Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"MYCBP2"”.
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Design and Synthesis of an E3 ligase Activity-Based Probe and its Application for the Discovery of a New Class of E3 Ligase
… it to uncover a new class of E3. We show that MYCBP2 is an E3 ligase with a novel mechanism of action that ubiquitylates threonine residues. MYCBP2 contains a RING domain, that recruits the ubiquitin-loaded E2, and a novel Zn-binding fold that contains two catalytic cysteine residues which …
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Exploring SARM1 as a target to delay programmed axon degeneration
… of pro-survival factor NMNAT2, and removal of MYCBP2 involved in protein ubiquitination and turnover, or prodegenerative protein SARM1 can delay programmed axon degeneration. Preclinical studies indicate that complete genetic removal of Sarm1 leads to the strongest protection in vivo after …