Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Malignant Phenotype"”.
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Nanoparticle-Based Drug Delivery and the Impacts on Cancer Cell Biophysical Markers
… assay to define biophysical signatures of malignant cells and monitor the therapeutic efficacy of drugs. Here, we monitored the dynamic cellular biophysical markers in response to sphingosine kinase inhibitors (SphKIs), and compared the effectiveness of drug delivery using …
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Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer
… ductal carcinoma</p> <p><em>in situ </em>(N=13), malignant ovarian cancer (N=12), and benign ovarian tumors (N=9), via IRB-approved and informed consent protocols through M.D. Anderson Cancer Center, as well as normal donor plasmas purchased from Gulf Coast Regional Blood Center (N=6), has allowed …
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Demonstration of new subtypes of adenovirus 7 in South Africa, and probing oesophageal carcinoma cell lines for evidence of adenovirus or of other oncogenic viruses
… did not play a role in the maintenance of the malignant phenotype of the 3 extensively passaged cell lines. Cells of the 3 oesophageal tumor lines were further examined by transmission electron microscopy, but the presence of virus particles in these cells was not observed.
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Expression of Aldehyde dehydrogenase (ALDH) in the breast stem cell line D492 and relations to stem cell properties
… to arise from normal stem cells and acquire a malignant phenotype through series of genetic mutations. Current therapies often fail to eradicate CSCs causing metastatic relapse. Further characterization of mammary stem cells (MaSC) may increase the understanding of normal and cancer stem cells …
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THE METHIONINE CYCLE AS A NOVEL THERAPEUTIC TARGET IN NPM1C DRIVEN ACUTE MYELOID LEUKEMIA
… of a physiological SAM/SAH ratio reverts the malignant phenotype of NPM1c-AMLs. Using engineered AML cells that allow degradation of NPM1c or its ectopic expression, we demonstrated that NPM1c is directly responsible for: i) the cytoplasmic mis-localization of Methionine Adenosyltransferase 2A …
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The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.
… of the invasive process, which is part of the malignant phenotype, and the uPA receptor (uPAR) plays a central role in cell migration. We studied the role of EGF and estrogen on cell migration and uPAR expression in ovarian cancer cell lines. We also analyzed the diagnostic and prognostic value …
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Identification of tumour-associated gycoproteins recognised by the lectin from Helix pomatia in breast cancer
… the HPA binding epitopes associated with a malignant phenotype may be useful for prognostication and may also offer potential as targets for immunotherapy. Previous studies have shown that HPA recognises a multitude of proteins in colorectal cancer (CRC). This study aimed to establish …
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Signaling crosstalk in cancers
… of cellular signaling contributes to the malignant phenotype of cancer. In this dissertation, cross-talk among oncogenic signaling pathways was investigated in two common human cancers. \r\n Pancreatic cancer has a well known spectrum of genetic alterations, among which KRAS mutation is …
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Effects of Oncostatin-M Receptor overexpression on cervical squamous cell carcinoma cells and their extracellular vesicles
… STAT3 and MAP-kinase pathways and induces a pro-malignant phenotype including increased cell migration, invasion and angiogenesis. Bidirectional communication between cancer cells and cells of the tumour microenvironment (TME) is essential for tumour progression. There is mounting evidence to …
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Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
… choices, including the stepwise acquisition of a malignant phenotype, are made by single cells. These studies were carried out culturing cells either in a self-renewal condition or in differentiating condition since the previously reported requirement of myeloid differentiation for AML …
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
… the expression of SRC-3 played a role in the malignant phenotype of these cancers. siRNA-mediated down-regulation of SRC-3 in high-expressing tumor cells significantly inhibited tumor cell growth and induced apoptosis. The effect of SRC-3 down-regulation on cell phenotypes correlated with a …
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Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
… of these mutations in the development of the malignant phenotype. This first pass analysis of the OAC genome has highlighted novel mutational signatures that point to the central role of the unique mutagenic exposures seen in OAC. Most importantly I have shown that the majority of OAC drivers …
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Evaluating the Effects of Fluid Shear Stress on Ovarian Cancer Progression and Metastatic Potential
Most women die of ovarian metastasis rather than the effects of the primary tumor. However, little is known about the factors that support the survival and secondary outgrowth of exfoliated ovarian cancer cells. In addition to genetic and molecular factors, the unique environment of the peritoneal …
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CALCIUM SENSING RECEPTOR FUNCTION IN COLON: A ROBUST PROMOTER OF DIFFERENTIATION AND TUMOR SUPPRESSOR
… Recent studies show that CaSR suppresses the malignant phenotype through a variety of pathways that inhibits growth and promotes differentiation. CaSR also promotes cytotoxic response to fluorouracil. These studies, taken together, have led me to formulate the following working hypotheses: …
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REGULATION OF CANCER METASTASIS BY PROTEIN KINASE D1: A GLOBAL REGULATORY CASCADE
… leads to transformation of cells from normal to malignant phenotype, thereby leading to increased proliferation, growth and metastasis to distant organs of these cancer cells. Literature evidence also points to the fact that E-cadherin β-catenin and PKD1 play a role in regulation of epithelial …
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… develop a multitude of CNS tumors, including malignant peripheral nerve sheath tumors similar to patients with a form of Neurofibromatosis. Neurofibromatosis types 1 and 2 are inherited cancer disorders resulting from the inactivation of their specific tumor suppressor genes, NF1 and NF2, …
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APPROACHES OF MODULATION OF THERAPEUTIC TARGETS RELEVANT TO DRUG RESISTANCE
… downstream effects on pathways relevant to the malignant phenotype, with particular reference to the development of resistance. In recent years, the molecular chaperone Hsp90 has emerged as leading example of such a target-specific therapy. Heat-shock proteins are found at increased levels in …