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Showing 1 to 9 of 9 for “"Macrolactonization"”.
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I. Chemoselective Dehydrative Glycosylation With Application Toward Oligosaccharide Synthesis. II. Sulfide-Mediated Direct Glycosylation of C(1)-Hydroxyl Glycosyl Donors. III. Studies Toward the Total Synthesis of Auriside A
… aldol reaction, the intramolecular Mitsunobu macrolactonization, and the Julia olefination for the installation of the C(5)-stereogenic center, the 14-membered macrolactone, and the conjugated bromodiene moiety, respectively.
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Total Synthesis of (+)-nemorensic acid: En Route to (-)-callosine
… appending the ansa bridge via esterification and macrolactonization are discussed.
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C—H oxidation reactions in complex molecule synthesis: application and development
… using a late-stage (step 19 of 22) C–H oxidative macrolactonization reaction that proceeds with high regio-, chemo-, and diastereoselectivity (>40:1). A chelate-controlled model for macrolactonization predicted the stereochemical outcome of C–O bond formation and guided the discovery of conditions …
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Phosphine-promoted cross-coupling reactions of propargylcopper reagents and alkenyl iodides and the total synthesis of (-)-gloeosporone via nickel-catalyzed epoxide-alkyne reductive macrocyclization
… of 1 using more traditional approaches such as macrolactonization and ring-closing metathesis. ...
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Nickel-catalyzed reductive coupling reactions of 1,6-enynes and the total synthesis of (+)-acutiphycin
… SmI2-mediated Reformatsky coupling reaction and macrolactonization initiated by a retro-ene reaction of an alkoxyalkyne was developed. The resulting synthesis was 18 steps in the longest linear sequence from either methyl acetoacetate or isobutyraldehyde. ...
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The progress towards the total synthesis of (ent)-MPC1001
… provided irreproducible results. Therefore, a macrolactonization was utilized to synthesize an advanced lactone derivative. Current research is focused on the elaboration of the lactone to the oxepin ring. Efforts were also focused on the development of a novel β-hydroxy-α-amino acid derivative …
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APPROACHES TO THE TOTAL SYNTHESIS OF DICTYOSTATIN AND SYNTHESIS OF EPI-DICTYOSTATINS
… C1-C9 and C10-C26, followed by Yamaguchi macrolactonization and global deprotection. Eleven stereogenic centers and four stereogenic double bonds were obtained with a high level of stereocontrol. Surprisingly, the addition of vinylzincate C10-C26 to aldehyde C1-C9 led to a complete …
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Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization
… these two demonstrated the ability to catalyze macrolactonization with minimal competing hydrolysis reactivity, making them promising biocatalysts. An uncommon tandem TE domain was also characterized, revealing its tolerance for N-terminal peptide modification, peptide sequence composition and …
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I. Progress Toward Leiodelide A II. Palladium-Catalyzed Reactions of Enol Ethers
… macrolactone could not be closed using Mitsunobu macrolactonization conditions, but an alternate route has been devised in order to complete the total synthesis of leiodelide A.</p><p>A palladium-catalyzed oxidation of alkyl enol ethers to ¿¿,¿¿-unsaturated aldehydes was developed. The reaction …