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Showing 1 to 6 of 6 for “"MSU crystals"”.
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Designing Peptide-Based Biosensors for the Diagnosis of Crystal Arthropathies
… of peptides to the surfaces of monosodium urate (MSU) crystals. MSU crystals accumulate in the joints of patients with acute gout, one of several types of crystal arthropathy. Other arthritides, including pseudo-gout and osteoarthritis, present similar symptoms to gout, but are characterised by …
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Gout Biosensor: Towards the development of a peptide-based diagnostic for crystal arthropathies and Amplifying Graduate Student Perspectives on Supervision and Satisfaction at the University of Calgary
… methods to distinguish between monosodium urate (MSU) crystals, which cause gout, and calcium pyrophosphate dihydrate (CPPD) crystals, responsible for pseudogout. The current gold-standard diagnostic approach, compensated polarized light microscopy, is limited by its dependence on operator skill …
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Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout
… phagocytosis of monosodium urate monohydrate (MSU) crystals by monocytes/macrophages resulting in downstream expression and production of interleukin-1 beta (IL-1β) and chemokines. The activation of monocytes by MSU crystals involves the priming of monocytes with danger signals e.g. …
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Cluster Determinant 44 (CD44) Receptor and Gout: Mechanistic Role in Pathogenesis and Therapeutic Targets
… is caused by deposition of monosodium urate (MSU) crystals in peripheral joints and surrounding tissues, which activate the resident macrophages to produce pro-inflammatory cytokines and consequently leads to an inflammatory response. The CD44 receptor is highly expressed in macrophages and …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… chronic arthritis caused by monosodium urate (MSU) crystal deposition in joints leading to activation of synovial resident macrophages and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) and reactive oxygen species (ROS) that activate …
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Investigating the Contribution of the Inflammasome to Persistent Pain States
… (ATP), monosodium urate (MSU) crystals).<br/>Data presented in this thesis demonstrates that, following L5 Spinal Nerve Transection (SNT), an animal model of neuropathic pain, inflammasome components NLRP3, ASC, and caspase-1 are upregulated in the injured DRG and the …