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Showing 1 to 16 of 16 for “"Macrocyclic compounds"”.
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… in one tumour avid compound. A series of novel macrocyclic chelators based around the cyclen framework have been successfully synthesised, each containing a functional handle for further elaboration of the structure. The amino bearing derivatives have been successfully coupled to a porphyrin …
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Magnetic and Electronic Properties of Di- and Tetra-Nuclear Mixed-Valence Iron Compounds and High-Spin Five-Coordinate Ferrous Macrocyclic Compounds
Made available in DSpace on 2014-12-13T20:10:21Z (GMT). No. of bitstreams: 1 7804197.pdf: 10969322 bytes, checksum: 567353d1227b18d8a5b9a2f76881d720 (MD5) Previous issue date: 1977
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The synthesis, characterization, and application of carborane-cluster based macrocycles and boron nitride nanosheets in photovoltaics
… By incorporating carborane cluster-based macrocyclic compounds as "electron reservoirs," a number of the inherent limitations in DSSC systems can be potentially circumvented, including extending the useable photon energy into the IR region by using a multi-photon, multi-step mechanism, …
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The Synthesis and Application of 1,4-Dithiins, Thianthrenes, and Other Sulfur-Rich Scaffolds
… and applications of various sulfur rich compounds, focusing on 1,4-dithiins, thianthrenes, and new sulfur-rich macrocycles. In Chapter 1, we offer a review of the properties, general synthesis, and materials application of 1,4-dithiins and thianthrenes. Additionally, the installation of …
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Configurationally restricted bis-tetraazamacrocyclic complexes: chemokine receptor antagonists
… identified as a potential therapeutic target.Bis-macrocyclic drugs (e.g. AMDS 100) bind to aspartate residues on the CXCR4 surface and inhibit HIV replication by blocking the interaction of gp!20/gp41 with the protein. The incorporation of transition metals (e.g. zinc(II) and copper(II)) into the …
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Synthesis of novel pendant arm macrocyclic ligands as potential models for enterobactin
A series of pendant arm tris-catecholate macrocyclic ligands were synthesized. The first, based on 1,4,7- triaminopropyl-1, 4, 7-triazacyclononane, was prepared via condensation with 2,3-dimethoxybenzoyl chloride. The deprotection of the catechol moieties was achieved with boron tribromide in 80% …
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Synthesis and properties of novel macrocycles and related chromophoric benzenoid compounds
The synthesis and properties of some macrocyclic compounds of interest are presented. Resorcinarenes with functionalized conjugated rigid rods made of oligo-p-phenylenes would lead to an entirely new class of functional, soluble, well-defined architectures impacting a variety of multidisciplinary …
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Detection of Biologically Important Molecules
… the origin of color formation in resorcinarene macrocyclic compounds is explained in detail. The in situ acid formation from DMSO decomposition can cause the ring-opening of resorcinarenes followed by the condensation of resultant products to afford xanthene dyes. This discovery has influenced …
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Evaluation of new PET tracers for receptor tumour imaging
… in vivo. In this study, novel restricted CXCR4 macrocyclic compounds synthesized by Archibald and co-workers, Cu2CB-Bicyclam and CuCB-Bicyclam were tested and shown to be potent CXCR4 antagonists, with improved characteristics in comparison with the clinically approved AMD3100 and related …
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Synthesis and Coordination Chemistry of Functionalised Phosphazanes
… and their use as ligands and building blocks for macrocyclic compounds. The introduction (Chapter 1) surveys previous literature in the area, which is pertinent to the new studies. One of the most important issues is the various ways in which dimeric phosph(III)azanes can be employed as precursors …
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Synthesis and characterization of phosphorous containing macromolecular polyether compounds
<p>A radioisotope of rubidium, <sup>82</sup>Rb is used in positron emission tomography. Neutral crown ethers and cryptands have been studied as carrier ligands for Rb<sup>+</sup> but exhibit low ion carrying capacity and high toxicity. The present study involved investigating a lariat ether …
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Total Synthesis of Mangrolide A
The discovery of antibiotics in the 1930s played a critical role in human health by treatment of patients with kinds of infections. During the 'golden era' of antibiotic research, various antibiotics were discovered. The emergence of multi-drug-resistant bacteria has jeopardized the human health. …
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Photochemical synthesis of dihydroquinolinones and their investigation toward macrocycle synthesis via ring expansion
There are several macrocyclic drugs that are currently on the market. As representative examples, erythromycin and azithromycin are currently approved antibiotics. Macrocycles are also used to treat other infectious diseases, for example, natamycin and amphotericin B are used as antifungal agents …
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NMR characterization of a diiron macrocycle and structural characterization of a diketo derivative
… the value for partial double bonds of aromatic compounds. This argues for a delocalized electron circulating within the macrocycle.</p><p>The NMR spectra of a diiron macrocycle, [Fe<sub>2</sub>(TIED)(CH<sub>3</sub>CN)<sub>4</sub>]<sup>4+</sup>, were examined. Temperature dependent, pH dependent, …