Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"MXI1"”.
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Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… prognostic marker in neuroblastoma. The MXI1 (MAX-interactor 1) gene, a reported MYC antagonist, has been detected by us and others as a commonly hypoxia-induced gene. In Paper III we further demonstrate that HIF proteins, via direct binding to hypoxia-response elements (HRE), up-regulate …
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Development of CRISPR/Cas9-based gene drive biotechnology in S. cerevisiae
… when tagged with the transcriptional repressor Mxi1.
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Identification and Functional Characterization of Novel Genes Involved in Primary Neurogenesis in Xenopus laevis
… XPak3, eine Serin/Threonin Proteinkinase, und X-Mxi1, ein basisches Helix-Loop-Helix Leucin Zipper Protein, die beide zur N-tubulin Synexpressionsgruppe gehören, sowie XSeb4, ein RRM-Typ RNA bindendes Protein, das zur Delta Synexpressionsgruppe gehört. Basierend auf der Tatsache, dass XPak3 und …
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MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation
… set of genomic regulators, (e.g. CEBPα , MXI1 and SIN3A). Using a combination of mouse models and systems biology tools, I then identified SIN3A as a key regulator in this MYC-dependent transcriptional network. I found that MYC and SIN3A form a negative feedback loop, which is required to …
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Transcriptional functions of the corepressor Sin3A in skin
… discovered via its direct interaction with Mxi1 and Mxd1, which are antagonists of the Myc family network. As such, I concentrated on the role of Sin3A as a potential opposing factor to c-Myc activity in the epidermis. To analyse the role of Sin3A in regulating epidermal stem cell fate in …