Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Makrophagen-Inhibitionsfaktor"”.
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Molekulare Steuerung des Mamma-Karzinom-Verhaltens durch das inflammatorische Zytokin MIF
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine and mediator of acute and chronic inflammatory diseases. MIF is overexpressed in various tumours and has been suggested as a molecular link between chronic inflammation and cancer. In the context of the present study we …
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A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
Parasitic organisms have evolved specialized strategies to evade host immune defense mechanisms. This thesis describes the characterization of two Leishmania major-encoded orthologs of the pro-inflammatory pleiotropic cytokine, macrophage migration inhibitory factor (MIF). These two MIF-like …
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Identification of novel chemokine and chemokine-like mechanisms in leukocyte adhesion and atherosclerotic lesion formation
This study surveys the expression control and the down-stream effects of two mediators that have a severe impact on atherosclerosis progression. The first approach identified YB-1 as a new transcriptional regulator of the CC chemokine RANTES. RANTES is upregulated in mononuclear cells or deposited …
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Molecular mechanisms of the unconventional secretion of macrophage migration inhibitory factor (MIF)
Macrophage migration inhibitory factor is a pro-inflammatory cytokine that plays a pivotal role in the pathogenesis of inflammatory disease such as septic shock and rheumatoid arthritis. The release of MIF from inflammatory cells is a common feature in these diseases, and a correlation between the …