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Showing 1 to 9 of 9 for “"MafA"”.
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Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
… of transcription factors. Two of these factors, MafA and MafB, have been shown to play a major role in the regulation of several genes critical to pancreas development and endocrine cell formation. MafB is essential for both α- and β-cell differentiation, as mice lacking MafB have fewer insulin+ …
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Regulation of Insulin and CHOP Gene Expression in Pancreatic Beta Cells
… gene promoter, I focused on the effect of MafA modification on insulin expression. MafA is a transcriptional activator of the insulin gene via binding to the RIPE3b/C1 (rat insulin promoter element 3b) element. Mutagenesis showed that MafA was post-translationally modified by SUMO-1/2 …
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An investigation of the role of the primary school principal in managing diversity
… managing diversity in Umbumbulu Circuit in the Mafa, Amanzimtoti and Umbumbulu Central Wards. In carrying out this project, the researcher also reviewed relevant literature on policies that provide for the implementation and management of diversity and strategies for optimising the use of …
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Species limits in the Rhodocoma gigantea (Kunth) Linder complex
Rhodocoma gigantea and Rhodocoma foliosus have been recognised by earlier authors as separate species on the basis of perianth length and shape. Linder (1985) superficially lumped these two species under Rhodocoma gigantea arguing that the difference between the two appear to be brought by …
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Response of Cynodon dactylon (L.) Pers. to ammonium and nitrate nutrition
Plants that come early in succession predominantly prefer_ ammonium form of nitrogen than nitrate. The hypothesis that Cynodon dactylon (L.) Pers., a grass in the primary succession stage would respond well when supplied with ammonium than nitrate fertiliser was tested. Seedlings of Cynodon …
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Phylogenetic relationships of the African species of the genus Merxmuellera Conert (Poaceae: Danthonioideae)
This study expands on existing molecular (rpoC2 and ITS) and morphological data sets to further test the hypothesis of non-monophyly of Merxmuellera sensu lato. The results reveal that despite high levels of resolution, the morphological data yield poorly supported phylogenies due to high levels of …
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Role of PARK2Gene in Maintenance of Pancreatic Beta Cell Functions
… secretion. The mRNA levels of the genes Pdx1, Mafa, Mafb, Nkx2-2, Nkx6-1, Pax4, and Irs1 that encode the pancreatic transcription factors were significantly decreased in the Park2-depleted INS-1 β-cells. In addition, the INS-1 β-cells lacking parkin exhibited decreased intracellular ATP level …
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of …