Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Major trauma"”.
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Immune biomarkers predicting clinical outcomes for major trauma patients
Major trauma continues to be the most common cause of death in the population under the age of 40 in England. Despite advances in trauma care in the UK, sepsis and multiple organ dysfunction syndrome (MODS) continue to be severe complications of trauma worldwide. Ongoing research exploring the …
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Immune biomarkers of clinical outcome in patients with major trauma
Major trauma currently accounts for 10% of deaths globally. Although the implementation of standardised protocols for the management of poly-trauma has resulted in significant improvements in early-phase trauma care, sepsis and multiple organ dysfunction syndrome remain challenging complications …
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Understanding and ameliorating perturbations of human cerebral energy metabolism after major trauma
After sustaining a severe traumatic brain injury (TBI) dysfunction of cerebral energy metabolism can cause further injury to the traumatised brain – resulting in worse patient morbidity, or death. Using the modalities of cerebral microdialysis, 13C labelled high-resolution nuclear magnetic …
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Major Trauma Outcomes: At What Cost? And for Whom? A Cost-Effectiveness Analysis
… (a) to identify the financial costs for acute trauma care, including costs for those who die early in treatment, and who pays those costs; (b) to identify the relationship between costs and severity of injury; and (c) to identify survivor functional and psychosocial costs, or quality of life, …
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Investigating cytokine biomarkers as early predictors of poor clinical outcome following major trauma
Despite recent advances in critical care, trauma still continues to be the leading cause ofmorbidity and mortality among individuals under 40 years of age and the third main cause ofdeath throughout the world, carrying a substantial economic burden. Globally, the mostcommon traumatic injuries are …
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Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma
Trauma is a leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is falling from less than 2 meters, with the primary …
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Relationship between prehospital time and 24-hour mortality following injury in patients with major trauma in New Zealand
… mortality following injury in patients with major trauma in New Zealand (NZ). Methods: Following a systematic review to describe the incidence and characteristics of major trauma in NZ, analysis of routinely collected data from a retrospectively designed prospective cohort study was …
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The availability of acute care resources to treat major trauma in different income settings: a self-reported survey of acute care providers
… compare the availability of resources to manage major trauma between high income, and low- to middle-income countries, as self-reported by delegates at the 2016 International Conference on Emergency Medicine held in Cape Town, South Africa. Materials and methods: A survey was distributed to …
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Experience with the Treatment of Patients with Major Trauma at the Department of Trauma Surgery in One Regional Emergency Medical Center for One Year
… Recently, social interest in an organized trauma system for the treatment of patients has been increasing in government and academia and the establishment of trauma center is being considered across the country. However, establishing such a system has not been easy in Korea, because …
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Widened mediastinum on chest radiography as a prompt for further imaging in suspected blunt traumatic aortic injury: 3-year experience at a major trauma centre
Background: Trauma clinicians utilise the presence of a widened mediastinum on a chest radiograph (CXR) as the commonest indication for chest computed tomography (CT) in cases of suspected blunt traumatic aortic injury (BTAI). Evaluating the practical implementation and accuracy of this tool could …
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A descriptive study of trauma patients transported by the KZN Helicopter Emergency Medical Services to the Durban Inkosi Albert Luthuli Central Hospital level one Trauma centre over a three - year period
… and time to definitive treatment is key in trauma care. Helicopter Emergency Medical Service (HEMS) is an invaluable prehospital asset for the transport of time sensitive trauma. This study reviews the impact of HEMS in the management of trauma at Inkosi Albert Luthuli hospital (IALCH) which …
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Exploring recovery and rehabilitation experiences of adults with major and moderate non-neurological traumatic injuries in the north of Scotland.
Traumatic injuries can have a significant impact on individuals' short-term and long-term health outcomes. The introduction of trauma networks internationally has improved the survival of individuals with severe physical injuries. With more individuals surviving traumatic injuries, the focus of …
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Re-examining typologies of sexually violent offenders
… of restraints, 4) infliction of unusual assault/trauma, 5) type of sexual activity, 6) major trauma location, and 7) use of a weapon. After considering univariate entropy results for the initial variables, use of restraints, certain types of sexual activity, and use of a weapon were eliminated …
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PTSD symptom clusters : the relationship with types of traumas and cognitive ability
Experiencing a major trauma can lead to psychological symptoms known as PTSD. Even though the prevalence of experiencing traumatic events is considered as high as70%, subsequently developing PTSD has been found to be lower than 10%. To understand this relationship studies have focused on various …
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THE MANAGEMENT OF TEMPORARY STAFF IN HEALTHCARE EMERGENCY DEPARTMENTS : IMPLICATIONS FOR PATIENT SAFETY AND SERVICE QUALITY
… second studied the management of the launch of a Major Trauma Centre introducing a Consultant Resident On-Call for trauma, which required temporary contracts. The research was conducted through case studies utilising semi-structured interviews. The ED was specifically chosen because of its high …
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The effectiveness of airway management in the pre hospital treatment of traumatic brain injury : a retrospective, observational study of pre hospital treatment of traumatic brain injury (TBI) in the Western Australian ambulance service
… in the pre hospital treatment of patients with Traumatic Brain Injury is controversial. Currently in St John Ambulance Service Australia (WA) Inc. three forms of pre hospital treatment are utilized to manage the airway of the adult head-injured patient. If attended by on-road paramedic staff, …
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Determining Structural Transitions That Occur Upon Gating a Bacterial Mechanosensitive Channel
… in osmotic environment which can result in major trauma to the cell. The mechanosensitive channel of large conductance (MscL) is one of a handful of channels that responds to tension in the membrane and acts as a lifesaving mechanism for the cell in instances of osmotic down shock. Solutes …
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Opioid use, dependence and complications following musculoskeletal trauma and surgery
… opioid use and dependence within an orthopaedic trauma and end-stage osteoarthritis population and to test a new model (a less-is-more-approach) for pain management after fracture surgery. Specifically, six studies were undertaken including five cohort studies and a single randomised trial. Main …
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Technology-Driven Solutions for Smarter Care: Telemedicine, Data-Driven Analytics, and AI in Healthcare Operations
… uncertainty is moderate. Part II turns to trauma care in the East of England. Using nine years of data from the regional trauma network, this empirical study evaluates rising trauma demand, geographic disparities in access to Major Trauma Centres (MTCs), and the performance of Trauma Units …
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The Transcriptional Profile of Microglia: From Brain to Dish
… and in-vitro model systems to answer three major questions: 1. Can transcriptional data from fresh, primary human microglia be used to identify novel subpopulations of cells and understand how clinical phenotypes influence gene expression? 2. How accurately do current simple in-vitro model …
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