Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"MUCOSAL BARRIER"”.
-
Mucosal Barrier Injury, Innate Immunity, and Stem Cell Transplantation
Contains fulltext : 87189.pdf (Publisher’s version ) (Open Access)
-
The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators
… the importance of the damaged epithelial barrier and the dysregulated innate immune system in the pathogenesis of IBD. These two components cause defects in the interaction of the host with the bacterial flora. The epithelium must maintain a physical barrier between the lumen and the …
-
Bacterial Mucolysis, Inflammatory Mucogenesis and the Stability of Host-Intestinal Microbiota Interactions
… ecology and the host. Moreover, the intestinal mucosal barrier serves as an important and necessary mediator of host-microbe interactions. Due to the exquisite sensitivity of this complex system, disruptions to the microbiota, the mucosal barrier or the host-related cells can result in …
-
Illuminating epithelial-stromal communication using engineered synthetic matrix microenvironments
Mucosal barrier tissues are prominent targets for drugs against infection and chronic inflammatory disorders. One such mucosal barrier tissue, the endometrium, undergoes monthly cyclic remodeling via hormone-mediated growth, immune cell recruitment and proteolytic breakdown. Hormone response …
-
Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
… have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial …
-
THE ROLE OF GUT METABOLITES ON REGULATION OF INTESTINAL IMMUNITY
… and pathogens. Maintaining homeostasis at this mucosal barrier requires stringent regulation of the immune responses, including mechanisms to convey information about environmental conditions. Dietary nutrients can be converted into gut metabolites through either host or microbial enzymatic …
-
Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
… of defence in the ocular tissues includes the mucosal barrier and expression of receptors that recognise pathogen. These mechanisms activate the innate immune response during inflammation, however, in the ‘normal’ eye, immunomodulatory components exist to promote immune privilege. 11beta …
-
Staphylococcus aureus Exoproteins on Nasal Epithelial Barrier in Chronic Rhinosinusitis
… with chronic relapsing infections caused by mucosal biofilms that are predominantly due to Staphylococcus aureus. CRS is a prevalent disease affecting around 10% of the general population in Western societies with significant impact on the socio-economical life. However, the pathophysiology …
-
Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΑΣΙΤΙΑΣ, ΠΡΩΤΕΙΝΙΚΗΣ ΔΥΣΘΡΕΨΙΑΣ, ΚΥΤΤΑΡΟΣΤΑΤΙΚΩΝ ΚΑΙ ΑΝΤΙΒΙΟΤΙΚΩΝ, ΣΤΗΝ ΑΚΕΡΑΙΟΤΗΤΑ ΤΟΥ ΒΛΕΝΝΟΓΟΝΙΟΥ ΕΝΤΕΡΙΚΟΥ ΦΡΑΓΜΟΥ. (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ)
… AND CYTOSTATICS ON THE GASTROINTESTINAL MUCOSAL BARRIER. EACH FACTOR WAS EXAMINED EITHER ALONE OR INCOMBINATION. WE STUDIED THE BACTERIAL TRANSLOCATION FROM THE INTESTINAL LUMEN TO MESENTERIC LYMPH NODES, LIVER, SPLEEN, KIDNEY AND LUNGS, BY CULTURING TISSUES FROM THE ABOVE ORGANS AFTER …
-
Molecular characterisation of selected gastrointestinal microbiota in South African HIV-positive patients during HAART
… composition, attributable to a disturbed mucosal barrier, as well as increased permeability and inflammation caused by HIV, can influence the metabolic (carbohydrate fermentation) and protective functions provided by the microbiota. The effect of HIV on the intestinal microbiota has not …
-
Evaluation of Select Food Additive Exposures in Children with Crohn's Disease
… been shown to cause intestinal inflammation, mucosal barrier alterations, and microbiome dysbiosis in animal models, therefore it has been hypothesized that these additives may be associated with disease activity in children with CD. This project evaluated food additive exposure in children …
-
Clinical and Molecular Analyses of Intestinal Goblet Cell Acidomucins and Cysteine Metabolism
Goblet cells are key contributors to intestinal mucosal barrier function through their role in production of mucins and other important secretory products, which include trefoil factor 3 (TFF3) and resistin like molecule β (RETNLB). Goblet cell mucins show great structural heterogeneity but can be …
-
Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… transmissions) between individuals occurs across mucosal tissues (vaginal, rectal, oral). The goal of this thesis was to assess the virologic and immunologic events following oral inoculation of macaques with Simian Immunodeficiency Virus (SIV) and correlate these findings with disease …
-
The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV infection has not been clearly elucidated. Although mucosal epithelial cells express only low levels of the …
-
The role of bacterial vaginosis-associated sialidase on HIV-1 infection
… the viscosity of the female vaginal tract (FGT) mucosal barrier, increasing the likelihood of infection. This study aimed to determine the impact of bacterial sialidase on HIV-1 infection focussing specifically on the BVAB, G. vaginalis. Pseudovirus was produced by transfection of HEK293T cells …
-
Synergism between immune activators and progestogens: differential effects on gene expression and HIV-1 replication and the role of the glucocorticoid receptor
… that MPA and LNG impairs the integrity of mucosal barrier of the FGT. This study investigated the central hypothesis that MPA, NET and LNG acting alone or in synergy with immune activators [tumour necrosis factor-alpha (TNF) and lipopolysaccharide (LPS)] via the glucocorticoid receptor (GR) …
-
Screening of radioprotective agents using zebrafish and Therapeutic effects and protective mechanism of radioprotective candidates on radiation-induced oral mucositis
… general oral hygiene, and the use of various mucosal barrier agents and radioprotective agents, such as amifostine. Despite the clinical significance of oral mucositis, there is no definite approved treatment In this study, we have used the in vivo zebrafish model to screen for radioprotective …
-
Nod1 and Nod2 in Innate Immune Responses, Adaptive Immunity and Bacterial Infection
… seen in Nod1-deficient mice localizes to the mucosal barrier where these dendritic cells appear to have an impaired response towards the bacteria. Taken together, these results increase our knowledge on the general role of Nod1 and Nod2 in immunity and might generate new avenues of research …
-
Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
… deformation may contribute to recovery from mucosal injury and restoration of the mucosal barrier in patients with prolonged ileus. ILK may therefore be an important target for intervention to maintain the mucosa in such patients.</p>
-
The relationship between S. aureus biofilm properties, inflammation, and disease severity in chronic rhinosinusitis
… inflammatory clusters. Staphylococcus aureus mucosal biofilms are associated with severe recalcitrant CRS. However, S. aureus colonisation of the nose and paranasal sinus mucosa is also frequent in the absence of mucosal inflammation. This questions the relevance of S. aureus biofilms in CRS …
Page 1 of 2