Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Malignant Melanoma"”.
-
Pax3 expression in cutaneous malignant melanoma
… of aberrant PAX3 re-expression in cutaneous malignant melanoma (CMM). The transcription, factor encoded by PAX is amongst the first expressed in the embryo, with a principal role in the development of the melanocytic lineage. We theorised that abnormal re-expression of PAX3, consistently …
-
A Translational Study Evaluating the Uses of Diagnostic and Therapeutic Practices Established in Human Malignant Melanoma in Equine Malignant Melanoma
Malignant melanoma is a neoplasm of melanocytes. It typically originates in skin, but may metastasize to other body systems. It is a relatively common neoplasm in both humans and horses, with striking similarities across both species. Heritable genetic factors associated with melanoma have been …
-
Galectin-3 Enhances The Malignant Melanoma Phenotype By Regulating Autotaxin
<p>In melanoma patient specimens and cell lines, the over expression of galectin-3 is associated with disease progression and metastatic potential. Herein, we have sought out to determine whether galectin-3 affects the malignant melanoma phenotype by regulating downstream target genes. To that end, …
-
Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach.
… The incidence of many cancers, including melanoma, continues to rise, with a huge demand for therapies even if treatment goals are purely cytostatic. One particular therapeutic strategy is the metronomic (continuous and low) dosing of conventional chemotherapy. There is evidence to suggest …
-
The evaluation of targeted radionuclide therapies and radio sensitising agents in malignant melanoma
Introduction: Malignant melanoma is highly resistant to conventional cancer therapies, characterised by a broad spectrum of radio resistance combined with a low response to chemotherapeutics. This state is compounded by inadequate dose delivery of conventional radiotherapy options. A targeted …
-
Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
<p>Metastatic melanoma is amongst the most refractory of cancers. Drug resistance and lack of therapeutic selectivity are two main challenges to successful melanoma therapy. Herein, we investigated the mechanims of anticancer activity and therapeutic selectivity of two novel agents, 3β, 16β, …
-
Malignant melanoma-Risk factors and the CDKN2A mutation in relation to phenotypes and other cancers.
Background: Cutaneous malignant melanoma (CMM) is an increasingly common cancer in fair-skinned people. The purpose of this thesis was to study high-risk patients with multiple tumours including a CMM, high-risk families with the unique Swedish germline mutation in CDKN2A(113insArg), as well as …
-
The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
Malignant melanoma is an invasive type of skin cancer with high mortality rates, if not detected promptly. The mortality trends are generally linked to multiple dysplastic nevi, positive family history, genetic susceptibility and phenotypic features including fair skin, freckles, numerous atypical …
-
The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
Malignant melanoma is an invasive type of skin cancer with high mortality rates, if not detected promptly. The mortality trends are generally linked to multiple dysplastic nevi, positive family history, genetic susceptibility and phenotypic features including fair skin, freckles, numerous atypical …
-
Expression of Cytosolic and Mitochondrial Superoxide Dismutases: Their Role in the Chemoresistance of Malignant Melanoma
In summary, MM cells that are exposed to sublethal doses of ROS generating chemotherapeutic agents are able to modulate antioxidant defenses as an adaptive response. By upregulating Mn-SOD without commensurate increase in catalase activities, an imbalance in oxidant processing occurs. This …
-
Automated classification of malignant melanoma based on detection of atypical pigment network in dermoscopy images of skin lesions
“Melanoma causes more deaths than any other form of skin cancer. Early melanoma detection is important to prevent progression to a more deadly stage. Automated computer-based identification of melanoma from dermoscopic images of skin lesions is the most efficient method in early diagnosis. An …
-
Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
-
Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
-
Evaluation of Anti-cancer effect of a Novel Formulation from Umbilical Cord Blood Stem CellDerived Exosomes and Retinoic acid as a potential therapeutic candidate against Malignant Melanoma
… on lymphocytes from healthy individuals and melanoma patients and on the CHL-1 and FM55 melanoma cell lines. The optimal doses were identified as 10 µM for RA and 120 µl of 107 particles/ml for CBSC-derived exosomes. Both doses significantly exerted cytotoxic and genotoxic effects on FM55 and …
-
Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure
… properties and changes to them by using a malignant melanoma cell line (WM1158) and a chemoresistant malignant melanoma cell line (SK-MEL29). Malignant melanoma was the cell line of choice as it is one of the most prominent types of cancer known to develop chemoresistance. The aim of this …
-
Η συμβολή της ραδιοανοσολογικής μεθόδου στη μελέτη της φαρμακοκινητικής της ιντερφερόνης σε ασθενείς με νεοπλάσματα
… diseases and among them for the management of malignant melanoma. Considering the extremely high cost of this product and the existing relationship between the therapeutical results and the levels of the drug in the serum, the individualization of dose becomes a necessity. The pharmacokinetics …
Page 1 of 4