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Showing 1 to 17 of 17 for “"MT1-MMP"”.
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MT1-MMP enhances cell survival and proliferation via roles unrelated to metabolic transcript levels in MCF7 breast cancer cells
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a multifunctional protease implicated in cancer aggressiveness for its ability to promote proliferation, migration, and invasion, particularly at low expression levels. Due to its multidomain structure and cell signalling abilities, MT1-MMP may …
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The Cytoplasmic Domain of Membrane-type 1 Matrix Metalloproteinase is Required for its Survival-Promoting, but not its Migration-Promoting Function in MCF-7 Breast Cancer Cells
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a multifunctional protease that degrades proteins during cell migration, and influences cell survival. Both the protein localization and signal transduction capabilities of MT1-MMP depend on its cytoplasmic domain (CD), indicative of a diverse …
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Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex
… as an inhibitor of matrix metalloproteinases (MMPs) and therefore as a molecule that prevents ECM degradation and proteolytic cleavage of extra-cellular molecules, processes thought to be critical for tumor invasion and metastasis. However, TIMP-1 has shown in the clinic to have increased …
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Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
Membrane type-1 matrix metalloproteinase (MT1-MMP) is a metalloproteinase which becomes upregulated in prostate cancer and has been implicated in processes of prostate cancer metastasis. Here, we show that MT1-MMP is minimally expressed in nonmalignant primary prostate cells, moderately expressed …
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Optimization of fluorescence lifetime imaging microscopy (FLIM) for studying the activity of enzymes in live cancer cells
… is Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) which is a membrane-bound protein principally responsible for degrading extra-cellular matrix (ECM) proteins in the local environment of a migrating cell. However, MT1-MMP has an intricate role in the regulation of the cell’s migration …
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
<p>Matrix metalloproteinases (MMPs) have been postulated to be important for angiogenesis and for tissue remodeling events associated with corpus luteum (CL) development. The MMPs are mainly regulated at three levels, transcription, activation, and inhibition by endogenous tissue inhibitors of …
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Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases capable of digesting the extracellular matrix (ECM), which is essential for tissue structure and transmitting messages between cells. MMPs play an important role in cancer, controlling cell migration, proliferation, apoptosis, …
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Die Expression und Lokalisation von Matrix Metalloproteinasen (MMP) und ihrer spezifischen endogenen Inhibitoren (TIMP) in menschlichen primären Gehirntumoren
… und Aktivierung von Matrix Metalloproteinasen (MMP) und ihrer spezifischen Inhibitoren (TIMP) in primären menschlichen Gehirntumoren zu beschreiben, und die Proteine im Gewebe zu lokalisieren. Ausganshypothese war, dass es bei der malignen Progression von Gliomen zu einer Zunahme der …
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Mathematical Modelling of Cancer Growth and Spread: The Role of Matrix Metalloproteinases
… the proteolytic activity of the membrane bound MT1-MMP protein and the soluble MMP-2 protein in addition to the complexes formed, and consequences thereof, from interactions they have with one another and their endogenous inhibitor TIMP-2. In Chapter 5 we develop the PDE model of cancer cell …
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Regulation of Matrix Metalloproteinases and Their Inhibitors by DNA Methylation in Human Gestational Tissues
… therapeutic avenues. Matrix metalloproteinases (MMPs) and specific endogenous tissue inhibitors of metalloproteinases (TIMPs) are key mediators of fetal membrane rupture during physiological and pathological labour. Membrane type MMPs (MT-MMPs) activate secreted MMPs in addition to degrading the …
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Μελέτη της έκφρασης και του ρόλου της σεργλυκίνης στις κακοήθειες
… του εξωκυττάριου χώρου, όπως οι tPA, uPA, MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP και του αναστολέα των μεταλλοπρωτεϊνασών TIMP-1. Παρουσιάσθηκε ότι η υπερέκφραση του πλήρους μορίου της SG αλλά και της μη γλυκοζυλιωμένης της μορφής οδηγούν στη διαφοροποίηση της έκφρασης και της ενεργότητας των …
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Efeito da sinvastatina na modulação da expressão de Reck e suas isoformas em células de melanoma humano
… pela acao das metaloproteinases de matriz (MMPs), que degradam a matriz extracelular, favorecendo a invasao. Entre os elementos que podem regular a atividade de MMPs esta RECK, uma glicoproteina ancorada a membrana celular. Tendo em vista que as estatinas sao drogas que inibem a sintese de …
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Transient collagen triple-helix binding to membrane type 1 matrix metalloproteinase : interaction studies and NMR-guided structural docking
… THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] MT1-MMP (MMP-14) as pericellular collagenase is critically involved in cancer cell invasion through collagen barriers that it degrades. To better understand the structural and mechanistic details underlying collagenolytic activity of MMP-14, a …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… expression of the matrix metalloproteases (MMPs) MT1-MMP and MMP-2. We also demonstrate that SPARC increases MMP-2 activation and the secretion and processing of galectin-3, a known target of MMPs. To investigate the roles of specific domains, we used a SPARC-GFP fusion protein and deletion …
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Implication des protéines adaptatrices Tks4 et Tks5 dans la dégradation du cartilage articulaire par les synoviocytes dans la polyarthrite rhumatoïde
… et qu’il y a formation d’un complexe entre la MT1-MMP et Tks4 et/ou Tks5. Finalement, nous avons démontré que l’inhibition de la Tks4 chez des rats CIA permettait de diminuer significativement le nombre et l’ampleur des zones de dégradations du cartilage par les cellules composant la membrane …