Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Macula"”.
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Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
… (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce acetonide (FA) and triamcinolone (T1) were encapsulated with a combination of nonionic surfactant hydrogenated castor oil (HCO) and octoxynol-40 (Oc-40). A …
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Upregulation of COX-2 protein expression in porcine macula densa with L-NAME treatment
… from enzyme called nitric oxide synthase. Macula densa is a specialized structure in the kidney which co-localizes these two enzymes and is very important in maintaining the renal blood flow. The main goal of this study was to determine how diminished production of nitric oxide, which …
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Evaluating The Estimation of Neuronal Loss in Glaucoma
… layer (RNFL), optic nerve head (ONH) and the macula can be acquired at high resolutions and quantified with excellent repeatability and reproducibility. While OCT morphological measures are clinically used as to represent retinal ganglion cell (RGC) content, the correspondence with RGC content …
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Regulating the bioactivity of placental growth factor in the aging outer retina as a new therapeutic approach to age-related macular degeneration
Age-related macular degeneration (AMD) is a sight-threatening disease caused by degeneration of the macula. Late disease presents as neovascular AMD (NV-AMD) or geographic atrophy (GA). Advances in angiogenesis research have led to the development of treatments for patients with NV-AMD. However, …
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Understanding the genetics and function of complex human retinal phenotypes
… the outer retinal thickness at the central macula compared to the peripheral macula. To further explore the rich dimensionality of OCT data, I developed several image analysis techniques to gain more granular information about the morphological variation being affected by the discovered …
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Cell penetrating peptide for ocular drug delivery
Background and Aim: Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the ageing population of the developed world. Choroidal neovascularisation (CNV), the hallmark of neovascular AMD, results in the loss of sharp central vision due to breakdown of the blood …
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The Development of Flash Visual Evoked Potential Techniques for the Diagnosis of Visual Disorders with Dense Opacities of the Optic Media
… lesions and hemianopia, and a second with senile macula degeneration. The VEP varied with the degree of visual impairment with low amplitudes, long latencies and no localization at either occiput being consistent with poor acuity. The P2 component appeared to be particularly effected by the loss …
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Computer-assisted colour fundus image analysis
… classification. The fovea, which lies within the macula region, is responsible for high resolution vision. Hence, presence of lesions or changes in the morphology of this region may be signs of pathologies such as age-related macular disease, which can cause blindness. Automatic detection of fovea …
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MicroRNA Expression Signature of Retinal Pigmented Epithelial Cells Associated with the Phenotype of Age-Related Macular Degeneration
<p>Age-related macular degeneration is a debilitating condition that manifests as a loss of the central portion of an individual’s field of vision, affecting 1 in 3 people over the age of 80. With regards to the retina, the organ primarily responsible for an individual’s sense of vision, this …
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Visual field and structural alterations in age-related macular degeneration
… 10° visual field with structural changes at the macula in a cross-section of patients with varying degrees of agerelated macular degeneration (AMD). The relationships between structure and function were investigated for both standard and short-wavelength automated perimetry (SWAP). Factors known …
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The actions of gossypol on the physiologic antioxidant defense system
… and ultrastructural changes in endometrial macula adherentes of gossypol treated female rats.
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INTERRELATIONSHIPS BETWEEN MACULAR CAROTENOIDS, RETINAL MORPHOMETRY, AND COGNITIVE FUNCTION IN PERSONS WITH MULTIPLE SCLEROSIS
… regular dietary consumption to derive benefits. Macular xanthophylls are dietary carotenoids that comprise the macular pigment, serving as blue light filters and countering photooxidative damage. The robust antioxidant effects of carotenoids could support nerve health and protect against …
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Diabetic retinopathy among patients attending university teaching hospitals adult hospital medical clinic in Lusaka
… proliferative diabetic retinopathy. Diabetic macula oedema was present in 24 (11.3%; 95% CI 7.5%-16.1%). Duration of diabetes was the most significant (p<0.0001) association found with retinopathy; as well as alcohol intake and having diabetic foot (another microvascular complication). Even …
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Diabetic retinopathy among patients attending university teaching hospitals adult hospital medical clinic in Lusaka
… proliferative diabetic retinopathy. Diabetic macula oedema was present in 24 (11.3%; 95% CI 7.5%-16.1%). Duration of diabetes was the most significant (p<0.0001) association found with retinopathy; as well as alcohol intake and having diabetic foot (another microvascular complication). Even …
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Development of Techniques for Analysis of the Human Retinal Ganglion Cell Transcriptome: Application to the Role of Calcium in RGC Death in Glaucoma
… the retina ganglion cell layer (RGCL) and entire macula (Mac). Immunohistochemistry and QRT-PCR validated gene array data. RGC death was investigated using a simulated ischemia (oxygen glucose deprivation, OGD) model in human organotypic retinal cultures (HORCs). Cell survival was measured by LDH, …
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Deciphering Underlying Mechanisms Of Photoreceptor Outer Segment Degradation; Involvement Of Intracellular Trafficking
Age related macular degeneration (AMD) is the leading cause of vision loss among adults 50 and older in the United States. AMD is characterized by the degeneration of photoreceptors and retinal pigment epithelium (RPE) cells in the macula region of the retina. RPE maintain the health of the retina …
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DOSE RANGING STUDY OF LUTEIN SUPPLEMENTATION IN ELDERLY WITH AND WITHOUT AGE RELATED MACULAR DEGENERATION
Age-related macular degeneration (AMD) is the leading cause of blindness among people over the age of 65. Epidemiological studies have indicated that people with a high intake of two dietary carotenoids, lutein and zeaxanthin that accumulate in the human macula, are at a reduced risk of AMD. …
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Helmintos de populações simpátricas de algumas espécies de anfíbios anuros da família Leptodac tylidae
… Centrorhynchus sp.), L. caliginosus (S. macula, C. parva, Physaloptera sp., Centrorhynchus sp.), L. marmoratus (Neyraplectana sp., C. parva, Physaloptera sp., Centrorhynchus sp.) P. signiferus (O. oxyascaris, A. lopesi, Neyraplectana sp., C. parva, Physaloptera sp., Centrorhynchus sp.) …
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Inner ear morphology in elasmobranchs: implications for auditory capacity and ecology
… end organs (saccule, lagena, utricle, and macula neglecta). Further, there is variation in hair cell organisation between shark species with different feeding strategies, primarily attributed to vertically oriented hair cells. Lastly, using magnetic resonance imaging (MRI) to obtain in situ …
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Stargardt patient experiences in the first gene-based clinical trial for an inherited retinal condition in South Africa
… loss is due to a build-up of lipofuscin in the macula, a part of the retina responsible for sharp central vision. Stargardt disease follows an autosomal recessive inheritance pattern and is currently incurable. This study aimed to explore the expectations and experiences of individuals with …
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