and T-box (Tbx)2 and 3. Tbx2 and Tbx3 are transcription factors …
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The Effects of Tamoxifen on Mammary Development in Prepubertal Heifers
Our purpose was to determine the effects on mammary gland development in prepubertal heifers given the anti-estrogen tamoxifen. Sixteen Holstein calves were randomly assigned to one of two treatment groups: tamoxifen-injected (TAM) or control (CON). Calves were subcutaneously injected daily from 28 …
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Overexpression of ovine insulin-like growth factor-I (IGF-I) in the mammary glands of transgenic mice
Evidence indicates that the mammary gland may contribute to its own development by the production of insulin-like growth factor-I (IGF-I). To generate a model for investigation of the effects of enhanced IGF-I synthesis in the mammary gland, six transgenic founder mice were produced by …
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Investigating The Roles of Δnp63 As A Suppressor of Migration, Invasion, and Metastasis
… Nonetheless, understanding the basics of tumor development and progression are the key to focused on studying the role of ΔNp63 in cancer, a p53 family member known to be involved in epithelial development, microRNA biogenesis, and stem cell maintenance. Using the strength of <em>in vivo …
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A Morphological Study of Paracrine Interactions in the Anterior Pituitary of Lactating Rats Using Immunogold Techniques
… of prolactin in the female is the stimulation of mammary gland development for lactation. It is well established in the rat that during periods of lactation, when serum prolactin levels are high, there is a suppression of the serum luteinizing hormone level. Prolactin has also been shown to …
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Repressor of Estrogen Receptor Activity (REA) is a gene dose-dependent coregulator protein affecting estrogen signaling and cell survival
… investigated its function in both the uterus and mammary gland by conditional deletion of the REA gene, because the conventional knockout of REA is embryonic lethal. To this end, we generated REAf/f mice and crossed them with PR-Cre knock-in mice as well as WAP-Cre transgenic mice, thereby …
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The Effect of Increased Nutrient Intake and Exogenous Estrogen on Mammary Gland Growth, Morphology, Histology, and Gene Expression of Holstein Heifer calves
… stimuli and will have a more developed mammary gland as a result of imposed treatments. Enhanced-fed calves grew at a faster rate, were heavier at weaning, and had more functional mammary tissue (i. e., parenchyma; PAR) mass in the mammary gland at weaning (7.3-fold). Additionally, …
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Analysis of the Function of Megf7 During Development
… regulator of tissue patterning during embryonic development. Prior to this work, the function Megf7 had largely been unknown. Eight distinct mutations in Megf7 were introduced into mice in order to facilitate a functional analysis of Megf7. The Megf7EC Stop mutant, which has a premature stop …
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ZFAS1: a long non-coding RNA with novel implications for ribosome function
… ZFAS1 that is differentially expressed in mouse mammary gland development and breast cancer. The primary objective of this thesis was to understand how ZFAS1 may contribute to regulation of cellular processes using breast cancer as a model. We have found ZFAS1 expressed in high abundance in all …
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New methods to study human mammary development and breast cancer
… arise from within the normal architecture of the mammary gland and resemble normal mammary epithelial cell types on a molecular and gene expression level. Many tumors become dependent on the signaling pathways that guide mammary differentiation and proliferation, and may be driven by transcription …
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