Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"MTAP"”.
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Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
… of the methylthioadenosine phosphorylase (MTAP) gene, which occurs in 50% of all GBM cases. Despite its common occurrence, it is unclear what contribution MTAP loss makes in the pathogenesis of GBM or whether this genetic alteration can be used as a therapeutic target. </p><p>MTAP is a …
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Treating MTAP-Deficient Brain Tumors with Purine Synthesis Inhibition
… cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via treatment with L-Alanosine (ALA), an …
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Therapeutic Potential of Prmt5 and Mat2A As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors
… of methylthioadenosine phosphorylase (<em>MTAP</em>) is a frequent genetic alteration found in approximately 15% of all human cancers, including glioblastoma, pancreatic cancer, mesothelioma, urothelial bladder carcinoma, and lung squamous cell carcinoma. MTAP is a critical metabolic enzyme …
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Effect of Antibiotic Pastes on Chemical Structure and Microhardness of Radicular Dentin
… minocycline. A modified triple antibiotic paste (MTAP) that replaces minocycline with clindamycin has recently been suggested to avoid the tooth discoloration and potential demineralization from minocycline. The effect these pastes have on radicular dentin is unknown. Objectives: The aim of this …
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Rational drug combinations to selectively target 9p21-deleted bladder cancer
… being tested in clinical trials to treat MTAP-deleted tumors. Here, we performed a multi-parametric drug screening using 9p21 isogenic BLCA cells to uncover drugs with a 9p21-selective activity on cell morphology and viability. Two drugs resulted significantly more effective in cells with …
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An Evaluation of the Effectiveness of Montana’s HIV Prevention Groups for Men Who Have Sex With Men
… of MSM recruited by Montana Targeted Prevention (MTaP) workers during the course of their regular HIV/Hepatitis C outreach activities. Behavioral changes in unprotected anal intercourse and substance use and seven HIV-transmission-behavior influencing factors (sexual communication skills, …
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An Evaluation of the Effectiveness of Montana’s HIV Prevention Groups for Men Who Have Sex With Men
… of MSM recruited by Montana Targeted Prevention (MTaP) workers during the course of their regular HIV/Hepatitis C outreach activities. Behavioral changes in unprotected anal intercourse and substance use and seven HIV-transmission-behavior influencing factors (sexual communication skills, …
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Study of genetic by environmental interactions at transcriptomic and genomic levels
… TOPORS, HRAS, MDM2, CAMK2G, FSTL1, IL13RA1, MTAP and TP53. Of the genes associated with GBM on a cohort-manner, C2, EGFR, PRKCB, IGF2BP3, and GDF10 had gender-dependent associations; SOX10, RPS20, RAB31, and VAV3 had race-dependent associations; CHI3L1, PRKCB, POLR2D, and APOOL had …
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Pricing and eminent domain takings: A case study of residential property in Las Vegas, Nevada
This case study tests whether compensation for eminent domain takings equals estimated market prices for residential property located near McCarran Airport in Clark County Nevada. The hedonic model provides evidence that takings compensation was often less than estimated market price, a discount …