Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Macrophage subsets"”.
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
The interaction between epithelial cells and macrophages is integral to mucosal immune fate: determining the decision between tolerance and immune activation/inflammation. Endotoxin tolerisation (ET) is a circumstance where cells go through a hypo-responsive state, unable to respond to further …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
… CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory (M1) and anti-inflammatory (M2a, M2b, and M2c) subsets. Whether macrophage subset …
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… and anti-inflammatory properties. Gut mucosal macrophage subsets play a fundamental role in driving muco-sal immune responses. These include, tolerance, associated with an M2-, regulatory macrophage phenotype and inflammatory activation with an M1-like phenotype. The cross-link between mucosal …
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Transcriptomic profiling of macrophage polarization
Macrophages perform a wide variety of crucial, and sometimes contradictory, functions. While “pro-inflammatory” activities like fighting off infections and “anti-inflammatory” activities like wound-healing traditionally have been attributed to M1 and M2 macrophage subsets, studies of macrophages in …
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The Expression of the Zinc Finger Transcription Factor zDC Defines the Classical Dendritic Cell Lineage
… by plasmacytoid dendritic cells, monocyte and macrophage subsets, and some lymphocytes. Similarly, the use of the CD11c promoter to drive the expression of different reporters in cDCs likewise affects these additional populations. To identify a novel and more specific cDC marker, I compared the …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the pro-inflammatory M1 and the …
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Role of GPS2 in the regulation and maintenance of adipose tissue physiology and function under metabolic stress and obesity
… progenitor populations, along with immune macrophage subsets, the likes of which collectively contribute to adipose tissue remodeling in response to dietary challenge, and are impacted by the loss of GPS2 in the adipocytes. Insights into the mechanisms of cellular communication that are …
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Probiotic Modulation of Mucosal Immune Responses in an In Vitro Co-Culture Model
… modulation of the gut immune system. Gut mucosal macrophages play a pivotal role in driving mucosal immune responses. The local environment and macrophage subset determine immune response: tolerance, associated with an M2-like, regulatory macrophage phenotype and inflammatory activation with an …
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A Novel Mechanism of Enhanced Susceptibility to Bacterial Pneumonia in Influenza-infected Hosts
… Streptococcus pneumoniae. Lungresident alveolar macrophages (AMs) act as the first line of innate cellular immunity against respiratory bacterial pathogens, including pneumococcus. Therefore, they represent an attractive target for study Before investigating the impact of influenza infection on …
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Human immunodeficiency virus (HIV)-mediated cardiac fibrosis: implication of cellular immunomodulation and cytokine profile alterations
… this hypothesis, we evaluated changes in T-cell subsets (T-helper cell 1 (Th1) and T-helper cell 2 (Th2)), monocyte/macrophage subsets (macrophage type 1 (M1) and macrophage type 2 (M2)) and circulating fibrocyte subsets (CD34+, collagen 1 [COL1+]). We further examined how these immune and …