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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Macrophage Activation"”.
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Distinguishing Macrophage Activation States by Mass Spectrometry
<p>Macrophages are versatile and highly adaptive cells that are involved in a wide range of physiological processes including host defense, homeostasis or regeneration, as well as pathogenesis. They react to their microenvironment, assuming various roles based on chemical and/or physical cues, and …
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Diet Modifies the Neuroimmune System by Influencing Macrophage Activation
Macrophage activation encompasses a wide range of phenotypes, from classical to alternative activation. Cytokines in the local microenvironment influence the activation state of macrophages. During activation of the neuroimmune system, antigen presenting cells, such as macrophages, produce …
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Cytoskeletal Protein Phosphorylation in the Murine Macrophage and Its Relationship to Macrophage Activation
Made available in DSpace on 2014-12-16T06:35:39Z (GMT). No. of bitstreams: 1 8521760.pdf: 2986168 bytes, checksum: dba94e02f83309292beff25ae06763fa (MD5) Previous issue date: 1985
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Identification of genes involved in macrophage activation and effector functions against intracellular pathogens
This dissertation addressed the hypothesis that macrophages have an alternative killing mechanism that is independent of superoxide and nitric oxide but dependent on IFN-γ, TNF and C/EBPβ. Since the mechanism and the genes involved in this alternative pathway are mostly unknown, the aim of this …
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A novel bioinformatic approach for comprehensive genome scale analysis identifies key regulators of macrophage activation.
… system activates its first line of defense. Macrophage activation by the Toll-like Receptor 4 (TLR4) pathway is initiated with receptor binding of lipopolysaccharides (LPS) and culminates in a large-scale transcriptional response of the inflammatory gene program. Advancements in genome-wide …
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Macrophage Activation Profile and Phenotype Are Regulated by Metabolic Pathways and Are Altered by Diabetic Conditions
… of the most important of these regulators is the macrophage. Macrophages are the bridge between the adaptive and innate immune system and are capable of assuming numerous phenotypes depending on the microenvironment, some proinflammatory and others anti-inflammatory. These relationships are …
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Role of growth hormone and prolactin in regulating T-dependent immune responses and macrophage activation in aged rats
… certain T cell, natural killer cell (NK), and macrophage-mediated responses.
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Splenic Regulation Of Macrophage Activity In Mice Infected With Listeria Monocytogenes
… The regulatory role of the spleen over macrophage activation in mice was investigated. The macrophage migration inhibition test was used to measure in vitro macrophage activity. Macrophages from splenectomized, infected mice were shown to have increased migration and therefore increased …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… with persistent neuronal damage, monocyte/macrophage activation, chronic inflammation, and oxidative stress. Heme oxygenase-1 (HO-1) is a highly inducible, detoxifying enzyme critical for limiting oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) …
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DISSECTING THE ROLE OF THE TETRASPANIN MS4A4A IN MODULATING MACROPHAGE PLASTICITY AND FUNCTION
… Ig receptors. MS4A4A is selectively expressed by macrophages, and its expression is upregulated upon treatment with Interleukin-4 (IL-4) and glucocorticoids (Dexamethasone, Dex). However, the molecular mechanisms by which MS4A4A exerts its biological function in macrophages remains largely …
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The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis
… increased survival and cellular immunity with macrophage activation. Therefore IL-4Rα gene-deficient mice have increased resistance to Mycobacterium tuberculosis infection.
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Modulating the Inflammatory Response of Macrophages on Biomaterial Surfaces
… implanted materials is carried out primarily by macrophages, which recognize DAMPs and other surface-adsorbed proteins with toll-like receptors (TLRs), initiating an inflammatory response. Macrophages play key roles in inflammatory and wound healing responses due to their ability to transition …
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Role of Macrophages in Ocular Surface Fibrosis
… marrow prior to transplantation could trigger macrophage activation and polarization and whether macrophages could cause the transdifferentiation of ocular surface fibroblasts into myofibroblasts, thus contributing to oGVHD-associated fibrosis.</p> <p>Bone marrow cells were cultured in M-CSF to …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… acts as an antagonist to prevent TLR2 and TLR4 activation by bacterial ligands. In this work, we aimed to investigate the role of CD44 receptor and its ligands HA in regulating the activation of macrophages in response to TLR2 receptor stimulation in the context of an acute inflammatory response …
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Effects of ARVs and HIV on mitochondrial function and immune activation in monocyte derived macrophages in vitro
… a form of accelerated aging and comorbidity. Macrophage activation drives persistent inflammation but the molecular mechanisms remain poorly understood. Uninfected and HIV-infected MDMs were treated with ARVs: TFV, 3TC, and EFV, and alterations in cell viability and mitochondrial function were …
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A Study on the Effectiveness of Activated Murine Peritoneal Macrophages in Killing Candida Albicans Hyphae
… plays a vital role in resistance to candidosis, macrophages, phagocytic cells of the immune system, are particularly important in elimination of Candida. When activated, macrophages exhibit increased candidaciadal activity. Previous studies have focused on the ability of activated macrophages to …
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Characterization of interleukin-4 induced gene-1 (IL-4I1) as a host immunoregulator to cutaneous leishmaniasis in cell based models
Macrophage activation can be split into two distinct groups: Classically-Activated (M1) and Alternatively-Activated (M2) macrophages. Each are associated with a certain immune response; in the context of cutaneous leishmaniasis caused by infection with Leishmania major. Specifically, M1 macrophages …
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Splenic Regulation Of Cell Mediated Immunity To Listeria Monocytogenes: Suppression Of Macrophages
… activity. The nature of splenic regulation of macrophage activity was investigated. To determine if suppression was cellular or humoral, splenectomized mice were reconstituted with normal syngeneic spleen cells and normal plasma from Listeria-stimulated normal donors. Mice receiving spleen …
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STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
… kinase SYK, which is important both for macrophage activation and phagocytosis, might underlie much of this pathology. Recent evidence from our lab indicates that SYK can associate with stress granules, ribonucleoprotein particles that form in stressed cells and contain inactive …
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