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Showing 1 to 13 of 13 for “"Magnetic tweezers"”.
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Developing Magnetic Tweezers for Magnetic Material Manipulation
… materials. Among current available methods, the magnetic tweezers show high efficiency and cost effectiveness in generating strong and direction adjustable interactions with magnetic materials. Since our research group has extensive experience in synthesizing magnetic nanostructures, it is of …
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Single Molecule Force Extension Measurement on Semi-Flexible Biopolymers Using Magnetic Tweezers
… DNA. Single DNA molecules are studied using magnetic tweezers and an inverted fluorescence microscope. Magnetic forces in the piconewton range are applied to individual DNA molecules, and the relative chain extension due to applied force is directly measured and shown to be between 15% and …
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SINGLE-MOLECULE STUDY OF THE FORCE-INDUCED ACTIN POLYMERIZATION MEDIATED BY FORMIN
… MANIPULATION TOOLS: HYDRODYNAMIC FLOW, OPTICAL TWEEZERS AND MAGNETIC TWEEZERS. USING HYDRODYNAMIC FLOW, SINGLE ACTIN FILAMENTS CAN BE STRETCHED IN HIGH-THROUGHPUT. HOWEVER, THOUGH THERE MAY BE SOME WEAK DECREASE OF CRITICAL CONCENTRATION BY FORCE, ITS LOW SENSITIVITY LIMITED THE DRAWING OF …
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On the Rheology of Soft Cellular Materials, An Experimental Investigation of the Microstructure and Rheology of a Novel Tissue-Mimic Material
… describes a rheometer developed for the purpose; magnetic tweezers with an integrated thermostatic water bath, capable of conducting creep tests on samples of vesicle aggregate material over a range of temperatures. This strand also presents discussions on the calibration of magnetic tweezers, and …
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Quantitative biological studies at cellular and sub-cellular level
We developed a translational magnetic tweezers for quantitative measurements at cellular and sub-cellular level. In the cellular studies, multiple membrane tethers were extracted simultaneously under constant force transduced to eukaryotic cells through magnetic beads attached to their membranes. …
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EFFECT OF MISMATCHED BASE PAIRS ON DNA PLECTONEMES
… localization could make pinning unfavorable. Magnetic-tweezers-based studies of DNA supercoiling, performed at high salt concentrations, have shown that in DNA harboring a single mismatch, the plectoneme will always localize at the mismatch. Theoretical studies have predicted that under …
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Biological Adhesion on Nanopatterned Substrates Studied with Force Spectroscopy and Microinterferometry
… was studied at different timescales using magnetic tweezers and atomic force microscopy (AFM). The experiments demonstrated that an integrin binding site spacing of 70 nm and more prevents the cooperative formation of early adhesion clusters in initial adhesion. In long-term adhesion …
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Cellular responses to mechanical stresses applied via magnetic manipulators
… developed. Atomic force microscopy, optical and magnetic tweezers, micropipette aspiration and other techniques have been used to explore and develop physical models of the cell. By using these techniques, the basic physical response of a cell to mechanical forces has been analyzed, yet the …
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Transport properties of DNA nanostructures
… super-resolution optical imaging, FRET and magnetic tweezers, have been applied to study the global structure and dynamics of the DNA nanostructures. Recently, an atomic-level model of DNA origami in situ has also been obtained, which showed considerable deviation from the idealized …
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Advances in single molecule spectroscopy and microscopy for biological imaging and polymer characterization
… as persistence length and contour length. We use magnetic tweezers for SMFS, a commonly used technique where a paramagnetic bead is attached to a tethered polymer, allowing for an external magnetic field to pull on the polymer. By observing the bead position over time, we can extract information …
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Multivalent Programmable Interactions Between Lipid Vesicles: Towards Responsive Soft Materials
… particles and active microrheology using magnetic tweezers. We observe changes in the structure in response to increased temperature, DNA concentration and aging leading to reduced pore sizes. From a rheological standpoint, we observe strain hardening of the material through repeated creep …
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Bulk and micro-scale rheology of an aging, yield stress fluid, with application to magneto-responsive systems
… suspensions, which can be tuned with an applied magnetic field, have been used to create active vibration damping systems in such diverse applications as seismic vibration control and prosthetics. A material that undergoes rheological aging and that has received much attention from soft matter …
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Characterisation of Local Mechanical Properties in Living Tissues
… of tissues remains unknown. Four-pole electromagnetic tweezers have been developed to probe the mechanical properties of living embryonic tissues that are undergoing active morphogenetic development. The device is capable of generating magnetic forces in the order of nano-Newtons on a grafted …