Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Malaria infection"”.
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Hybrid multi-scale mathematical modelling of malaria infection transmission
See the attached abstract below
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
Malaria killed an estimated of 437,000 people last year, most of them children. While there is a vaccine nearly licensed, it only induces limited and short-lived protection. A major problem in the development of an effective vaccine is the poor understanding of the mechanisms that generate …
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Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
Severe malaria infections cause almost 1 million deaths annually, mostly among non-immune African children. The pathogenesis of severe malaria is poorly understood. It is increasingly appreciated that while host innate immune responses such as inflammation and phagocytosis are critical for control …
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Prevalence and impact of Malaria infection on pregnancy and prenatal outcomes in the Blue Nile state of Sudan
Malaria is a global public health concern. It is prevalent in the Blue Nile state of Sudan, where the incidence rate exceeds 34%, according to a 2015 survey. P.falciparum is the dominant infecting species in sub-Saharan Africa; it particularly affects pregnant women, for it tends to sequester in …
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Indirect Maternal Mortality Due to Malaria: A Systematic Review and Meta-Analysis
Background: Malaria is a major contributor to indirect maternal mortality in endemic regions. However, the magnitude of the effect of pregnancy on malaria-associated mortality and the role of malaria infection in maternal mortality remain uncertain. This study aimed to review the evidence and …
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Linking Environmental Factors To Vector Abundance And Malaria Incidence: A Multi-Model Investigation Of Disease Ecology.
… climatic, and entomological factors influencing malaria transmission in Mozambique. Malaria remains a leading cause of morbidity and mortality across the country, where transmission dynamics are shaped by ecological heterogeneity, vector behavior, and changing environmental conditions. By …
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Molecular cloning and expression in Escherichia coli of a malaria exoantigen from Plasmodium falciparum, putative candidate for vaccine
Malaria remains as one of the biggest public health problems in the world today. Plasmodium falciparum is the most lethal among the four species of protozoa that cause malaria infection in humans. In the parasite life cycle the asexual blood stage is responsible for the clinical manifestations of …
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Application of microfluidic device to malaria diagnosis
… and sensitivity. The application of diagnosis of malaria infection by microfluidics is studied. Malaria infected red blood cells will cause a cell stiffening, and the different behaviors of iRBCs could be detected by microfluidics. The malaria market and various business model is analyzed, and a …
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Malaria immunology and vaccine development
… It<br/>begins by providing an introduction to malaria infection and pathophysiology, and<br/>a review of the latest attempts to produce an effective malaria vaccine. It goes on<br/>to describe the rationale behind the vaccines developed by the University of<br/>Oxford and others. A brief …
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Engineering human hepatic tissue for modeling liver-stage malaria
… an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, targeting the liver stage has been difficult due to a lack of human liver models that robustly recapitulate …
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The occurence, distribution and frequency of membrane transporter resistance alleles in <i>Plasmodium falciparum</i> and their association with response and resistance to Arteminisin based combination therapy (ART) in Northern Nigeria
Malaria infection is caused by, <i>Plasmodium falciparum</i> (<i>P. falciparum</i>) parasite. It is the most significant cause of high morbidity and mortality rate in humans. This has created an enormous social and economic burden in many endemic regions in the world. Disturbingly, <i>P. …
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The Development and Application of Coupled Multiscale Models of Malaria Disease System
… models of direct vectorborne diseases using malaria as a paradigm. We have developed a basic coupled multi-scale model with a combination of two other categories of multi-scale models, which are a nested multi-scale model in the human host and an embedded multi-scale model in the mosquito …
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Prothonotary Warbler (Protonotaria citrea) Plumage as an Indicator for Infection: the Relationship between Haemosporidia Infection and Breast Feather Reflectance in a Neotropical Migrant Passerine
… between Haemosporidia (pathogen causing Avian Malaria) infection and feather reflectance (n=41). Reflectance was characterized using a Principle Component Analysis evaluating Intensity, Brightness, Hue, UV Intensity, UV Brightness, and UV Chroma. UV and visible light reflectance was higher in …
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Soluble expression of plasmodium falciparum glutamine synthetase and three-dimensional structure by single particle reconstruction
[No subject] Malaria infection caused by the apicomplexa pathogen Plasmodium falciparum has a high rate of resistance to existing anti-malarial drugs. The World Health Organisation recommended interventions are unlikely to eliminate the growth of resistance and it would therefore be prudent to …
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A Multi-level Model for a Vector-Borne Organ to Tissue life Cycle Dynamics
Introduction: Malaria is among the World’s most lethal infectious disease. It is caused by a parasitic pathogen transmitted by the Anopheles mosquito, which inoculates sporozoites into the human host during a blood meal. The population dynamics of malaria are well-known for their complexity, …
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Biophysical properties of blood-stage Plasmodium falciparum malaria: from single-cell host-pathogen interactions to human protective polymorphisms
Malaria is a mosquito-borne infectious disease responsible for half a million deaths every year and long-term economic stagnation in many countries where it is endemic. All symptoms and pathology of malaria are caused by Plasmodium falciparum parasite, and are initiated when parasites invade human …
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The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice
… poor efficacy has been attributed in part to coinfections with many other unrelated pathogens that overlap geographically with Mycobacterium tuberculosis (M. tuberculosis). In this study, we used a murine model to investigate the effect of Plasmodium species virulence and the timing of infection …
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Gene expression profiling approach towards enhancement of malaria vaccine development
Malaria continues to be one of the highest morbidity and mortality infectious diseases in the world, posing an enormous public health burden with significant economic consequences. The development of vaccines that provide sterile protection against pathogenic infection by the Plasmodium parasites …
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Investigating the role of CD56⁻ ‘atypical’ NK cells in Gambian children with asymptomatic malaria
Malaria is a parasitic disease responsible for over 600,000 deaths a year, caused by Plasmodium parasites. In malaria-endemic regions, individuals endure repeated exposure to and are infected with the parasite throughout their lives. Despite this high exposure level, complete parasitic clearance …
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