Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Macromolecular signaling complex"”.
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
<p>The signaling mediated by the chemokine receptor CXC chemokine receptor 2 (CXCR2) plays an important role in promoting the progression of many cancers, including pancreatic cancer, one of the most lethal human malignancies. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl …
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Structural Basis Of Epigenetic Regulation And Protein Scaffolding In Development And Diseases
… substrate, estrogen receptor alpha (ERα). The complex structure revealed that ERα peptide binds SMYD2 in a U-shaped conformation with the binding specificity determined predominantly by residues C-terminal to the target lysine. The structure also showed that the broad specificity of SMYD2 is …