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Showing 1 to 20 of 45 for “"Malonate"”.
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Derivatives of Isopropylidene Malonate
Made available in DSpace on 2014-12-05T19:36:50Z (GMT). No. of bitstreams: 1 5801715.pdf: 1872454 bytes, checksum: 7cf05d084fb38d6c42ac4ba86ce1e70d (MD5) Previous issue date: 1958
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Chemistry of Isopropylidene Malonate and Its Derivatives
Made available in DSpace on 2014-12-05T19:37:36Z (GMT). No. of bitstreams: 1 6100143.pdf: 3886907 bytes, checksum: 8726fdba916a90078de55491ad087186 (MD5) Previous issue date: 1960
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The effects of acetate and malonate on growth and fatty acid biosynthesis in Aspergillus niger
The purpose of this research was to determine the effects of adding alternate carbon sources to a ten percent glucose or sucrose medium on growth, fatty acid distribution, and incorporation of radioactive carbon sources into lipids using submerged Aspergillus niger cultures.
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Developing drugs to attenuate succinate accumulation and oxidation
… to succinate or the classical SDH inhibitor, malonate. Interestingly, only malonate and oxaloacetate showed potent SDH inhibition, thus were selected for further development. Malonate ester prodrugs with different properties were characterised. Hydrolysis rates of the esters differed greatly, …
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Part I : Isolation Of Dipentyl 2-(4-(pentan-3-yl) Phenyl) Malonate From Sanguisorba Officinalis Labill Part II: Synthesis Of A Novel Family Of Ethers Of Podocarpic Acid
… structure dipentyl 2-(4-(pentan-3-yl) phenyl) malonate. The goal of part II of this thesis was to synthesize novel ethers of podocarpic acid. Ethers are of great interest in biological studies and pharmaceutical applications because of their wide variety of uses in the treatment of various …
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Targeting Mitochondrial ROS Production in Kidney Transplantation
… The aim of this thesis was to determine whether malonate ester prodrugs, which competitively inhibit SDH, may reduce mitochondrial ROS production and ameliorate IRI in models of kidney transplantation. Herein, I show that the metabolic changes required for mitochondrial ROS production on …
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Synthesis of chiral phosphino-sulfoximines through phospha-Michael addition and their evaluation as 1,5-P,N-Ligand in asymmetric allylic alkylation
… acetate with dimethyl malonate. The corresponding malonate was obtained with enantiomeric excess (ee) up to 89%. Moreover, the following conclusions were drawn: 1) A matched and mismatched configuration of the ligand was observed. 2) The ee of the corresponding malonate …
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The use of chiral auxiliaries in the synthesis of chemically and biologically important chiral compunds
… imidazolidinone-CA was utilised in developing a malonate-based methodology to synthesise compounds containing a quaternary stereogenic centre (QSC). With this methodology, a small library of malonate-based QSC-containing synthons has been synthesised in both high yields (> 87 %) and high …
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New methodology for the synthesis of chiral, non-racemic a-tertiary amine centres: application to the synthesis of the marine alkaloid lepadiformine
… diastereoselective alkylation of an auxiliary-malonate, in which an imidazolidinone auxiliary provided excellent facial selectivities in the alkylation in conjunction with KHMDS as the base. Five derivatives were generated in high yields (>85 %) and selectivities (dr >95:5). Extension of the …
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Action potentials as indicators of metabolic perturbations for temporal proteomic analysis
… upon exposure to 2DG compared to cyanide and malonate as these cells have elevated glycolysis. A combinational treatment of 2DG, cyanide and malonate had a much higher and faster effect on the cells. A time-dependent change in neuronal action potentials occurred based on the inhibited pathway. …
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Methodology studies on the synthesis of chiral, non-racemic aza-quaternary centres
… -controlled approach based on using chiral malonate -imidazolidinones as a template for amination. Using KHMDS as base it has been shown that the enolate of α -substituted chiral malonate-imidazolidinones can be azidated with trisyl azide in excellent diastereoselectivity in yields > 92 % …
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Tandem Cycloaddition Chemistry of Nitroalkenes: Total Synthesis of (+)-1-Epiaustraline and Synthesis of the Pentacyclic Core of (+/-)-Scandine
… 4.8% overall yield from 2,4-pentadienyl dimethyl malonate.
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Ligand Dependent Regioselectivity in Palladium Mediated Allylic Alkylation
… were applied in the allylic alkylation using malonate nucleophiles. The regioselectivity was shown to depend mainly on steric interactions rather than the electronic effects from the different ligands. In the complexes with less steric interactions, selectivity arising from the trans effect …
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Reactivity of the Vinylogous Epoxyketone Moiety
… of a soft nucleophile, the enolate of diethyl malonate, was not explained by the HSAB theory but by other factors such as ring strain and steric hindrance of the epoxide ring.
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Syntheses of Multi-headed, Two-tailed, Anionic Surfactants as Topical Microbicides
… Commercially available diethyl malonate and straight chain alkyl bromide were selected to produce dialkylacetic acid. Sodium methoxide (MeONa) was used as a base to deprotonate the acidic protons of diethyl malonate. The monoalkylmalonate (RCH(COOEt)2) was separated by vacuum …
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Preparation and properties of N-pentafluorosulfanylamido derivatives
… Attempts at reacting the urea with ethyl malonate, malonic acid, malonyl chloride, carbon suboxide, and ethyl crotonate all failed. The urea was found to be unstable in both acidic and basic media. N,N’-Bis(pentafluorosulfanyl)malonamide was prepared from pentafluorosulfanylamine and …
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The Stetter reaction : synthesis of complex spiro Bis-indanes and studies on quaternary centre formation
… of β,β-disubstitued Meldrum’s acid, diethyl malonate, and malononitrile alkylidenes as well as diphenylcyclopropenone and 3-phenylcyclobutenone as acceptors in the Stetter reaction are discussed.
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Derivatives of 1-(3-methoxy-4-acetoxyphenyl)-2,6-dicarbethoxy-cyclohexanedione-3,5
… (VII). They reacted vanillin with diethyl malonate to form Ethyl- (3-Methoxy-4-hydroxy)-benzalmalonate (v). (V) was acetylated to form Ethyl-(3-Methoxy-4-acetoxy)-benzalmalonate (V). (V) was reacted with acetoacetic ester and sodium ethoxide to give (VII). The object of this investigation …
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