Global ETD Search
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Showing 1 to 6 of 6 for “"Mammalian complex I"”.
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Developing mouse complex I as a model system: structure, function and implications in mitochondrial diseases.
Complex I (NADH:ubiquinone oxidoreductase), located in the mitochondrial inner membrane, is a major electron entry point to the respiratory chain. It couples the energy released from electron transfer (from NADH to ubiquinone) to the concomitant pumping of protons across the membrane, to generate …
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Pharmacological aspects of the inhibition of mammalian respiratory complex I
Mitochondrial complex I, a large respiratory enzyme located in the inner mitochondrial membrane, catalyses electron transfer from NADH to ubiquinone while concomitantly translocating protons across the membrane to sustain ATP synthesis. A crucial aspect of the pharmacology of complex I is …
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Using molecular approaches to understand Complex I deficiency in mouse models
Complex I (NADH:ubiquinone oxidoreductase), a major electron entry point to the mitochondrial respiratory chain, couples electron transfer from NADH to ubiquinone to proton pumping across the mitochondrial inner membrane, and generates the proton motive force that drives ATP synthesis and transport …
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Structural Studies into the Mechanism and Organisation of Mammalian Respiratory Complex I
Respiratory complex I (NADH:ubiquinone oxidoreductase) is the major entry point of electrons into the electron transport chain and couples its redox activity with proton pumping across the inner mitochondrial membrane, thus contributing to the proton motive force which drives ATP synthesis. With …
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Studies on assembly and genetic variation in mitochondrial respiratory complex I
Complex I (NADH:ubiquinone oxidoreductase) couples electron transfer to proton translocation across the inner mitochondrial membrane, to drive the synthesis of ATP. Its distinctive L-shaped structure comprises 45 subunits, encoded by both the mitochondrial and nuclear genomes, which are assembled …
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Cryo-EM studies of substrate and inhibitor binding to mammalian respiratory complex I
Mammalian respiratory complex I (NADH:ubiquinone oxidoreductase) is an intricate multi-subunit, energy-transducing membrane protein that is essential for aerobic energy metabolism and NADH/NAD⁺ homeostasis. It couples the energy released from NADH oxidation and ubiquinone (Q) reduction to pump four …