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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 229 for “"Mab"”.
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Analysis of Modified Ascending Bekesy (Mab) Tracings
Made available in DSpace on 2014-12-11T23:56:07Z (GMT). No. of bitstreams: 1 7114813.pdf: 4200143 bytes, checksum: a853ad00bc4df6d4cc186d79a8559f59 (MD5) Previous issue date: 1970
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Monoclonal antibody (mAb) purification by counter current chromatography (CCC)
… scalable purification of monoclonal antibodies (mAb) from mammalian cell culture, using aqueous two-phase systems (ATPS) of inorganic salts and polymer. A polyethylene glycol (PEG) and sodium citrate system was found to be the most appropriate by robotic phase system selection. The search for an …
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Radioimmunotherapy in an Immunocompetent Tumor Model utilizing a 177Lu-mAb
Radioimmunotherapy (RIT) is a therapeutic strategy in which radionuclides are conjugated to monoclonal antibodies that bind to tumor-associated antigens in the tumor, so that the decay of the radionuclide takes place inside the tumor. The aim of the research presented in this thesis was to …
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Aggregation of IgG mAb Biotherapeutics: Sources, Methods of Characterization, and Biological Implications
… different IgG monoclonal antibodies (2 IgG1 mAbs, one in solution and one in lyophilized form and one IgG2 mAb in solution) were stressed by a variety of different conditions and the resulting aggregates and particles were characterized using a broad array of methods. Some of the …
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Reconciling biodiversity preservation and local sustainable development : the role of the "MAB biosphere reserves" in the South-Eastern European countries
… in the frame of the UNESCO Man and Biosphere (MAB) Programme, which lead to the publication (2002) of the book entitled 'Biosphere Reserves: special places for Nature and People'. The volume intended to comprehensively summarise the main steps of the Programme's history, as well as the …
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Analysing M. abscessus-macrophage interactions and investigating treatments for M. abscessus and S. aureus intracellular bacterial infections, using a continuously growing, primary cell model of lung alveolar macrophages
INTRODUCTION - Mycobacterium abscessus (MAB) and Staphylococcus aureus (SA) are bacterial pathogens capable of causing a range of infections in humans, and pulmonary infections are significant amongst them. During pulmonary infection, alveolar macrophages (AMs), as sentinel immune cells of the …
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Investigating "difficult-to-express" monoclonal antibody frameworks in transient and site-specific integration-based Chinese hamster ovary cell expression systems
The success of a monoclonal antibody (mAb) product is dependent on both its clinical performance and its “developability” profile, a set of characteristics that defines its ability to be manufactured at large-scale using current practices in the biopharmaceutical industry. Failure to identify low …
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Herstellung und Charakterisierung monoklonaler Antikörper gegen equine Leukozyten
… 78 clons were isolated. To characterize the mAbs, the attention was focused on immunofluorescence analysis. Antibodies of the clones 4-13, 4-58, 1-19 and 6-39 have been purified by protein G-sepharoses chromatography and, except mAb 4-58, biotinylated. MAb 4-13, mAb 4-58 and mAb 5-50 are …
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The C. elegans heterochronic pathway controls the timing of NAB/EGR-mediated terminal differentiation and the onset of adulthood
… new alleles of the previously identified gene mab-10. I then clone mab-10, showing that it encodes the only C. elegans NAB family transcriptional cofactor. I go on to show that MAB- 10 acts with LIN-29 to control the larval-to-adult transition and that LIN-29 shares homology with mammalian EGR …
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Investigation of Inter-Individual Variability in Monoclonal Antibody Disposition
… variability (IIV) in monoclonal antibody (mAb) pharmacokinetics has been reported in the clinic. The sources of variability are not well understood and often not explored. Very few preclinical and clinical studies have attempted to examine the sources of IIV. Preclinical investigations, …
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Active Inhibition of T Cell Proliferation by Monocytes
<p>Monoclonal antibodies (mAb) to MHC class II molecules (anti-class II mAb) have been well described in their ability to inhibit T cell activation. The most current model is that anti-class II mAb interfere directly with the T cell receptor-major histocompatibility complex crosslinking which is …
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On upper confidence bound algorithms for piecewise-stationary stochastic multi-armed bandits and the variants
In recent years, multi-armed bandit (MAB) problems have received much attention, as they model many real-world applications such as online recommendation, web search and crowdsourcing tasks. The core of MAB algorithms is addressing the exploration versus exploitation dilemma, and finding the right …
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In Vitro Evaluation of Cancer Patient Immune Responses Following Infusion of Radiolabeled Murine Monoclonal Antibody
<p>Several monoclonal antibody (MAb) types derived from mice have been developed specifically for the use of targeting human tumors. The specificity of these murine MAb’s for their respective tumor antigens is very high making them potentially good immunotherapeutic agents for cancer treatment and …
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Potentiating Antibody Therapy by Targeting Complement on Cancer Cells
BACKGROUND: Monoclonal antibodies (mAb) are a key component of treatment regimens for hematologic malignancies, but mAb-induced antigen loss on tumor cells can lead to treatment failure. Loss of cell surface CD20 can occur in the treatment of lymphoid malignancies with anti-CD20 antibodies (mAbs) …
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Characterization of equine neutrophil surface antigens with an anti-β-integrin-like and two anti-CD18 monoclonal antibodies and effect of lipopolysaccharide stimulation
… to 30 day intervals. The monoclonal antibodies (MAb) 60.3 and #38 recognize portions of CD18, the β₂-subunit of heterodimeric integrins LFA-1 (i.e. CD11a/CD18), Mac-1 (i.e. CD11b/CD18) and p150,95 (i.e. CD11c/CD18). Monoclonal antibody #25 putatively recognizes a β-integrin-like surface antigen. …
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The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics
… response to a therapeutic monoclonal antibody (mAb). Several approaches can be used to limit or capture the changes in the pharmacokinetics of a medication caused by ontogeny and immune reactivity related dynamic changes. Three approaches were investigated in this dissertation: 1) …
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Utilization of Model-Based Approaches to Maximize Efficacy of Antibiotics for the Treatment of Mycobacterium abscessus Pulmonary Infection
… and incidence of Mycobacterium abscessus (Mab) pulmonary infections have increased and been recognized as a major cause of mortality, particularly in certain patient populations, such as cystic fibrosis (CF) patients. Due to the intrinsic multidrug resistance mechanisms and biofilm (BF) …
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New roles for Hox and Wnt in Cell Migration
… EGL-20/Wnt results in trasncription of mab-5/Antennapedia/Hox through canonical Wnt signalling. MAB-5 is a posterior migration determinant of the QL lineage, and expression of mab-5 is necessary and sufficient for posterior migration. lin-39/Sex combs reduced/Hox is activated through …
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