Global ETD Search
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Showing 1 to 20 of 103 for “"Malaria parasite"”.
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Drug discovery against malaria parasite: drug repositioning strategy
Malaria, caused by Plasmodium spp., causes ~1 million deaths each year and there are ever present problems due to drug resistance. In this work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, …
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Engineered tools for studying the malaria parasite plasmodium falciparum
… techniques to both prevent and treat the disease malaria are necessary. To develop these novel strategies, innovative tools must be designed to study the basic biology within Plasmodium falciparum and characteristics of the pathological relationship between host and parasite. These tools will be …
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Exploring Kinases of Metabolism and Signaling in the Malaria Parasite Plasmodium
<p>Plasmodium is the causal agent of malaria, which is a parasitic disease that affects more than 215 million people annually and is endemic in 91 countries worldwide. Unfortunately, the parasites have developed resistance to all current pharmaceuticals used to treat malaria, including the …
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Human host and malaria parasite genome variations to susceptibility to malaria
… genetic variants affecting drug metabolism. Antimalarial drugs are used in populations carrying different profiles of genetic variability. However, there is limited information on the distribution of genetic variants of pharmacogenomics importance in African populations. Aims: We set out to …
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The interaction of verapamil with the human malaria parasite : Plasmodium falciparum
Includes bibliographical references (leaves [129]-144).
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The Unconventional Amino Acid Starvation Response of the Malaria Parasite, Plasmodium falciparum
The apicomplexan parasite, Plasmodium falciparum, is the causative agent of the most severe form of malaria, resulting in nearly 1 million deaths each year. The parasite establishes its replicative niche within human erythrocytes, where it degrades massive amounts of host cell hemoglobin, salvaging …
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Towards the development of an RT-PCR protocol for malaria parasite genes
Malaria is a life-threatening parasitic disease, which is becoming increasingly problematic in Sub-Saharan Africa due to the spread of drug-resistant parasite strains. Novel therapeutic targets and drugs are thus required to successfully treat and/or prevent malaria. The aim of this study was the …
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Proteome-wide Functional Profiling of Serine Hydrolases in the Human Malaria Parasite
… and prokaryotes. The most virulent human malaria parasite Plasmodium falciparum has over 40 predicted serine hydrolases (SH). Prior investigation on a few of these have suggested their critical role in parasite biology. The majority of the SHs in P. falciparum have not been functionally …
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Characterization of a glycerophosphodiester phosphodiesterase in the human malaria parasite Plasmodium falciparum
… for the intra-erythrocytic development of the malaria parasite, Plasmodium falciparum. Enzymes that hydrolyze host-derived lipids play key roles in parasite growth, virulence, differentiation, cell-signaling and hemozoin formation. Therefore, investigating enzymes involved in lipid degradation …
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Purification and Characterization of Soluble Antigens From the Human Malaria Parasite, Plasmodium Falciparum
… is one of four species of protozoa that cause malaria in humans. It is the most lethal and studies on the immune response to malaria and the development of effective vaccines are crucial.
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Identification of malaria parasite-infected red blood cell aptamers by inertial microfluidics SELEX
Malaria kills over 500,000 people annually, the majority of whom are children under five years old in sub-Saharan Africa. This disease is caused by several parasite species, of which Plasmodium falciparum is associated with the highest mortality. The clinical manifestations of malaria are …
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Engineering control of eukaryotic translation with application to the malaria parasite Plasmodium falciparum
… level. Plasmodium falciparum, the protozoan parasite responsible for the majority of death and sickness due to malaria, remains challenging to manipulate in the laboratory. No robust and generalizable tool for gene expression control has been developed in the parasite. To address this need, …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
*Plasmodium falciparum* is a parasite that causes the most severe forms of human malaria; with multidrug resistance to modern antimalarials emerging and spreading in certain parasite populations, understanding the mechanisms for acquiring multidrug resistance will be key for predicting which genes …
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In silico prediction of host-pathogen protein - protein interactions in the malaria parasite, Plasmodium falciparum
Malaria claims millions of lives annually. This global killer causes approximately 2.7 million annual deaths worldwide; addressing this problem has become more and more crucial. Due to pathogen evolution no efficient vaccine for treatment of malaria currently exists. As infection has developed as a …
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Using biophysical tools to explore the erythrocyte preferences of the zoonotic malaria parasite Plasmodium knowlesi
Malaria is a parasitic infectious disease, which is caused by parasites of the *Plasmodium* genus which are transmitted to vertebrate hosts by mosquito bite. Despite major intervention and control efforts, malaria is still responsible for almost half a million deaths every year, primarily in …
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Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes
In 2017 malaria cases were estimated at 219 million and of these 435 000 resulted in death. Malaria is transmitted by female Anopheles mosquitoes which thrive in tropical and sub-tropical areas. Malaria is caused by five species from the genus Plasmodium, namely P. falciparum, P. vivax, P. ovale, …
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Exploration of the malaria parasite lifecycle stages and strains circulating in natural infections at single-cell resolution
Malaria is still a major global public health problem, resulting in an unacceptably high annual mortality of over half million. Extensive diversity in malaria parasites is a key challenge in developing effective interventions. Many infections constitute several strains, and this complicates malaria …
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Probing the chemical biology involved in the haem detoxification pathway of the human malaria parasite, plasmodium falciparum
… the infectious agent responsible for most malaria-related deaths in humans, is the haem detoxification pathway. P. falciparum parasites in the asexual blood stage take up haemoglobin from the red blood cell (RBC) cytosol to make space for its growth and to prevent premature RBC lysis by …
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