Global ETD Search
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Showing 1 to 2 of 2 for “"MSI1"”.
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Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… specific RNA binding protein, Mushashi-1 (MSI1). I hypothesize that this feedback loop serves to maintain a critical balance and that disruption of this balance leads to loss of homeostasis and ultimately tumorigenesis in the intestinal epithelium. Studies described here and by others have …
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Investigating the importance of the Zika virus 3′ untranslated region to viral fitness
The RNA binding protein Musashi 1 (MSI1) has been shown to bind to the Zika virus (ZIKV) 3′ untranslated region (3′UTR) and enhance viral replication. MSI1 is present in high levels in neural progenitor cells of the foetal brain, and previous work proposed that MSI1 could drive the pathogenesis …