Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2385 for “"MUTANTS"”.
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Mutants: Ceramic Objects
… philosophy of the exhibition titled Mutants, installed in the Edgar Heap of Birds Family Gallery February 25, 2023. This exhibition consists of eleven ceramic objects that encompass a representative range between figurative sculpture, classical ornamentation and abstract gesture. By …
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Pathogenicity of Murine Cytomegalovirus Mutants
… these genes consisted of constructing MCMV mutants, and then analyzing these mutants in vitro and in vivo. Recombinant viruses (RV) expressing the β-glucuronidase marker gene were constructed by site-directed insertion and deletion mutagenesis of the MCMV Hind III-J and -I regions of the …
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Chromosomal Fragmentation in Escherichia Coli: Its Absence in mutT Mutants and Its Mechanisms in seqA Mutants
While studying mutT and seqA mutants, we discovered a contaminating bacteriophage We studied, sequenced, and identified the phage as phi80. We looked at three interesting phenotypes: modification of the phage DNA to protect against restriction enzymes, sensitivity of lysogens to UV damage, and the …
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Characterization of HIV-1 Rev mutants
… investigation. Curiously, over-expression of Rev mutants R39A, R42A, and the double mutant E47A/E57A also alter doubling times and increase the frequency of multinucleated cells. Taken together, Rev over-expression can lead to defects not directly attributable to Rev-MT interactions.
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Photosynthesis Inhibition in the Arabidopsis Thaliana Photorespiration Mutants
… occurring in the Arabidopsis photorespiration mutants during illumination under atmospheres which promote photorespiration is predominantly due to declining leaf RuBP concentrations resulting from the impairment of carbon recycling to the Calvin cycle.
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Dominant negative mutants of the human estrogen receptor
… characterized three human estrogen receptor (ER) mutants which, at low concentrations, are capable of blocking the intracellular activity of wild type ER. The mutants, a truncated ER (ER1-530), a point mutant (L540Q), and a frameshift (S554fs), were generated by random chemical mutagenesis of the …
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Folding Studies on Mutants of Chymotrypsin Inhibitor 2
The thermodynamics and folding kinetics of mutants at the helix N-terminus and hydrophobic core of Chymotrypsin Inhibitor 2 (CI2) have been studied. All mutants adhere to a two-state model for protein folding , and are destabilised relative to wild-type. Mutation of N-cap residue S31 to Ala or Gly …
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Tryptophan and indole accumulation by Escherichia coli mutants
Thesis: Sc. D., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1964
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Functional Analysis of Wild-Type LGN and T450 Mutants
… biochemistry of both wild-type LGN and two T450 mutants of LGN in hope of gaining insight as to how LGN phosphorylation proliferates cancer. LGN was transiently expressed in BHK-570 tissue culture cells using a pCMV-LGN plasmid and LipoD 293 reagent. Protein expression of wild-type LGN was …
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Characterization of Arabidopsis thaliana mutants defetive in auxin metabolism
… characterized and mapped to chromosome 1. Three mutants potentially defective in the last step of IAA biosynthesis have also been characterized. One of these mutants has been tested for complementation with a gene encoding a putative aldehyde oxidase, AtAO4.
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Solution structure and dynamics of myoglobin and its mutants
This thesis discusses the solution structure and function of sperm whale myoglobin. The solution structure of sperm whale myoglobin, with atomic resolution is obtained by using nuclear magnetic resonance spectroscopy (NMR).
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Functional analysis of KLF2 and its lymphoma-derived mutants
… signalling. All three C-terminal truncation mutants and 8/10 lymphoma derived missense/ indel mutants showed a loss of NOTCH2 suppression. Interestingly, KLF2 C274Y, C279Y, H292Y, H296Y and S287P mutants displayed enhanced reporter activities, suggesting gain of function. Wild type KLF2 was …
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Identification of cell surface assembly mutants in Saccharomyces cerevisiae
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Nuclear magnetic resonance studies of HIV TAR RNA mutants
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Characterization of activation tagged potato (Solanum tuberosum L.) mutants
… and characterization of activation tagged potato mutants could aid in functional genomic studies. Morphological and molecular studies were conducted to compare potato cv. Bintje, its two mutants, underperformer (up), and nikku generated using the activation tagging vector pSKI074, and nikku …
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Generation and Characterization of dszB Mutants from Nocardia asteroides A3H1
Dibenzothiophene, a model compound for sulfur-containing organic molecules found in fossil fuels, can be desulfurized to 2-hydroxybiphenyl by Nocardia asteroides sp. strain A3H1 (A3H1) using the “4S”desulfurization pathway. In the final and rate-limiting step of this pathway, the DszB enzyme …
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Propriétés de divers antigenes grand T mutants du virus polyome
… nous avons étudié les propriétés de différents mutants de délétion du deuxième exon de grand T. Cette région de grand T est impliquée dans l'immortalisation cellulaire. L'antigène grand T a aussi la propriété de transactiver des promoteurs viraux et cellulaires. Nous avons vérifié l'hypothèse …
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Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven By Different P53 Mutants
… incidence in mice expressing <em>p53</em> mutants as compared to <em>p53</em>-null mice, suggesting gain of function. RNA-sequencing of primary osteosarcomas revealed that tumors expressing these missense mutants had vastly different gene expression profiles as compared to <em>p53</em>-null …
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Genetic studies of mutants of Neurospora crassa lacking ornithine transcarbamylase
… and Horowitz (1944) isolated many arginineless mutants of Neurospora crassa and found the mutants confirmed Krebs' claim (1932) that ornithine and citrulline are precursors in the biosynthesis of arginine. With the characterization of more enzymes, there were indications that arginine …
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