Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"MVB"”.
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Molecular Mechanisms of Inward and Outward Budding From Multivesicular Endosomes
… of the late endosome/multivesicular body (MVB) is dictated by whether they remain on the limiting membrane, bud into internal MVB vesicles, or bud outwardly from the membrane. The molecular details underlying the disposition of membrane proteins that transit this pathway and the mechanisms …
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Regulation of The Escrt Function of Alix
… classical ESCRT-mediated processes, including MVB (multivesicular body) sorting, cytokinetic abscission and retroviral budding. Previous studies have demonstrated that ALIX involvement in these ESCRT-mediated processes requires ALIX interaction with the ESCRT-III component CHMP4 as well as a …
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Characterization of The Ubiquitin Ligase, Ube4B, In Endocytic Trafficking
… bud into the lumen of the multivesicular body (MVB). Inclusion into internal MVB vesicles designates EGFR for lysosomal proteolysis and extinguishes their signaling activity.</p> <p>Ubiquitination is a post-translational modification that underlies some aspects of membrane protein trafficking. …
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The Ubiquitin Ligase Ube4B Is Required For Efficient Epidermal Growth Factor Receptor Degradation
… late endosomes/multivesicular bodies (MVBs), before being degraded in the lysosome. The MVB is a subset of late endosomes characterized by the appearance of small vesicles in its luminal compartment. These vesicles contain cargo proteins sorted from the limiting membrane of the MVB. …
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Role And Regulation Of ESCRT-III In Multivesiculr Body Biogenesis
… machinery responsible for multivesicular body: MVB) biogenesis is essential for receptor downregulation, viral budding and cytokinesis. ESCRT-III is a large polymer built from related ESCRT-III proteins that is thought to help generate intralumenal vesicles: ILVs) within the MVB. How ESCRT-III …
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Endosomal Trafficking and Exosomal Secretion of Egfrviii
… of late endosomes / multivesicular bodies (MVBs) but does not follow the canonical pathway by which wild-type EGFR is degraded following MVB fusion with lysosomes. I determined that EGFRvIII is secreted on exosomes, the intraluminal vesicles that are secreted upon MVB fusion with the plasma …
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Assessment of endosomes as sites of signal transduction in plants during bacterial attack
… in RFPRABF2b/ARA7 and RABF1/ARA6-RFP labelled LE/MVBs and their interaction with the TGN. Assessment of endosomal proteomes after flagellin treatment reveals a potential role for LE/MVB mediated secretion of flavonols in pathogen defence. Moreover, MPK cascade components were found in endosomal …
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Driving performance in mild dementia
… level of hierarchy. A Motor Vehicle Branch (MVB) road test and a test of emergency braking distance indexed the intermediate level. Driving-related judgment was assessed by evaluating the accuracy of subjects' appraisals of their own driving skills, and by examining whether the demented …
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Chemical Ecology of Defense Compounds in Anasa Species (Heteroptera: Coreidae) and Volatile Attractants for Diabrotica Species (Coleoptera: Chrysomelidae) (Attractants, Glands, Corn Rootworms, Electron Microscopy, Squash Bug)
… high metabolic activity. Multivesicular bodies (MVB) were frequently found adjacent to the end-apparatus (microvilli and collecting area) and may function in secretory or autolytic activities. The duct cells surround cuticular-lined ductules and the lumen of the gland tubule. Septate desomosomes …
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
… vesicles of late endosome/multivesicular bodies (MVB) is dependent on Endosomal Sorting Complexes Required for Transport (ESCRT) machinery. This implied that APP is ubiquitinated to allow ESCRT interactions. We then identified that the endosome-associated E3 ubiquitin ligase, UBE4B, is required …
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Molecular Analysis of the Unconventional Export Machinery of HASPB, a component of the surface coat of Leishmania parasites
… be exported via vesicles being released by the MVB sorting machinery. Furthermore employing linear sucrose gradients and electron microscopy, these vesicles corresponded to the reported density of 1.15 g/ml for exosomes (Heijnen et al., 1999) as well as to the exosomal size with diameters <100 …
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The Membrane as a barrier or target in cancer chemotherapy
… in either cell line. A series of compounds, PVB, MVB and MOVB, based on the skeleton of VBBO was examined. VBBO was found to be the most effective photosensitizer. The rate of uptake for VBBO, MVB and PVB appeared to be very similar, whereas that of MOVB was slower. The uptake/dose trend was also …
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Mechanisms of Multivesicular Body Biogenesis and Exosome Release
… von der Docking/Tethering zwischen die MVB und der Plasmamembran. Dass Rab35 zusammen mit nicht-kompaktem Myelin, welches MVE beinhaltet, aufgereinigt werden kann, lässt vermuten, dass die Biogenese von Exosomen auch in der Funktion des zentralen Nervensystems eine Rolle spielt.
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Ultrastructural analysis of HIV-1 infection in human cells
… endosomalen Kompartiments (multivesicular body, MVB) als auch bei der Bildung dieser Vesikel eine Rolle. ESCRT fand sich im gesamten endosomalen System einschliesslich der Plasmamembran, und war besonders an tubulär-vesikulären endosomalen Membranen, aber nicht an MVBs, angereichert. Entgegen der …
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The mode of action of Epicoccum derived antimicrobials
… protein endocytosis and multivesicular body (MVB) sorting pathways, and β-oxidation of fatty acids. To our knowledge, this was the first time to report a polyene class of antifungal compound directly affecting sphingolipids – possibly not ergosterol, which is a well-known target of other drugs …
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Analysis of the maturation of Rhodococcus equi-containing vacuoles in macrophages
… that resemble multivesicular body compartments (MVB), which are transport intermediates between early and late endosomes and display internal vesicles very similar to the ones observed within RCVs. Analyisis of several R.equi strains containing either VapA- or VapB-expressing plasmids or neither …
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Determinanten und Mechanismen der foamyviralen Partikelfreisetzung
… in Multivesikuläre Körperchen (MVB) eine besondere Bedeutung zu kommt. Über die FV virale und subvirale Partikelfreisetzung und die dabei involvierten strukturellen viralen Domänen und zellulären Proteinen war jedoch bisher wenig bekannt. Im Rahmen dieser Arbeit konnte durch …