Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Mammalian physiology"”.
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Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
… to the maintenance of a stable cellular genome. Mammalian cells have evolved a sophisticated DNA damage response (DDR) network that senses the physical existence of DNA DSBs, followed by signal propagation to repair these genetic lesions. Interestingly, DSBs are not only hazardous, but are also …
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Circadian rhythms of redox state and regulation of neuronal excitability in suprachiasmatic nucleus of rodents
Daily rhythms of mammalian physiology, metabolism, and behavior parallel the day-night cycle. They are driven by the central circadian clock in the brain, the suprachiasmatic nucleus (SCN), where a genetic oscillator plays an essential role. Clock-gene transcription/translation is sensitive to …
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Evolutionary signatures for unearthing functional elements in the human transcriptome
… identifying the regulatory mechanisms crucial to mammalian physiology, and deciphering how gene regulation contributes to the diversity of mammalian phenotypes. For my thesis, I developed two methodologies for interrogating comparative transcriptomic data for biological inference. First, I …
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Nutrient sensing by the mTORC1 pathway in physiology
… implications of nutrient sensing by mTORC1 in mammalian physiology remains poorly understood. Here, we identified a critical role of leucine sensing by mTORC1 in adapting to leucine availability in vivo. Mice lacking the leucine sensors Sestrin1 and Sestrin2 fail to inhibit mTORC1 in tissues …
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Bioorthogonal Chemical Reporters Reveal Fatty-Acylation of Histone H3 Variants and Cholesterol Modification of Proteins and Trafficking in Cells
… greater diversity of lipid-modified proteins in mammalian cells than had previously been appreciated. Proteins targeted by a series of fatty acid chemical reporters ranging from myristic to stearic acid showed their involvement in a vast range of cellular processes from all cellular compartments. …
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A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor
… play an essential role in the regulation of mammalian physiology. In the brain, MR-mediated neurotransmission is required for the control of movement and motivated behavior by the basal ganglia, and MR dysfunction may contribute to schizophrenia, Alzheimer's disease, and motor disorders. …
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Catecholamine physiology in the sheep
A study of catecholamine physiology in the sheep has been carried out with emphasis on the measurement of plasma catecholamine levels and their interactions with lactic acid and cortisol. The plasma dynamics of the catecholamines were first examined under laboratory conditions followed by an …
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Capillary electrophoresis instrumentation and applications for the analysis of neural systems
… a variety of model systems. Using the mouse as a mammalian model, we have demonstrated a significant, non-neuronal source of serotonin to the hippocampus from nearby mast cells, a major component of the immune system. Also, using a genetically modified strain of Drosophila melanogaster, we have …
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Molecular and Genetic Analysis of Neuropeptide Signalling in Mammalian Circadian Timekeeping
… nucleus (SCN) of the hypothalamus is the master mammalian pacemaker, co-ordinating the multitude of cell-autonomous circadian oscillators across the body to ensure internal synchrony, as well as maintaining an adaptive phase relationship with the light-dark cycle via projections from the retina. …
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Investigating the role of PABPC5 in mouse physiology
… literature characterising the role of PABPs in mammalian physiology. PABP5 is another member of the PABP family. It is mammalian-specific, and it is structurally different to other PABPs, but little is known about its function. PABP5 resides in the gene-poor region of Xq21.3 and published data …
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Role of PABP4 in intrauterine growth restriction
… the roles of these so-called “somatic PABPs” in mammalian physiology. Here, we aim to address this, building on unpublished data in our Pabp4-/- mice by investigating its surprising requirement for the establishment/maintenance of healthy pregnancy. Previous work in the lab has shown that …