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Showing 1 to 1 of 1 for “"Macrocycle bisintercalator"”.
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Development of enforced stacked intercalators that target trinucleotide repeat mismatches in DNA
… design, and developed a small library of macrocycles. We showed that these ligands selectively bind to CTG trinucleotide repeats in DNA with negligible nonspecific binding to duplex DNA. In addition, they were about twice as effective and selective in inhibiting transcription than the …