Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Malignant Glioma"”.
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Malignant Glioma: Chemosensitivity testing and Biomarkers
… during the management of several types of malignant tumours in routine clinical practice. The present work attempts to transfer the use of these two concepts to the management of malignant gliomas. Chemosensitivity testing was performed on twelve primary malignant glioma cultures at passage …
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Mesenchymal stromal cells in malignant glioma - Functions and therapeutic potential
The most common malignant brain tumor in adults is a glioma called glioblastoma multiforme (GBM). About 300 persons are diagnosed with GBM every year in Sweden. Unfortunately, it is also the most aggressive brain tumor and as of today, it is not possible to cure it. Despite treating the patients …
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The Expression and Function of Wilms' Tumor 1 in Malignant Glioma
… anti-cancer therapies. In vitro studies in non-glioma cells types have demonstrated that WTl plays a role in increased proliferation, resistance to apoptosis, and increased cellular invasion. We aimed to thoroughly characterize the expression pattern of Wilms' tumor 1 in human malignant glioma …
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Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors
<p>Introduction: Malignant glioma display a highly glycolytic phenotype where the tumors flux glucose to lactic acid independent of oxygen concentration ("aerobic glycolysis"). This altered phenotype is facilitated by expression of primarily fetal enzyme isoforms in these malignant tumors. The …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… of central nervous system (CNS) tumors such as malignant glioma have only been modest. One particular challenge facing treatment of brain tumors is the delivery of therapeutically effective concentrations of anti-cancer agents to the target site in the brain. The sanctuary of the brain is …
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Mechanistic study on the therapeutic strategy to enhance glioma cell death through inhibition of proteasome and lysosome
Malignant gliomas, the most common brain tumors with high mortality, remain largely incurable despite multimodal treatments including surgical resection, radiotherapy, and chemotherapy. Thus, the researchers are currently attempting to develop novel therapeutic strategies for malignant gliomas. …
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IDENTIFICATION OF HCMV UL97 IN GBM CELL LINES AND A POSSIBLE ROLE FOR GANCICLOVIR
… multiforme (GBM) is the most common form of malignant glioma, comprising 80% of all malignant gliomas. Recently, active Human Cytomegalovirus (HCMV) was identified in GBM cells, and has been a topic of debate concerning its role with tumor progression. This study used three established GBM …
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Metal-cyclam based Metal-Organic Frameworks for CO₂ Chemical Transformations
… and studied as light activated drugs to kill rat malignant glioma F98 cells. Both compounds display strong absorption in visible spectrum, oxygen-mediated DNA and BSA photocleavage and significant photocytotoxicity under blue light irradiation along with negligible activity in the dark. The …
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CHARACTERIZATION OF HCMV-ENCODED CHEMOKINE RECEPTOR US28 TRANSDUCED MSU1.1 HUMAN FIBROBLAST CELLS
… in NIH-3T3 (mouse fibroblast) and U373 (malignant glioma) cell lines. The reported prevalence of US28 in GBM and confirmation of oncomodulation via increased proliferation in MSU1.1 cells makes US28 a potential target warranting further understanding of the virus’ role in GBM.</p>
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Telomerase a prognostic marker an therapeutic target
Malignant glioma is the most common and aggressive form of tumours and is usually refractory to therapy. Telomerase and its altered activity, distinguishing cancer cells, is an attractive molecular target in glioma therapeutics. The aim of this thesis was to silence telomerase at the genetic level …
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Virus-Based Nanoparticles for Tumor Selective Targeting and Oncolysis
… progression of xenotransplanted fibrosarcoma and malignant glioma tumors and provided a survival advantage in nude mice. We also engineered NDV M based particles with nipah virus surface glycorporteins to target ephrin B receptors. NDV based nipah Virus BNPs (NiV-ndBNP) were morphologically …
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Evaluation of the therapeutic potential of red clover extract and red grape seed extract on human adult malignant brain tumours in vitro
Gliomas are rare intrinsic brain tumours which account for 2% of all cancers. Glioblastoma multiforme is the most malignant malignant glioma form and remains incurable. The biological features which preclude successful therapy include heterogeneity, diffuse invasive patterns and angiogenesis. …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… therapeutic approach have been developed for malignant gliomas, these can not save the patients from the tumors due to infiltrating behavior of these glioma cells. Here, author investigated the possibility of treatment for the malignant gliomas with neural stem cell (HB1.F3) transduced with …
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Selective targeting to glioma with nucleic acid aptamers
The term glioma encompasses brain tumours arising from the glial cells. Malignant glioma are characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue, hence diagnosis and treatment is difficult, and patient survival is poor. Aptamers are small …
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Malignant Gliomas Originate From Neural Stem/Progenitor Cells and Are Maintained By Cancer Stem Cells
Malignant glioma is one of the most aggressive cancers. To study the biology of glioma, our lab previously developed a series of mouse models that phenocopy both tumor initiation and progression through stochastic tumor suppressor loss-of-heterozygosity (LOH). To determine whether the mouse models …
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Effect of Interstitial Fluid Flow and Radiotherapy on Glioblastoma Invasiveness and Progression
Glioblastoma (GBM) is the most aggressive and malignant glioma. It accounts for 48.6% of all primary, malignant gliomas with a median survival of 15 months. Infiltration into the surrounding parenchyma is a hallmark of GBM. Radiotherapy is used to address the invasion; however, recent studies have …
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Nanoemulsion formulations for brain tumour therapy
Patients with malignant glioma have poor prognosis in spite of the advances in cancer therapy. Only 15% of the glioma patients survive more than five years after diagnosis. This is because the drug cannot reach the tumour site in sufficient amounts. The aim of this project is to investigate the …
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Stem cell based therapy of malignant brain tumors
Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. The aims of the present thesis have been to develop and explore a stem cell …
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Characterizing and targeting the genomic consequences of ATRX deficiency in glioma
… molecular feature in several cancers, including malignant glioma. As standard of care only leads to transient responses and poor outcomes, there is an unmet clinical need for developing new therapies that target ATRX-deficient glioma. Loss of ATRX gives rise to abnormal G-quadruplex DNA secondary …
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