Global ETD Search
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Showing 1 to 5 of 5 for “"MSH4"”.
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Design, Synthesis, And Testing Of Multivalent Compounds Targeted To Melanocortin Receptors
… stimulating hormone, His-DPhe-Arg-Trp-NH₂ (MSH4), which binds with low micromolar affinity to α-melanocyte stimulating hormone receptors, were synthesized. Binding affinities of these constructs were evaluated in a competitive binding assay by competing with labeled ligands, …
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The Role of Arabidopsis thaliana Mismatch Repair Proteins in Meiotic Recombination
… the genome-wide distribution of MutS homolog 4 (MSH4). MSH4, and its binding partner MutS homolog 5, evolved from their ancestral role in MMR and now function exclusively to promote meiotic crossovers in the ZMM pathway. I present a genome-wide chromatin-immunoprecipitation-sequencing analysis of …
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Identificación y validación funcional de la mutación c.2355+1G>A en MSH4 descubierta en una familia afectada por insuficiencia ovárica primaria: descripción de una nueva etiología molecular de la enfermedad
… del sitio de splicing en el gen de meiosis MSH4. Se determinó que esta mutación es causal del fenotipo y por primera vez se asoció una versión mutante de MSH4 con el fenotipo de IOP.
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Identificación y validación funcional de nuevos genes y mutaciones asociadas a la etiología de la insuficiencia ovárica primaria (IOP) : implicación de los genes BMP15, BMPR2, MSH4, ATG7, ATG9A y NOTCH2
… en los genes: BMPR2 (c.2960C>T-p.Ser987Phe), MSH4 (c.2355+1G>A-p.Ile743_Arg785del), ATG7 (c.1209T>A-p.Phe403Leu), ATG9A (c.2272C>T-p.Arg758Cys) y NOTCH2 (c.5411C>T-p.Ser1804L, c.6947>T-p.Ala2316Val y c.7075C>G-p.Pro2359A) modifican la función cada una de las proteínas WT (wild type). …
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Epic Search for the Perfect Partner: MutSgamma Promotes Efficient Meiotic Recombination and Homolog Pairing in Mouse Spermatocytes
… budding yeast, MutSgamma, a heterodimer between MSH4 and MSH5, promotes crossover-specific recombination by protecting precursors and, in many organisms, plays roles in pairing and synaptonemal complex formation. In mice, it has been shown that MutSgamma is required for crossover formation. These …