Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"Major histocompatibility complex (MHC)"”.
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
The essential role of classical MHC molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of nonclassical MHC molecules, the signals evoked by the MHC-TCR interactions, the …
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MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) VS NON-MHC INFLUENCES ON RESPONSE TO RSV-INDUCED TUMORS IN CHICKENS
<p>The MHC of the chicken (B complex) has been shown to exert a decisive influence on the fate of Rous sarcoma virus (RSV)-induced tumors. However, noninbred chickens with identical B genotypes and inbred lines indistinguishable at the MHC have demonstrated considerable variation in response to RSV …
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Does variability matter? Major histocompatibility complex (MHC) variation and its associations to parasitism in natural small mammal populations
… Variability at immune genes, such as the major histocompatibility complex (MHC) genes, is assumed to be a very powerful and effective tool to keep pace with diverse and rapidly evolving pathogens. In my thesis, I studied natural levels of variation at the MHC genes, which have a key role …
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Immunological Response to Clostridium perfringens in Two Genetically Divergent Lines of Chickens as Influenced by Major Histocompatibility Complex (MHC) Genotype
… cells (SRBC) displayed a correlated change in major histocompatibility complex (MHC), so that LA chickens were 96% B¹³ and HA chickens were 96% B²¹. During a clinical outbreak of necrotic enteritis, B²¹B²¹ genotypes experienced significantly less mortality (6% vs. 13 %) compared to B¹³B¹³ …
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The development of the single-strand conformation polymorphism (SSCP) technique to assess sequence level variation within the major histocompatibility complex (MHC) DRB1 gene in four South African buffalo (Syncerus caffer) populations
… to assess sequence level variation within the Major Histocompatibility Complex (MHC) DRB1 gene in four South African buffalo populations. MHC gene products are involved in the immune response, and so variation within these genes provides information on the immunological fitness of the …
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T-cell receptor diversity of various antigen-specific T cells
… bound to a membrane-bound protein coded by the major histocompatibility complex (MHC) locus. Like immunoglobulins, the TCR repertoire is diverse because both the $\alpha$ and $\beta$ chains are coded by multiple genes that undergo rearrangement. The general goal of this study was to determine …
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Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
… along with alleviating hippocampal IL-1beta and major histocompatibility complex (MHC) class II mRNA expression in aged mice. Collectively, these studies showed that luteolin might be a promising agent for preventing neuroinflammation and neuronal cell death mediated by activated microglia and …
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Characterization of a T cell receptor and its ligands
… antigens associated with class I major histocompatibility complex proteins. Recognition occurs between the T cell receptor (TCR) and a complex of an antigenic peptide/major histocompatibility complex (MHC) product. In addition, the CD8 molecule of the CTL stabilizes the interaction …
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Autoimmune Susceptibility Imposed by Public TCRβ Chains
<p>The major histocompatibility complex (MHC) is the strongest genetic risk factor for autoimmunity. It acts together with a corresponding TCR repertoire, yet, considering the extent of the repertoire's diversity, how this imposes disease susceptibility on a population is not well understood. We …
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Narrowing of the SLES1 Internal Reveals Complex Epistatic Interactions in the Suppression of Autoimmunity
… allele-specific and tissue-specific reduction of major histocompatibility complex (MHC) Class II molecules on the surface of B cells, as well as a possible role for follicular helper T cells in the development of Sle1-mediated autoimmunity. Understanding how Sles1 and other modifiers suppress …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
… and ligands, such as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of co-inhibitory molecules are required for …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… transmembrane domains of the beta chain of human major histocompatibility complex (MHC) class II molecule and the cytoplasmic zeta chain of T cell receptor and pairing it to the alpha chain linked to zeta. CD8<sup>+ </sup>receptor-modified T-cells (RMTC) were able to recognize the cognate TCR …
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Insight into the structure and function of empty class II major histocompatibility complexes
Class II major histocompatibility complex (MHC) proteins bind peptides and present them at the cell surface for interaction with CD4+ T cells as part of the system by which the immune system surveys the body for signs of infection. Peptide binding is known to induce conformational changes in class …
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Associations of egg production with the major histocompatibility complex in broiler breeder hens
This study documents effects of the major histocompatibility complex (MHC) on reproductive traits in a flock of Cobb X Cobb broiler breeder hens. The objective was to determine if the MHC affects reproduction of non-congenic broiler breeder hens. Genomic DNA was isolated from 35 hens. Restriction …
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The role of nonclassical MHC class I products in the development and function of CD8+ T cells
Major histocompatibility complex (MHC) class I products present pathogen-derived peptides to CD8+ cytotoxic T cells. This interaction mediates the detection and clearance of intracellular infections. Emphasis has been placed on the critical role of classical class I MHC products in the development …
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The Expression Of Connexin-43 By CD11c+ Dendritic Cells Is Required to Maintain CD4+ Foxp3+ Regulatory T Cell Population in Peripheral Lymphoid Organs
… are sustained by the interaction between the Major Histocompatibility Complex (MHC) molecules present on antigen presenting dendritic cells and the T Cell Receptor (TCR) expressed on T<sub>R</sub> cells that is specific for the MHC loaded with an antigenic peptide. Here, we show that in …
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Substratum Interactions Modulate the Interplay between Endothelial Cell Phenotype, Function, and Immune Recognition
… expression of adhesion molecules, chemokines, major histocompatibility complex (MHC), and an array of co-stimulatory and inhibitor molecules. These interactions allow ECs to act as antigen presenting cells (APCs) and influence the outcome of immune recognition. Thus, the study of ECs elucidates …
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Protective Immunity in Atherosclerosis
… could be provided. Antigen presentation on major histocompatibility complex (MHC) class II is critical in activation of CD4+ T cells whereas CD1d antigen presentation is required for activation of NKT cells. The role of MHC class II antigen presentation in atherosclerosis is complex and was …
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Polymorphism of bovine MHC class II genes: Association with persistent lymphocytosis caused by bovine leukemia virus
Polymorphism of bovine major histocompatibility complex (MHC) class II DQA, DQB, and DRB genes was investigated by sequence comparisons between class II genes of cattle and other species. The association between BoLA-DRB3 alleles and persistent lymphocytosis (PL) caused by bovine leukemia virus …
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