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Showing 1 to 20 of 46 for “"MTX"”.
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Development of a HPLC method for the determination of methotrexate (MTX) and MTX-polyglutamates of red blood cells: A dissertation submitted in partial fulfilment of the requirements for the Degree of Bachelor of Science with Honours at Lincoln University
Methotrexate (MTX) low-dose therapy has been increasingly used for the treatment of patients with rheumatoid arthritis (RA). Patient response to, the drug and development of side effects are poorly understood. There is large a variation in clinical response between patients and this influences the …
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Comparative Effectiveness of Methotrexate-Based Disease-Modifying Antirheumatic Drug Combinations for Rheumatoid Arthritis
… arthritis (RA) initiating methotrexate (MTX); [2] to compare the effectiveness of MTX-based disease-modifying antirheumatic drugs (DMARDs) combinations, including csDMARDs plus MTX, TNFi plus MTX, non-TNFi biologics plus MTX or tsDMARDs plus MTX in RA; [3] to examine the risk of …
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Investigation of anthracycline based topoisomerase II inhibitors in triple negative breast cancer
… on chemotherapy for treatment. Mitoxantrone (MTX), a topoisomerase II inhibitor belonging to the anthracenedione class, is used in BCa therapy. This thesis investigates the potential and mechanism of action of the MTX analogue KP71 and two metal organic frameworks (MOFs), UiO-66 and …
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Synthesis and pharmacological evaluation of novel anti-tumour prodrugs. Synthesis and pharmacological investigations into novel MMP-activated peptide-based prodrugs of methotrexate as potential cancer therapeutics
Methotrexate (MTX) is an antimetabolite anticancer agent that is used in treatment of multiple cancers, such as acute lymphoblastic leukaemia and osteosarcoma. A lack of selective tumour toxicity is one of the major problems associated with MTX chemotherapy, especially when given at high doses, as …
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Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System
… loading, release and activity of mitoxantrone (MTX), we synthesized thiol (SH), mixed thiol/amine (SH/NH2) and amine (NH2) functionalized MSN by sol-gel process. We observed that NH2</p> <p>modification of MSN has limited MTX loading. In contrast, modifications of MSN with SH resulted in …
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The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury
… with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial …
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Effect of diet on methotrexate toxicity
… toxicity induced by methotrexate (MTX) in rats. Toxicity was determined by severity of anorexia and incidence of diarrhea on d 3 and 4 following an intraperitoneal injection of 20 mg MTX per kg body weight. Rats adapted to a casein-based semipurified diet for 14 d developed severe …
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Entwicklung von tumorhemmenden Polymer-Wirkstoff-Konjugaten des Zytostatikums Methotrexat auf der Basis von linearem Polyethylenglykol
… bestehend aus dem Zytostatikum Methotrexat (MTX) und linearem Polyethylenglykol (PEG) zu synthetiseren und auf ihre tumorhemmenden Eigenschaften hin zu untersuchen. Aus diesen Ergebnissen sollten Struktur-Wirkungs-Beziehungen für diese Art von Substanzen herausgearbeitet werden. Im ersten …
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Methotrexat-induzierte Leukenzephalopathie bei Patienten mit akuter lymphatischer Leukämie oder lymphoblastischem Non-Hodgkin-Lymphom in Abhängigkeit vom MTHFR-C677T-Status
… of folate metabolism, so that combination of MTX-therapy and mutation of the MTHFR gene (MTHFR C677T) might result in altered toxicity. We examined 31 children with ALL or NHL, that were treated according to GPOH ALL-BFM 95 or 98 protokoll at the pediatric department of Aachen University …
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Protein Dynamics and its Correlation to Protein Activity and Stability
… inferred by neutron spectroscopy, the binding of MTX influences the dynamical behavior of DHFR. Macromolecular dynamics such as the resilience: lt;kgt; (i.e. structural rigidity) was found to be increased and, inversely, the flexibility decreased upon MTX binding. In addition, as revealed by …
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Emergenza clonale di resistenza al metotrexato nelle cellule PDX con codice a barre dell'osteosarcoma
… nei meccanismi di resistenza al metotrexato (MTX) nelle cellule di osteosarcoma. Al fine di chiarire l'emergenza clonale della resistenza alla chemioterapia mirata e citotossica nell'osteosarcoma, abbiamo quindi lavorato sul codice a barre delle nostre linee cellulari derivate da modelli di …
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Can curcumin improve the methotrexate based treatment for rheumatoid arthritis?
… due to the side effects involved. Methotrexate (MTX) is currently used as first line treatment due to its ability to modify the rheumatic conditions so that disease progression can be prevented. However, at the same time prolonged exposure to MTX can lead to severe side effects such as lung …
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Molecular and Functional Analyses of Transport Proteins for Organic Anions
… the Mrp2-substrate fluorescein-methotrexate (FL-MTX), transport is not regulated by proteinkinase (PK) A, and PKC. For better characterization of kinetic parameters I studied transport of fluo-cAMP in membrane vesicles of MRP2 and MRP4 overexpressing cells. Both MRPs transported fluo-cAMP with …
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Effect of Scutellaria Baicalensis on Reduction of Radiation/chemotherapy induced Inflammation
… and in vivo using Wistar rat with methotrexate (MTX) induced enteritis or radiation induced proctitis. In vivo study, we used 6-8 week-old female Wistar rat. Rats for MTX induced enteritis were orally administrated once a day with three different concentrations (5, 10, and 15 mg/kg) of S and …
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Pharmacogenetic markers of response to drugs used in the management of Inflammatory Bowel Disease
… Bowel Disease (IBD) treated with methotrexate (MTX). The HLA-G 14 bp ins/del polymorphism was correlated with azathioprine (AZA) response in 97 IBD patients. The IL-10 -1082A>G, -819C>T and -592C>A promoter SNPs on chromosome 1 were examined for an influence on the effect of the 14bp ins/del …
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Amplification of the DFR1 gene in Saccaromyces cerevisiae
… in each strain . Yeast cells were se l ected for MTX-resistance and overproduction of ~ galac t osi d se ( B-gal ). Since the inserted DF'Rl and ~ACZ genes are independently regulated, it was thought that cel l s with this phenotype probably contain e d ampl if ications of the cassette. A lar ge …
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Using Advanced In Vitro Models to Investigate the Adverse Effects of Methotrexate on the Developing Epigenome
… epigenome. The folate antagonist methotrexate (MTX) was used at lower doses, equivalent to doses for treatment of rheumatoid arthritis, to interrogate the impact of perinatal exposure on the developing epigenome in vitro. Treatment of mouse embryonic stem cells (mESC) and epiblast-like cells …
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Development of in vitro infant intestinal models to assess responses to infant formulae
… than the conventional adult-like Caco-2/HT29-MTX co-culture. In chapter 2, Caco-2/HT29-MTX polarized monolayers were treated with the short-chain fatty acid salt sodium butyrate (NaB), previously reported to increase permeability without harm. High NaB concentrations (50–125 mM) reduced …
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Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane
… encapsulating the anticancer drug methotrexate (MTX) were applied to HeLa cells and demonstrated much higher cytotoxicity than the free drug and negative controls, indicating that they could conduct more efficient cellular delivery of MTX. The MTX-loaded fliposomes inhibited tumor growth in …
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"Clostridium botulinum" C2-Toxin: Interaktion der Toxinkomponenten und Translokation der Enzymkomponente in das Zytosol von Zielzellen
… Fusionstoxin war biologisch aktiv. Methotrexat (MTX), ein Substratanalogon der Dihydrofolatreduktase, interagierte spezifisch mit der DHFR-Domäne des Moleküls. Es schützte das Fusionstoxin vor dem Abbau durch Trypsin und stabilisierte die Struktur des Fusionstoxins. MTX verzögerte die Vergiftung …
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