Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"Mammalian Target of Rapamycin"”.
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The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
The serine-threonine kinase mammalian target of rapamycin (mTOR) is an important integrator of nutrient, cytokine and growth factor sensing in T cells and controls transcriptional programs that determine CD8+ cytotoxic T cell fate and trafficking. mTORC1 is inhibited by the drug rapamycin which is …
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Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin
… further investigated the regulation and function of mTOR cytoplasmic-nuclear shuttling. A systematic screen of mTOR revealed a rev-like NES sequence within mTOR at amino acids 1281--1289, which displayed robust nuclear export activity in a reporter system. Mutation of the conserved leucines within …
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The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease
… and cell growth. We have found that inhibition of mTORC 1 with rapamycin treatment suppressed whole-body postnatal growth similar to reduced caloric intake. We found that while feeding activated mTORC 1 in almost every tissue, there was variability in the upstream activating stimuli. The role of …
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Role of PRAS40 in mammalian target of rapamycin (mTOR) modulation in cancer and insulin resistance
<p>Dysregulation of PI3K-AKT-mTOR pathway has been reported in various pathologies, such as cancer and insulin resistance. The proline-rich AKT substrate of 40-kDa (PRAS40), also known as AKT substrate 1 (AKT1S1), lies at the crossroads of these cascades and inhibits the activity of the mTOR …
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Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes
The mammalian target of rapamycin (mTOR) is an intracellular protein kinase that plays a key role in the control of cell growth, differentiation, cell survival, and cell proliferation. In humans, mTOR deregulation is implicated in parasitic, fungal, bacterial and viral infections, immune disorders, …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… elements for proper migration and recruitment of neutrophil cells, the underlying signaling networks remain poorly defined. We have identified Pyk2, a FAK (focal adhesion kinase) family non-receptor tyrosine kinase, as a beta2-integrin-dependent regulator of rear contraction in migrating …
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Insulin and TSH signal transduction pathways in human preadipocytes.
Signaling through the rapamycin-sensitive mammalian target of rapamycin-p70 S6 kinase (p70 S6K) pathway was examined in human preadipocytes in primary culture. The inhibitory effect of rapamycin on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal …
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Resistance Training Increases the Expression of AMPK, mTOR, and GLUT4 in Previously Sedentary Subjects and Subjects with the Metabolic Syndrome.
<p>Exercise has been considered a cornerstone of diabetes prevention and treatment for decades, but the benefits of resistance training are less clear. Nineteen non-diabetic subjects (10 metabolic syndrome, 9 sedentary controls) underwent 8 weeks of supervised resistance training. After training, …
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Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
… depressive disorder (MDD) is a leading cause of disability worldwide, with nearly one-third remaining treatment-resistant. Chronic stress is a major risk factor for MDD, whereas acute stress is adaptive and mediated by hypothalamic-pituitary-adrenal axis activation. Ketamine produces rapid …
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Dysregulated DJ1-Mediated Translation in Alzheimer's Disease
Alzheimer’s Disease (AD) is a form of dementia with aberrant synaptic transmission. It has been hypothesized that disrupted calcium signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis …
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The effect of mTOR inhibitor rapamycin on a dietary Drosophila melanogaster model of calcium oxalate nephrolithiasis
Impaired cellular tolerance of reactive oxygen species (ROS) has been suggested as a common mechanistic link associated with aging in both metabolic syndrome and nephrolithiasis. The mechanistic (mammalian) target of rapamycin (mTOR) activity is characteristic of metabolic syndrome. When nutrients …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… glucose and structurally by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth in the heart is the mammalian target of rapamycin (mTOR), which couples energy and nutrient …
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Investigating The Dysregulation And Therapeutic Potential Of Neuroprotective Stress Response Proteins In Huntington’s Disease
… models, apoptotic pathways are dysregulated and mammalian target of rapamycin complex 1 (mTORC1) activity is reduced. These pathways are of particular interest because they regulate cell survival and metabolism, and enhancing mTORC1 is protective in HD models. RNA binding motif protein 3 (RBM3) …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
<p>Compulsivity is a feature of many psychiatric disorders, resulting in distressing and challenging to treat symptoms. Compulsivity is a key feature of obsessive compulsive disorder, which can hinder a person's life and ability to work. Selective serotonin reuptake inhibitors are the current …
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Protein feeding and exercise recovery
The importance of protein feeding for maximising the anabolic effect of resistance exercise is well established. Ingestion of amino acids or intact protein sources with and without carbohydrate during exercise recovery further stimulates muscle protein synthesis. Less clear is the impact of an …
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Measuring the effects of drugs on single cancer cell growth
Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response of a cell population which can mask the heterogeneity and dynamics of …
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Screens for non-eukaryotic initiation factor two alpha dependent activation of ATF4 translation
… I investigate these questions using two models of eukaryotic cell stress: the integrated stress response (ISR) and mammalian target of rapamycin (mTOR) pathway in H. sapiens, and the environmental stress response (ESR) and heat shock response (HSR) in S. cerevisiae. I first establish a CRISPRi …
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Ankyrin-B and Mtor Complex 1 In The Regulation of Electrical Activities In The Heart
<p>The mammalian target of rapamycin complex 1 (mTORC1) activity is paramount in the regulation of electrical activities in the brain and the heart. In the brain, the tumor suppressor gene <em>TSC2</em> encodes the protein product tuberin that interacts with hamartin to form a heterodimer Tuberous …
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Intramuscular Anabolic Signaling and Endocrine Response Following Different Resistance Exercise Protocols In Trained Men
The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway appears to be the primary regulator of protein synthesis and growth. While resistance exercise paradigms are often divided into hypertrophy (HYP) and strength (STR) protocols, it is unknown whether these protocols …
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Cell Cycle Progression Effects of Albumin
<p>Progression through G<sub>1</sub> phase of the cell cycle is controlled largely by growth factors in early G<sub>1</sub> and by nutrients in late G<sub>1</sub> indicating sufficient raw material for cell division. We previously mapped a late G<sub>1</sub> cell cycle checkpoint for lipids …
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