Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"MTD"”.
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Modified 3+3 Design for MTD Re-estimation
… trials to identify the maximum tolerated dose (MTD) for new treatment regimens. While this design is widely used due to its simplicity , it has some notable limitations, including a maximum of six patients per dose level and fixed target toxicity rates. To address these issues, we propose a …
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Establishing a standard scientific guideline for the evaluation and adoption of multi-tenant database
A Multi-tenant database (MTD) is a way of deploying a Database as a Service (DaaS). A multi-tenant database refers to a principle where a single instance of a Database Management System (DBMS) runs on a server, serving multiple clients organisations (tenants). This technology has helped to discard …
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Pathogen-induced protein secretion in plants.
… by making the enzyme mannitol dehydrogenase (MTD) to catabolize fungal mannitol. Here we show that the normally cytoplasmic enzyme MTD is exported into the extracellular space in response to the endogenous inducer of plant defense responses salicylic acid (SA). This SA-induced secretion is …
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An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
… is to determine the maximum tolerated dose (MTD). The MTD is defined as the dose level below the dose at which two of six patients experience drug-related dose-limiting toxicity (DLT). In phase I trials that combine two agents, more than one MTD generally exists, although all are rarely …
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Dual-Criterion Dose Finding Designs for Phase I Clinical Trials
… methods identify the maximum tolerated dose (MTD) based on dose-limiting toxicity (DLT). However, as cancer therapies have evolved from chemotherapy to targeted therapies, these traditional methods have become problematic. Many targeted therapies rarely produce DLT and are administered over …
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The Effects of Metronomic and Maximum-Tolerated Dose Chemotherapy in Colorectal Cancer Angiogenesis: A Combined Approach Using Endoscopic Diffuse Reflectance Spectroscopy and mRNA Expression
… with the use of mainstay maximtolerated dose (MTD) chemotherapeutic strategies. Metronomic chemotherapy (MET) has been developed as an alternative that addresses the shortcomings of maximum-tolerated dose chemotherapy but so far its effectiveness as a neoadjuvant strategy for CRC has not been …
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Evaluating exposure to and perceptions of the Woolworths Healthy Tuck Shop Guide in Cape Town, South Africa
… of them is the Woolworths Making the Difference (MTD) Programme aimed at eliminating barriers to promoting healthy lifestyles that exist at schools, such as the availability of low cost, unhealthy foods either from tuck shops or street vendors. The Healthy Tuck Shop Guide is a recent addition to …
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An inventory planning methodology for a semiconductor manufacturer with significant sources of variability
… methodology is demonstrated for one important MTD product, the methodology can potentially be used for other MTD products with similar regular demand patterns. While holding inventory provides short-term solutions to problems such as cycle time variability, the framework provides a means for …
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Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303
… i.v. route (dosed at the maximum tolerated dose (MTD)) showed that SJG-136 reaches concentrations in plasma well in excess of the in vitro IC50 values for 1 h exposure, and was detected in tumour and brain samples also above the in vitro IC50 values. Furthermore, SJG-136 showed linear …
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Refactorización e implementación de pruebas unitarias en el motor de Transacciones Digitales de Instance
… esto que el Motor de Transacciones Digitales (MTD), fue construido de manera muy rápida y respondiendo a requerimientos sin tomar en cuenta mantenibilidad, escalabilidad y eficiencia para poder obtener lo antes posible una plataforma funcional. Y si bien la plataforma funciona y soluciona el …
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RESONANT: Reinforcement Learning Based Moving Target Defense for Detecting Credit Card Fraud
… proposes an adaptive moving target defense (MTD) approach based on deep reinforcement learning (DRL), termed RESONANT to identify the optimal switching points to another ML classifier for credit card fraud detection. It identifies optimal moments to strategically switch between different …
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Comparison of Macrotexture Measuring Devices Used in Virginia
… the volumetric (Sand Patch) mean texture depth (MTD). Furthermore, texture convexity had a significant effect on the correlation between the measurements obtained with different devices. Two sets of models for converting the laser-based texture measurements to an estimated MTD (ETD) were …
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Neuroblastoma: A Theoretical Dose Dependent Study With Therapeutic Implications
… due to the spectrum of disease staging, with MTD not necessary for many patients. Herein I propose several theoretical experiments that I believe will elucidate potential therapeutic treatment options. New dosages and combinations of drugs may be the key in preventing the relapse of NB.</p>
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Bayesian Designs For Early Phase Clinical Trials With Novel Target Agents
… proposed to find the maximum tolerated dose (MTD) in phase I clinical trials, but their differences and relative pros and cons are not clear to many practitioners. We review three model-based designs, including the continual reassessment method (CRM), dose escalation with overdose control …
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Analysis of the microarchitecutre of the human femoral head using micro-computertomography
… were aligned along the main trabecular direction(MTD). The upper hemisphere of each femoral head was included in the analysis. Femoral neck area was designated as 12 o'clock and 12 identical 30-degree arcs around a same center were assigned in each image. Each volume of interest was sub-divided …
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Bayesian Semi-Mechanistic Dose-Finding Designs For Phase I Oncology Trials
… identification of the maximum tolerated dose (MTD) in a phase I trial is crucial for identifying a tolerable and efficacious dose through subsequent confirmatory trials. Since pharmacokinetics/pharmacodynamics (PK/PD) information reflects partially drug exposure and drug-receptor interactions, …
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Advancing sepsis treatment: synthesis and evaluation of multi-target drugs with antimicrobial, antioxidant and anticoagulant properties.
… aims to develop a series of multi-target drugs (MTDs) to address the various pathologies of sepsis, specifically targeting infection, OS, and abnormal blood coagulation. A total of 11 MTD (JW1-JW11) compounds were synthesised, incorporating Naphthalimido and phenolic groups, with yields ranging …
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Hypoglycemia In Mitochondrial Disorders
… of the ETC lead to mitochondrial disorders (MTDs). MTDs are multi-system conditions affecting the heart, muscles, and especially brain. The endocrine system is commonly affected in MTDs, and diabetes and hyperglycemia are established secondary diagnoses. Rates of non-iatrogenic hypoglycemia …
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Efeito do Treinamento Físico Moderado sobre Linfócitos do Sangue e Baço de Ratos Adultos Submetidos à Desnutrição Perinatal
… maiores taxas de despolarização mitocondrial (MTD) e externalização de fosfatidilserina (PSE) que ratos controle (MTD: LP+LPS = 18,0±1,9% vs C+LPS = 6,1±1,9%, p<0,001; PSE: LP+LPS = 51,0±3,7% vs C+LPS = 26,5±2,8%, p<0,001). Entretanto, ratos LP+T+LPS apresentaram menor taxa de apoptose que …
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