Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Mammalian target of rapamycin (mTOR)"”.
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The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
The serine-threonine kinase mammalian target of rapamycin (mTOR) is an important integrator of nutrient, cytokine and growth factor sensing in T cells and controls transcriptional programs that determine CD8+ cytotoxic T cell fate and trafficking. mTORC1 is inhibited by the drug rapamycin which is …
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Role of PRAS40 in mammalian target of rapamycin (mTOR) modulation in cancer and insulin resistance
<p>Dysregulation of PI3K-AKT-mTOR pathway has been reported in various pathologies, such as cancer and insulin resistance. The proline-rich AKT substrate of 40-kDa (PRAS40), also known as AKT substrate 1 (AKT1S1), lies at the crossroads of these cascades and inhibits the activity of the mTOR …
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Resistance Training Increases the Expression of AMPK, mTOR, and GLUT4 in Previously Sedentary Subjects and Subjects with the Metabolic Syndrome.
<p>Exercise has been considered a cornerstone of diabetes prevention and treatment for decades, but the benefits of resistance training are less clear. Nineteen non-diabetic subjects (10 metabolic syndrome, 9 sedentary controls) underwent 8 weeks of supervised resistance training. After training, …
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Dysregulated DJ1-Mediated Translation in Alzheimer's Disease
Alzheimer’s Disease (AD) is a form of dementia with aberrant synaptic transmission. It has been hypothesized that disrupted calcium signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis …
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The effect of mTOR inhibitor rapamycin on a dietary Drosophila melanogaster model of calcium oxalate nephrolithiasis
Impaired cellular tolerance of reactive oxygen species (ROS) has been suggested as a common mechanistic link associated with aging in both metabolic syndrome and nephrolithiasis. The mechanistic (mammalian) target of rapamycin (mTOR) activity is characteristic of metabolic syndrome. When nutrients …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… glucose and structurally by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth in the heart is the mammalian target of rapamycin (mTOR), which couples energy and nutrient …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
<p>Compulsivity is a feature of many psychiatric disorders, resulting in distressing and challenging to treat symptoms. Compulsivity is a key feature of obsessive compulsive disorder, which can hinder a person's life and ability to work. Selective serotonin reuptake inhibitors are the current …
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Protein feeding and exercise recovery
The importance of protein feeding for maximising the anabolic effect of resistance exercise is well established. Ingestion of amino acids or intact protein sources with and without carbohydrate during exercise recovery further stimulates muscle protein synthesis. Less clear is the impact of an …
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Measuring the effects of drugs on single cancer cell growth
Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response of a cell population which can mask the heterogeneity and dynamics of …
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Screens for non-eukaryotic initiation factor two alpha dependent activation of ATF4 translation
… I investigate these questions using two models of eukaryotic cell stress: the integrated stress response (ISR) and mammalian target of rapamycin (mTOR) pathway in H. sapiens, and the environmental stress response (ESR) and heat shock response (HSR) in S. cerevisiae. I first establish a CRISPRi …
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Examination of the effect of a diet high in vitamin D in a preclinical model of fragile X syndrome.
… disorders affect approximately 17% of the population. Fragile X Syndrome (FXS) is a genetic neurodevelopmental disorder that is the most common form of inherited intellectual disability and is a monogenic cause of autism spectrum disorder (ASD). Individuals with FXS lack the ability …
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Oligodendrocytes of the adult hypothalamic median eminence
The median eminence (ME) of the hypothalamus is a dynamic structure able to rapidly respond to nutrient availability. Both immature oligodendrocyte precursor cells (OPCs) and mature myelinating oligodendrocytes (MOLs) are found in this region in adults. While proliferation of ME OPCs has been shown …
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Effects of physical activity levels and nutritional intake on skeletal muscle protein turnover and cellular signaling
Loss of muscle mass is common in many clinical conditions such as cancer, AIDS, burns and paralysis as well as in aging. Decreased muscle mass can contribute to many other complications and co-morbidities related to diseases, trauma and aging including overall weakness, immobility, increased risk …
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The Contribution of Spleen Tyrosine Kinase to the Pathobiology of Alzheimer’s Disease
… disease that accounts for most cases of dementia. The pathological hallmarks of AD include extracellular A-beta plaques, intracellular tau accumulations or neurofibrillary tangles, as well as neuroinflammation. As of 2018, there exists no disease modifying treatment for AD and the …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… elements for proper migration and recruitment of neutrophil cells, the underlying signaling networks remain poorly defined. We have identified Pyk2, a FAK (focal adhesion kinase) family non-receptor tyrosine kinase, as a beta2-integrin-dependent regulator of rear contraction in migrating …
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Association of Protein Phosphatase 2A with S6 Kinase Is Regulated In an MTOR-Dependent Manner
The mammalian target of rapamycin (mTOR) pathway senses nutrient and growth factors to regulate protein synthesis and cell growth. Strict control of the components of this pathway is essential for cells to reach an appropriate size. Aberrant mTOR signaling has been implicated in multiple diseases …
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Autophagy and Inflammation During Rickettsial Infection
… bacteria that replicate in the cytoplasm of host cells. In my dissertation, I have studied the induction of autophagy by rickettsiae as well as the role of autophagy in the pathogenesis of rickettsioses in vitro and in vivo. I found that autophagy is induced in murine bone marrow …
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Mechanisms of pain processing: spinal protein translation in the rat
… by the International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Shifts in pain thresholds and responsiveness are an expression of neural plasticity, a process …
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The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… alcohol regulates telomerase activity via the mammalian target of rapamycin (mTOR) pathway in prostate cancer cells. Telomerase–the enzyme responsible for immortalizing cells through telomeric repeats addition–is de-repressed early in an aspiring cancer cell. We hypothesized that perillyl …
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The role of mTOR signaling in Alzheimer s disease
The majority (>95%) of Alzheimer s disease (AD) cases are sporadic and of unknown causes. The single major risk factor for AD is aging and molecular changes that occur in the brain as a function of age may facilitate the development of AD. However, little is known as to how the aging process …
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