Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Malignant Tumor"”.
-
Manometric Studies of Earle's Strain L Sarcoma Cells
In his classic report, "Metabolism of Tumors" in 1925, Warburg postulated several generalizations concerning malignant tumor tissue metabolism, and summarized from his studies that "interference with the respiration in growing cells is, from the standpoint of the physiology of metabolism, the cause …
-
Micro-analysis of adenylate cyclase and cyclic AMP-dependent protein kinase activities in human mammary tumors
… cAMP-dependent protein kinase within a series of malignant and benign human mammary tumors. The methods allow for determination of enzyme activity in histologically-confirmed neoplastic areas within individual tumors which permits comparisons to be made with particle and cytosolic fractions …
-
Molecular Dynamics of p21 and Fluorescent Sphingomyelin in Keratinocytes Exposed to UVB
… skin cancer (NMSC) is the most common malignant tumor, representing more than a third of all malignant tumors combined and the incidence is increasing every year. Ultraviolet (UV) radiation from the sun is the most dominant factor contributing to tumor initiation and progression. The …
-
Breast Cancer Classification of Mammographic Masses Using Circularity Max Metric, A New Method
… two categories. The first category is a benign tumor, and the other is a malignant tumor. The main purpose of breast cancer classification is to classify abnormalities into benign or malignant classes and thus help physicians with further analysis by minimizing potential errors that can be made …
-
Clinical and Biological Patterns in Soft Tissue Sarcoma
Soft tissue sarcomas (STSs) are rare malignant tumors, of which 3/4 are high-grade and 1/3 metastasize. For optimal management, STSs should be treated at multidisciplinary sarcoma centers. Study I demonstrated that simple referral guidelines, an open-access outpatient clinic and repeated educative …
-
Dosimetry calibration for low-energy protons produced in the ECU accelerator laboratory
… employed in radiation therapy to destroy malignant tumor cells. Among the available modalities, proton and heavy-ion beams produced by particle accelerators have been widely recognized as highly effective techniques for cancer treatment. A key advantage of these particle beams is their …
-
Algorithms for phylogenetic tree correction in species and cancer evolution
… One notable example is in the development of a malignant tumor; tumor cells rapidly grow and divide, acquiring new mutations with each subsequent generation. Tumor cells then compete for resources, often resulting in selection for more aggressive cell types. Recent advancements in sequencing …
-
Development of Bio-Impedance microprobes for Integration with a Smart Biopsy tool
… blood circulation during its retraction from the tumor. These few cancer cells can then serve as seeds for the malignant tumor to grow in the healthy tissue. Cauterization using extreme heat or cold can destroy cells in the region and minimize the chance of seeding but this can be an inexact …
-
CLASSIFICATION OF PATIENTS WITH PAROTID CANCER USING DYNAMIC CONTRAST AND DIFFUSION EXAMINATIONS WITH RADIOMICS AND MACHINE LEARNING TECHNIQUES
… differentiate pleomorphic adenoma (A), Warthin’s tumor (W) and malignant (M) tumors. Materials and Methods: This retrospective study involving 41 patients (19 male, 22 female, age 18–88, median 59.4) with parotid gland lesions (10 W, 15 A and 18 M) who underwent a neck MRI examination at San Paolo …
-
Multiomic Analyses Reveal Epigenomic Alterations and New Targets of Polycomb Repressive Complex 2 in Schwann Lineage Cells and Malignant Peripheral Nerve Sheath Tumors
Malignant peripheral nerve sheath tumors (MPNST) are lethal soft tissue sarcomas occurring in 5-13% of Neurofibromatosis Type I (NF1) patients. It is thought that MPNSTs develop from benign precursors. However, the existing histologically defined stages in MPNST development need improvement. …
-
Prostate Specific Membrane Antigen (PSMA): Immunoassay Development and Characterization of Transcriptional Regulation
… Biomarkers that can discriminate benign from malignant tumor and signal the development of androgen independent and metastatic tumor are needed. A biomarker designated prostate specific membrane antigen (PSMA) has the potential to fulfill this need. The objective of this study is to develop a …
-
The Role Of ROS-mediated ERK and JNK Activation In The Induction Of Autophagy And Apoptosis In Tumour Cells By A Novel Small Molecule Compound
… that chemotherapy-induced reduction in tumor load is a function of apoptotic cell death, orchestrated by intracellular caspase proteases. However, the effectiveness of some of these therapies is blunted by mutations affecting specific effectors genes controlling and/or regulating …
-
Characterising Peritumoural Progression of Glioblastoma using Multimodal MRI
Glioblastoma is a highly malignant tumor which mostly recurs locally around the resected contrast enhancement. However, it is difficult to identify tumor invasiveness pre-surgically, especially in non-enhancing areas. Thus, the aim of this thesis was to utilize multimodal MR technique to identify …
-
Three essays on the effects of health policy on health care financing, demand, and provision
… indicated that being diagnosed with cancer or malignant tumor plays the most important role in influencing patients’ decisions. Concurrently, a high reimbursement rate of health insurance obviously encourages patient mobility. Different from the positive effect of being diagnosed with cancer or …
-
Screening and Functional Study of the Genes inducing Malignant Degeneration of Neurofibromatosis Type 1
… NF1 is notable for the existence of a gradual malignant degeneration of normal and/or benign tumor cells. Three pathological phenotypes of fibroblast cells, normal, benign and malignant, are exist within an individual despite they bare an identical germ line mutation. The influence of …
-
Caratterizzazione proteomica di fluidi e tessuti in diverse condizioni fisio-patologiche
… from birth up to adult age, and pediatric brain tumor tissues. The first study has been performed in order to compare the acid-insoluble fraction of saliva from preterm with at-term newborns and adults and establish if differences exist. In the second study medulloblastoma and pilocytic …
-
Employment quality in adult survivors of childhood cancer
Background: Adult survivors of childhood cancer can have lower employment participation outcomes including employment quality. This study is aimed to identify factors that predict employment quality in this growing population. Methods: Retrospective cohort study of 296 currently employed adult …
-
TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
<p>Biliary tract cancer (BTC) is malignant tumor that originates from the biliary tract, including cholangiocarcinoma (CCA) and gallbladder cancer (GBC). In this translational research program targeting BTC, we focus on three aspects: the development of a combination treatment against CCA, the …
-
Deciphering the Functions of Ets2, Pten and p53 in Stromal Fibroblasts in Multiple Breast Cancer Models
… majority of early studies have focused on the malignant tumor cells themselves, and much has been learned concerning mutations, amplifications and other genetic and epigenetic alterations of these cells. However more recent work has acknowledged the strong influence of tumor stroma on the …
-
INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… plays a pivotal role in the regulation of tumor cell adhesion, migration, invasion, survival and in the homeostasis of the angiogenic endothelium. The cross-talk between integrins and growth factors or cytokines receptors plays an important role also in the biology of several host cell …