Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"Macromolecule"”.
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Physical Properties of Magnetic Macromolecule-Metal and Macromolecule-Metal Oxide Nanoparticle Complexes
Magnetic nanoparticles are of considerable interest owing to their potential applications in biotechnology and the magnetic recording industry. Iron oxides have received much attention owing to their oxidative stability and biocompatibility; however, other transition metals and their alloys are …
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Convective intracellular macromolecule delivery for cell engineering applications
Efficient intracellular delivery of target macromolecules remains a major obstacle in cell engineering, cell labeling, and other biomedical applications. Current standard methods of intracellular delivery, such as viral transduction and electroporation, do not meet the growing needs in the cell …
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Macromolecule Loading on PLGA Particles through Surface Adsorption
… made in using polymeric particles as carriers of macromolecule drugs. Historically the method is to encapsulate biological drugs into spherical polymeric matrices. Owing to its biocompatible and biodegradable nature, poly (d,l-lactic-co-glycolic acid) (PLGA) has been used extensively in …
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Studies of Macromolecule/Molecule Adsorption and Activity at Interfaces
Interfaces are ubiquitous in our daily life. A good understanding of the interfacial properties between different materials, or a single material in different physical states is of critical importance for us to explore the current world and bring benefits to mankind. In this work, interfacial …
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Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract
… substances composed of large and complex "macromolecules." Examples include vaccines, insulin, monoclonal antibodies, and allergens. However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered …
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Design of Nuclear-Targeting Peptides for Macromolecule Delivery via Machine Learning
… were nontoxic, able to deliver other biomacromolecules to the cytosol, and efficiently delivered antisense cargo in mice. A different approach to discover and characterize CPP sequences was also taken, by extracting peptides taken up into cells and analyzing their relative quantities or …
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Preparation and Functionalization of Macromolecule-Metal and Metal Oxide Nanocomplexes for Biomedical Applications
… mechanical grinding. Aqueous dispersions of macromolecule-magnetite complexes are desirable for biomedical applications. A series of vinylsilylpropanol initiators, where the vinyl groups vary from one to three, were prepared and utilized for the synthesis of heterobifunctional poly(ethylene …
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Development and physical characterisation of polyethylene glycol glycerides-based gel formulations for macromolecule delivery
Lipid-based delivery systems offer many advantages on enhancing the bioavailability of protein/peptides. Gelucire 50/13 is a complex mixture of glycerides and PEG. It is mainly used in solid oral formulations for delivering small molecular weight drugs. The purpose of this project was to develop …
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Physical Properties of Macromolecule-metal oxide nanoparticle complexes: Magnetophoretic Mobility, Size, and Interparticle Potentials
Magnetic nanoparticles coated with polymers hold great promise as materials for applications in biotechnology. In this body of work, magnetic fluids for the treatment of retinal detachment are examined closely in three regimes; motion of ferrofluid droplets in aqueous media, size analysis of the …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
One of the major focus areas of anticancer therapy is the design of new radiotherapeutic agents that are able to specifically target and destroy cancer cells with minimal side effects and damage to healthy, normal cells. This thesis describes studies towards the synthesis of a macromolecular …
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Engineering Resistance to <i>Orobanche</i> <i>aegyptiaca</i>: Evidence of Sarcotoxin IA as an Anti-Parasite Protein and Macromolecule Movement From Host to Parasite
… has been documented, movement of macromolecules between host and parasite has not been characterized. The objectives of this research were to 1) determine whether, and by what route, host macromolecules can be translocated to the parasite, and 2) engineer host resistance based on …
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Determination of capillary electrophoretic methodology and its application as a mechanistic tool for gaining insight into the composition of, and detergent action on, coloured macromolecule fabric stains.
A range of Capillary Electrophoresis (CE) techniques have been developed for the analysis of various chemical components in a range of real matrices. The techniques developed have then been used as a tool for monitoring the chemistry of complex systems. The use of such methods is a novel …
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Ingestible capsules for therapeutic injections in the gastrointestinal tract
Macromolecule drugs such as insulin have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limits their administration to parenteral routes. An oral biologic delivery system must aid in both …
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The synthesis of unimolecular polymers through iterative exponential growth and their applications in block copolymer phase segregation and biological systems
… ability to control the primary structure of a macromolecule and the ability to scale the production of the same macromolecule. In this thesis, we describe the application of iterative exponential growth (IEG) toward the scalable synthesis of sequence-defined, unimolecular, chiral polymers. …
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Extended mechanical stimulations of cartilage for growth and repair
… results in long term extracelluar matrix macromolecule biosynthesis and increased biosynthetic rates in the cartilage system. The protocol uses total glycosaminoglycan and DNA content assays to measure matrix macromolecule biosynthesis and uses L-³H-proline and ³⁵S-sulfate radiolabel …
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Macroscopic continuum and molecular dynamics modeling and simulation studies of the transport and adsorption of charged macromolecules in ion-exchange chromatography systems
… in the concentration of a charged bioactive macromolecule in the adsorbed phase of charged adsorbent particles is presented, and the parametric sensitivity of the concentration overshoot phenomenon with respect to its enhancement or suppression is studied. Practical implications of this …
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Lignin biodegradation: reduced oxygen species
… cross-linked, polymeric structure of the lignin macromolecule makes its direct uptake, during the initial stages of its degradation, by microbial cells improbable. Moreover, the fact that the lignin macromolecule is composed of different monomeric units linked by a large variety of …
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Effects of selenite on metabolic events during the proliferation of canine mammary tumor cells
… cells is accompanied by decreased rates of macromolecule synthesis, increased cellular macromolecule contents and increased cell size and multiple nuclei, indicating that enhanced cell fusion occurred. Selenite modulated the S and M phases during the cell cycle. Selenite increased the …
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The design of multifunctional hydrogel nanoparticles for drug delivery
… several attractive features for the delivery of macromolecule therapeutics. For instance, the hydrated, porous internal cavity of the nanogel may serve as a high capacity compartment for loading macromolecules, whereas the periphery of the nanogel may be used as a scaffold for conjugating …
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