Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Mammary Development"”.
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New methods to study human mammary development and breast cancer
… arise from within the normal architecture of the mammary gland and resemble normal mammary epithelial cell types on a molecular and gene expression level. Many tumors become dependent on the signaling pathways that guide mammary differentiation and proliferation, and may be driven by transcription …
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The Effects of Tamoxifen on Mammary Development in Prepubertal Heifers
Our purpose was to determine the effects on mammary gland development in prepubertal heifers given the anti-estrogen tamoxifen. Sixteen Holstein calves were randomly assigned to one of two treatment groups: tamoxifen-injected (TAM) or control (CON). Calves were subcutaneously injected daily from 28 …
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Growth Factor and Extracellular Matrix Regulation of Heifer Mammary Development
… matrix proteins in regulating prepubertal heifer mammary development. In the first experiment, short-term treatment of heifers with GH or E increased proliferation of mammary epithelial cells. Coinciding with increased epithelial cell proliferation, IGF-I protein increased and IGFBP-3 protein …
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Innate Immune Cells may be Involved in Prepubertal Bovine Mammary Development
Pre-pubertal bovine mammary development involves ductal and stromal tissue changes. In mice, this process is impacted by presence of innate immune cells. Whether or not such immune cells are present or involved in bovine mammary development is unknown. We studied the presence, location and changes …
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Effects of Milk Replacer Composition on Measures of Mammary Development in Holstein Heifer Calves
… (MR) composition on: mass and composition of mammary parenchyma (PAR) and fat pad (MFP), growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis gene expression, and putative mammary epithelial stem cells. The hypothesis was that diet during the pre-weaning period alters the development, …
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Effects of bodyweight and plane of nutrition on mitogenic capacity of mammary extracts in cell culture, mammary growth and development, and protein expression profiles of mammary tissue in Holstein heifers
Mammary gland samples from a large serial-slaughter Holstein heifer nutrition trial were used to determine the effects of stage of development and nutritional management on mitogenic activity of mammary extracts and mammary parenchymal composition. Stage of development and nutritional management of …
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The physiological role of relaxin in the pregnant gilt: The effects of relaxin on the physical and biochemical properties of the cervix and on mammary development in ovariectomized hormone-treated pregnant gilts
The purpose of this research was to determine the physiological roles of relaxin in pregnant gilts by ovariectomizing gilts during the last third of gestation followed by hormone replacement therapy. Nara and coworkers demonstrated that in pigs ovariectomized in late pregnancy a prolonged delivery …
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Proteomic Analysis of Mammary Epithelial Cell Development
… used to investigate the protein profile of the mammary epithelial cell (MEC) through different stages of mammary development. The HC11 cell line was used to investigate protein changes between undifferentiated and differentiated MEC, which represent the pregnant and lactating states of the …
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Abundance and Localization of (Yes-associated protein) YAP in Prepubertal Bovine Mammary Tissue
Most mammary development is postnatal. Mammary growth that occurs before puberty is diminutive in amount but consequential for future milk production, especially in dairy heifers. With advanced knowledge on fundamental aspects that govern prepubertal mammary development, scientists and farmers …
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New technologies and methodologies for the study of human mammary epithelial differentiation and development
The mammary gland is unique among human tissues in that the bulk of its development occurs postnatally, under hormonal control. The gland consists of an epithelium that expands dramatically during puberty and pregnancy, and is the site of breast cancer initiation. Important connections between …
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Mechanisms Controlling Ductal Morphogenesis in the Ruminant Mammary Gland
… provide a better understanding of this important developmental period. Histologic features of prepuberal ruminant mammary parenchymal morphogenesis were examined in tissue samples taken from ewe lambs at 2 (n = 5), 3 (n = 15), 6 (n = 26), 9 (n = 7), 12 (n = 5), and 13 wk (n = 20), and from …
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Role of Cuzd1 in mammary gland development and tumorigenesis
… the epidermal growth factor (EGF) family control mammary development are unclear. We have identified the CUB and zona pellucida-like domain containing protein-1 (CUZD1) as a target of estrogen regulation in the mouse mammary epithelium. Mice lacking Cuzd1 exhibited a striking impairment in …
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Effects of varying energy intakes on mammary growth and development in prepubertal heifers
… prepuberty has been linked to impairments in mammary development and reductions in milk yield. Our objective was to determine how varying energy intakes between 2 and 14 wk of age affect mammary parenchymal development. At 2 wk of age, Holstein calves were assigned to 1 of 4 treatments (HH, …
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Epithelial and immune cell dynamics in non-traditional models of mammary postnatal development
Mammary terminal duct lobular units comprise an epithelial bilayer of luminal and myoepithelial cells. The specific contribution of each distinct epithelial compartment to mammary postnatal development and the mammary microenvironment remains to be elucidated. The present study aims to exploit the …
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The Effect of Increased Nutrient Intake and Exogenous Estrogen on Mammary Gland Growth, Morphology, Histology, and Gene Expression of Holstein Heifer calves
… stimuli and will have a more developed mammary gland as a result of imposed treatments. Enhanced-fed calves grew at a faster rate, were heavier at weaning, and had more functional mammary tissue (i. e., parenchyma; PAR) mass in the mammary gland at weaning (7.3-fold). Additionally, …
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Lactogenesis Induction in Transgenic Virgin Pigs as a Model for Identifying Transgene Expression and Recombinant Protein Production
The porcine mammary gland can be used for the production of recombinant proteins by directing a transgene to the mammary gland with a milk protein gene promoter. In order to determine whether or not the protein will be expressed, the animals must be maintained at least through their first …
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The effect of ethanol consumption on the development of the female rat mammary gland
… chronically exposed to ethanol-containing diets mammary gland TEB density increased and the density of AVB was decreased. An increase in TEB structures is representative of an undifferentiated gland and are considered susceptible to chemical carcinogen action. Similarly, in the sexually-mature …
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A Proteomic Analysis of Differentiation in the Mammary Epithelium
… changing hormonal environment and the structural development of the mammary gland from pregnancy to lactation, very little is known about the molecular mechanisms governing differentiation of the mammary epithelium into a milk-secreting phenotype. It is important to acknowledge the diversity among …
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Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I
… growth factor-I (IGF-I) signaling in mammary epithelial cells may be modified or interrupted by modifications in the cellular environment may lead to 1) methods to increase the growth and proliferation of normal mammary epithelial cells for an increase in the amount of milk produced on …
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Regulation of Mammary Gland Development and Tumorigenesis By 14-3-3 Zeta
… pathways that play critical roles in organ development are often aberrantly regulated during cancer initiation and progression. 14-3-3z is overexpressed in more than 40% of breast cancers and is associated with poor patient prognosis. Therefore, the function of 14-3-3z in cancer and normal …
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