Global ETD Search
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Showing 1 to 6 of 6 for “"MYPT1"”.
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Alternative splicing of the zebrafish myosin phosphatase targeting subunit, MYPT1, produces a novel isoform
… zebrafish Myosin Phosphatase Targeting Subunit, MYPT1, produces a novel isoform (TV202). TV202 and the truncated TV202Δ ere shown to form an active complex with Protein Phosphatase 1 β (PP1β) via stress fiber assay. TV202 was also shown to be localized in the cytoplasm, enriched in a paranuclear …
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Characterization of Parkinson's Disease-associated LRRK2 Kinase
… the initial aim was to address whether or not MYPT1 comprised a physiological substrate of LRRK2, and if so to investigate whether it was involved in the negative feedback regulation of LRRK2 on S910/S935. For this purpose, I used transcription activator-like effector nucleases (TALENs) as well …
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Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… distinct GI regions. ã-actin, total and phospho-MYPT1 (pT696, pT853), total and phospho-CPI-17 (pT38), and total and phospho-MLC20 (pS19) were determined during spontaneous contraction of these three smooth muscles. The expression levels of the LZ+ and LZ- MYPT1 isoforms, and the MLCP-anchoring …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… interacting proteins were identified including MYPT1, NIPP1, Inhibitor-2 and Staufen. Interestingly, three glycogen-related proteins, namely R6, glycogenin and glycogen synthase, were found to be highly enriched upon forskolin treatment which included prior inhibition of the pathway with H-89. …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… of the myosin light chain phosphatase subunit MYPT1. The contractions induced by muscarinic receptor agonists are characterized by increased phasic activity in the newborn. This activity is not dependent on K+ channels, calcium release from the sarcoplasmic reticulum or gap junctional …
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Characterization of zebrafish zipper-interacting protein kinase
<p>Zipper-Interacting Protein Kinase (ZIPK) is a known modulator of actin-myosin contractility in vertebrate species. Interestingly, rodent and mouse ZIPK has undergone a divergence in regulation in comparison to other vertebrate orthologs including human. Whereas the human ortholog of ZIPK …