Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Malignant Brain Tumors"”.
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Stem cell based therapy of malignant brain tumors
Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. The aims of the present thesis have been to develop and explore a stem cell …
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Immunotherapy against malignant brain tumors - of mice and men
… is the most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance towards these treatments. …
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Combined chemotherapy and immunotherapy against experimental malignant brain tumors
… (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic …
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Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
<p>Glioblastoma is the most common and aggressive malignant brain tumor among all primary brain and central nervous system (CNS) tumors. The median survival time for glioblastoma patients given the current standard of care treatment (surgery, radiation, and chemotherapy) is less than 15 months. …
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
Malignant brain tumors such as gliomas can arise from a subpopulation of cells frequently called glioma stem cells (GSCs). These cells are often resistant to conventional therapies, hence are the likely culprits of tumor recurrence. Here, we describe the derivation of a human GSC line, NNI-8. Our …
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Enhanced Delivery of Gold Nanoparticles with Therapeutic Potential for Targeting Human Brain Tumors
The blood brain barrier (BBB) remains a major challenge to the advancement and application of systemic anti-cancer therapeutics into the central nervous system. The structural and physiological delivery constraints of the BBB significantly limit the effectiveness of conventional chemotherapy, …
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Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas
Malignant brain tumors are among the deadliest of human cancers. Despit recent advancements in conventional therapies, glioblastomas remain incurable, largel y due to their ability to invade surrounding tissue. Matrix metalloproteinases are thought to contribute to the invaseive phenotype of human …
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Characterization of Bioreducible Poly(B-amino Ester) Nanoparticles for siRNA Delivery
… multiforme (GBM) is one of the most malignant brain tumors affecting adults. It is characterized by necrotic tissue and abnormal vasculature, making it highly resistant to current cancer treatments. A promising alternative to standard cancer therapeutics is the use of drug delivery …
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A nested case-control study of lung cancer and central nervous system neoplasms among chemical workers
… (OR = 2.4; 95% CI = 1.1-5.2). Elevated ORs for malignant brain tumors were found for employment during the 1960s in the azo dyes area (OR = $\infty;$ 95% CI = 1.1-$\infty)$ and in a building where AQ intermediates were produced (OR = $\infty;$ 95% CI = 0.8-$\infty).$ There also was a suggestion …
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Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression
Brain and other central nervous system cancers affect tens of thousands of people every year and remain a challenging class of diseases to treat. Glioblastoma (GBM) is the most common primary malignant form of brain cancer and accounts for nearly 50% of all malignant brain tumors. Prognosis for GBM …
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Maximizing Local Access to Therapeutic Deliveries in Glioblastoma: Evaluating the utility and mechanisms of potential adverse events for minimally invasive diagnostic two novel therapeutic techniques for brain tumors
Glioblastoma (GBM) is the most common adult malignant glioma (MG) variant, and the median survival of persons with GBM is about 2 years, even with aggressive treatments. Dogs and humans are the only species in which brain tumors commonly develop spontaneously, with an estimated post-mortem …
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Vaccinia Virus-Mediated Glioma Gene Therapy Using p53, IL-2 and IL-12
<p>Malignant brain tumors are generally lethal soon after their diagnosis, and the five-year survival rate for the patient is low in spite of neurosurgery, radiation therapy, and/or chemotherapy. Gene therapy has the potential to improve patient survival and quality of life by delivering specific …
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Characterization of Metallic Flavor in Drinking Water: An Interdisciplinary Exploration through Sensory Science, Medicine, Health, and the Environment
… on chemosensory functions of patients with malignant brain tumors undergoing combined modality treatment (CMT) was explored. The results indicated that chemosensory dysfunctions of the patients can range from minimal to moderate impairment with maximum impairment developing during the 6-week …
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Preclinical Study of Potential Antiglioma Novel Tetrahydroisoquinoline Analogs: Pharmacokinetics and Mechanism of Action
<p>Gliomas, the tumors of glial cells, account for 80% of primary malignant brain tumors. In 2011, there were about 18,300 new cases of maligant gliomas in the United States alone. Patients with glioblastoma multiforme or anaplastic astrocytoma, the two major types of malignant gliomas, have a …
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Exploring Interactions Between Malignant Brain Cancer Cells and the Tumor Microenvironment Following High-Frequency Irreversible Electroporation
… high-frequency pulsed electric fields to tumors, triggering the formation of irreversible membrane pores and to induce tumor cell death. H-FIRE has demonstrated pre-clinical and clinical utility as a therapeutic for brain tumors, including gliomas. H-FIRE has been shown to induce precise, …