Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"MUC1"”.
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Rekombinante Antikörper gegen tumorassoziiertes MUC1
… Mammakarzinom wird das tumorassoziierte Antigen MUC1 überexprimiert, dessen extrazelluläre Domäne zum größten Teil aus einem als VNTR (variable number of tandem repeats)-Region bezeichneten Abschnitt besteht. Aufgrund einer im Vergleich zu normalem MUC1 veränderten, weniger starken Glykosylierung …
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In silico redesign and de novo design of anti-MUC1 monoclonal antibodies
Mucin 1 (MUC1) is a cellular membrane-tethered protein which is abnormally glycosylated and overexpressed in several epithelial cancers. This abnormal glycosylation is hypothesized to participate in the hyper-activation of signaling pathways which promote tumor growth and provides a suitable target …
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New insights into molecular recognition of epitopes related to MUC1 human mucin by lectins
… glycopeptides and glycoproteins, in particular MUC1, incorporate this structure in their sequence. While in normal cells this O-glycosylated protein carries complex oligosaccharides, in cancer cells, MUC1 expression is increased and its glycans are short and poorly branched. Therefore, Tn …
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Investigating breast cancer O-linked glycosylation changes and their immunotherapeutic potential
… and mainly belong to the MUC family, with MUC1 considered one of its most prestigious affiliates, as it is<br/>upregulated and aberrantly glycosylated in the majority of breast and many other<br/>adenocarcinomas. The large domain of the extracellular region of MUC1 is made up of tandemly …
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Design of Therapeutic Vaccines Based on the Tn Antigen
… en glicopéptidos no naturales derivados de MUC1 que incorporan el antígeno Tn en posiciones estratégicas de la secuencia peptídica. Aunque estos glicopéptidos presentan un alto potencial como vacunas contra el cáncer, las formulaciones basadas en MUC1 suelen inducir respuestas inmunitarias …
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Separation and purification of mucins and tenascin-C in breast milk of patients and the investigation of the role of mucins and tenascin-C in the inhibition of HIV-1
… properties. Previously in our laboratory, MUC1 and MUC4 has been implicated in the inhibition of HIV-1 in an in vitro assay. Furthermore, crude breast milk was tested in this assay showing strong HIV-1 neutralisation. Pasteurisation (80°C for 10 minutes) of both HIV positive and negative …
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Structure-guided Cancer Vaccines based on Glycopeptides Supported on Diverse Nanoparticles
… this thesis, we focus on the peptide sequence of MUC1, a glycoprotein presents on the surface of epithelial cells, which leaves simple carbohydrates, and the backbone of the peptide exposed in cancer cells due to aberrant glycosylation. In nature, this exposure to the immune system doesn't trigger …
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Structure-based design of unnatural glycopeptides for cancer diagnosis and therapy
… han desarrollado glicopéptidos no naturales de MUC1 utilizando un diseño racional basado en estructura. Este trabajo se ha apoyado en datos previamente reportados con el fin de mejorar la afinidad de estos derivados in vitro con anticuerpos bien estudiados, incorporando sustitutos sintéticos de …
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SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES
… the presence of the anti-Rha antibodies.</p><p> MUC1 variable number tandem repeats (VNTRs) conjugated to tumor-associated carbohydrate antigens (TACAs) have been shown to break self-tolerance in humanized MUC1 transgenic mice. Therefore, we hypothesize that a MUC1 VNTR TACA-conjugate can be …
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Unnatural glycopeptides with application on cancer research
… fight against cancer: mucins, such as mucin-1 (MUC1), and antifreeze glycoproteins. Concerning the first mentioned class, mucins are a family of O-glycoproteins with high molecular weight that serve as cell-surface receptors and sensors. Notably, aberration in the glycosylation of this tandem …
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A two-pronged approach towards the development of novel therapeutics for advanced endometrial cancer
… mechanism and physiological effect of mucin 1 (MUC1)-driven epidermal growth factor receptor (EGFR) expression and signaling. MUC1 is a large, heavily glycosylated transmembrane protein that functions to lubricate surfaces, provides protection from external insult and plays an important role in …
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Structure-based design of glycopeptides featuring unnatural tn antigens and their applications to cancer vaccination and diagnosis
… incluido en el esqueleto peptídico de la mucina MUC1. Conocer la estructura de este tipo de glicoproteínas es clave para poder mejorar su interacción con moléculas de interés biológico, tales como lectinas, enzimas o, el caso que nos ocupa, anticuerpos. El antígeno Tn se define comúnmente como …
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
… to the silencing of the metastasis gene mucin 1 (MUC1). Using luciferase reporters carrying the 3′-untranslated region of MUC1 combined with Western blot and immunofluorescence staining, we identify MUC1 as a direct target of miR-145. Moreover, ectopic expression of MUC1 enhances cell invasion, …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… between influenza virus and tethered mucin 1 (MUC1), finding that MUC1 expression is enhanced by virus-driven inflammation and interferon signaling. Moreover, by establishing a genetically-tractable airway epithelial model, we detail the protective role MUC1 plays in preventing the initial …
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Functional DNA Aptamers as Biotherapeutic Molecules
… As well, I investigated the use of CEA and MUC1 binding aptamers as targeting agents to guide and detect the delivery of contrast agent-loaded liposomes in tumour-bearing mice using computed tomography (CT) imaging. Aptamer selections successfully identified a 25-base aptamer (VR11) that can …
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Reconocimiento Molecular de Análogos de Antígenos Tn como Base para el Diseño de Vacunas Terapéuticas contra el Cáncer
… en los patrones de glicosilación de la MUC1, lo cual va asociado a la exposición de determinados antígenos que se encuentran enmascarados en las moléculas presentes en las células sanas. Esta característica abre la posibilidad de su utilización como diana terapéutica ya que, mediante su …
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Development of coupled enzyme assay and in vitro synthetic biology approach for glycosylation pathway characterization
… the correlation of aberrant glycosylation of MUC1 that is associated with certain cancers. Central to this is an accurate MUC1 peptide monomer and associated glycosyltransferases (GTs) able to be deployed in specific construction. However, deconstructing the machinery of the GTsubstrate …
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Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.
… phenotypes: capsular stem cells were EMA (MUC1)+, MDM2+, Vimentin+ and Wnt1+; progenitors of the sub-capsular nephrogenic zone were MDM2+ and Wnt1+; cap mesenchymal cells were EMA (MUC1)+, CD15+, vimentin+, Wt1+, CD10+, Bcl2+, Wnt1+ and PAX2+; interstitial progenitor cells were Vimentin+, …
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A study of morphological, immunohistochemical and histochemical features of ampullary carcinomas
… a literature review and included p53, Ki-67, MUC1, MUC1core, MUC2 and CA 19.9. The data was analyzed by multivariate analysis.
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Protein L Functionalized Microparticles For Early Detection of Surface Markers In Heterogeneous Colorectal Lesions
… L functionalized MPs identify Mucin 1 (MUC1) and epithelial cell adhesion molecule EpCAM positive tumoroids proportionally to antigen expression, 2) Antibody-Protein L MPs detect CRC surface antigens on the luminal colon surface in vivo, and 3) concurrent targeting of multiple surface …
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