Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Macromolecular crystallography"”.
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An exploration of some aspects of molecular replacement in macromolecular crystallography
This thesis reports work in three areas of X-ray crystallography. An initial chapter describes the structure of a protein, the methods based on the use of X-rays and computer analysis of diffraction patterns to determine crystal structure, and the subsequent derivation of the structure of part or …
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Statistically robust methods for the integration and analysis of X-ray diffraction data from pixel array detectors
… of data collection, such as serial synchrotron crystallography (SSX), in macromolecular crystallography at synchrotrons. This in turn is creating the need for better algorithms and software to extract the maximum amount of information from the diffraction data. The aim of this project is to …
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Structural characterization of the type II secretion system of Aeromonas hydrophila
… to grow single crystals for analysis by X-ray crystallography. Crystals comprised of the PDZ domain from a degraded construct grew in a hexagonal space group with a hexagonal bi-pyramidal morphology. Crystals diffracted anisotropically to a maximum resolutions of 2 Å along the c axis and 3 Å in …
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Structural studies of putative general stress and related proteins from Deinococcus radiodurans
… on secondment at the ESRF, working within the Macromolecular Crystallography Group. Several constructs of the dr_1146 gene have been successfully overexpressed in E. coli cells to give high yields of target protein. Purification by immobilised metal affinity chromatography (IMAC) was …
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Characterization and design of hydrogen bonding interactions in oxygen reduction by engineered myoglobins
"Proteins participate in nearly every function of living cells, and an estimated 50% are associated with a metal ion or cofactor. Most, if not all, of the fundamental chemical processes necessary for life, including photosynthesis and respiration, are facilitated by one or more metalloenzymes or …